Gene/Proteome Database (LMPD)

LMPD ID
LMP002367
Gene ID
51763
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate-5-phosphatase K
Gene Symbol
INPP5K
Synonyms
PPS; SKIP
Chromosome
17
Map Location
17p13.3
EC Number
3.1.3.56
Summary
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Orthologs
View orthologs and multiple alignments for INPP5K

Proteins

inositol polyphosphate 5-phosphatase K isoform 1
Refseq ID NP_057616
Protein GI 18765709
UniProt ID Q9BT40
mRNA ID NM_016532
Length 448
RefSeq Status REVIEWED
MSSRKLSGPKGRRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELNSGIISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGISRPFQIPPGSLREDPLGEAQPQI
inositol polyphosphate 5-phosphatase K isoform 2
Refseq ID NP_570122
Protein GI 18765707
UniProt ID Q9BT40
mRNA ID NM_130766
Length 372
RefSeq Status REVIEWED
MDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGISRPFQIPPGSLREDPLGEAQPQI
inositol polyphosphate 5-phosphatase K isoform 2
Refseq ID NP_001129114
Protein GI 208610044
UniProt ID Q9BT40
mRNA ID NM_001135642
Length 372
RefSeq Status REVIEWED
Protein sequence is identical to GI:18765707 (mRNA isoform)

Gene Information

Entrez Gene ID
51763
Gene Name
inositol polyphosphate-5-phosphatase K
Gene Symbol
INPP5K
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0016020 IDA:UniProtKB C membrane
GO:0043005 IDA:UniProtKB C neuron projection
GO:0005634 IDA:UniProtKB C nucleus
GO:0048471 IDA:UniProtKB C perinuclear region of cytoplasm
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0001726 IDA:MGI C ruffle
GO:0032587 IDA:UniProtKB C ruffle membrane
GO:0005802 IDA:UniProtKB C trans-Golgi network
GO:0016312 IDA:MGI F inositol bisphosphate phosphatase activity
GO:0046030 IDA:MGI F inositol trisphosphate phosphatase activity
GO:0052659 IEA:UniProtKB-EC F inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052658 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445 IEA:UniProtKB-EC F inositol-polyphosphate 5-phosphatase activity
GO:0042577 NAS:UniProtKB F lipid phosphatase activity
GO:0034595 IMP:UniProtKB F phosphatidylinositol phosphate 5-phosphatase activity
GO:0034594 IDA:UniProtKB F phosphatidylinositol trisphosphate phosphatase activity
GO:0034485 IDA:UniProtKB F phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0005000 ISS:UniProtKB F vasopressin receptor activity
GO:0007186 ISS:UniProtKB P G-protein coupled receptor signaling pathway
GO:0030036 NAS:UniProtKB P actin cytoskeleton organization
GO:0071320 ISS:UniProtKB P cellular response to cAMP
GO:0071364 IDA:UniProtKB P cellular response to epidermal growth factor stimulus
GO:0032870 ISS:UniProtKB P cellular response to hormone stimulus
GO:0032869 IDA:UniProtKB P cellular response to insulin stimulus
GO:0071356 IDA:UniProtKB P cellular response to tumor necrosis factor
GO:0016311 IDA:GOC P dephosphorylation
GO:0042593 ISS:UniProtKB P glucose homeostasis
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0046855 IDA:MGI P inositol phosphate dephosphorylation
GO:0043922 IDA:UniProtKB P negative regulation by host of viral transcription
GO:0043407 IDA:UniProtKB P negative regulation of MAP kinase activity
GO:0051926 IDA:UniProtKB P negative regulation of calcium ion transport
GO:0035305 ISS:UniProtKB P negative regulation of dephosphorylation
GO:0010829 IDA:UniProtKB P negative regulation of glucose transport
GO:2000466 ISS:UniProtKB P negative regulation of glycogen (starch) synthase activity
GO:0045719 IDA:UniProtKB P negative regulation of glycogen biosynthetic process
GO:0046627 IDA:UniProtKB P negative regulation of insulin receptor signaling pathway
GO:0033137 IDA:UniProtKB P negative regulation of peptidyl-serine phosphorylation
GO:0010801 IDA:UniProtKB P negative regulation of peptidyl-threonine phosphorylation
GO:0051898 IDA:UniProtKB P negative regulation of protein kinase B signaling
GO:0006469 IDA:UniProtKB P negative regulation of protein kinase activity
GO:0001933 ISS:UniProtKB P negative regulation of protein phosphorylation
GO:0090315 IDA:UniProtKB P negative regulation of protein targeting to membrane
GO:0045869 IDA:UniProtKB P negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051497 IDA:UniProtKB P negative regulation of stress fiber assembly
GO:0045892 ISS:UniProtKB P negative regulation of transcription, DNA-templated
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0046856 IDA:UniProtKB P phosphatidylinositol dephosphorylation
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:2001153 ISS:UniProtKB P positive regulation of renal water transport
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0035810 ISS:UniProtKB P positive regulation of urine volume
GO:0072661 ISS:UniProtKB P protein targeting to plasma membrane
GO:0005979 ISS:UniProtKB P regulation of glycogen biosynthetic process
GO:0097178 IDA:UniProtKB P ruffle assembly
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04910 Insulin signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121025 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-5-phosphatase K
Protein Entry
Q9BT40_HUMAN
UniProt ID
Q9BT40
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q9BT40-1; Sequence=Displayed; Name=2 ; IsoId=Q9BT40-2; Sequence=VSP_050612;
Catalytic Activity D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
Function Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
Interaction Q8TBB1:LNX1; NbExp=3; IntAct=EBI-749162, EBI-739832;
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family.
Subcellular Location Endoplasmic reticulum . Note=Following stimulation with EGF, translocates to membrane ruffles.
Tissue Specificity Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002367 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18765709 RefSeq NP_057616 448 inositol polyphosphate 5-phosphatase K isoform 1
18765707 RefSeq NP_570122 372 inositol polyphosphate 5-phosphatase K isoform 2

Identical Sequences to LMP002367 proteins

Reference Database Accession Length Protein Name
GI:18765709 DBBJ BAG35697.1 448 unnamed protein product [Homo sapiens]
GI:18765707 DBBJ BAG35479.1 372 unnamed protein product [Homo sapiens]
GI:18765709 DBBJ BAI47330.1 448 SPHK1 interactor, AKAP domain containing, partial [synthetic construct]
GI:18765707 GenBank AAE27689.1 372 Sequence 1 from patent US 5955338
GI:18765707 GenBank EAW90614.1 372 skeletal muscle and kidney enriched inositol phosphatase, isoform CRA_a [Homo sapiens]
GI:18765709 GenBank EAW90618.1 448 skeletal muscle and kidney enriched inositol phosphatase, isoform CRA_b [Homo sapiens]
GI:18765709 GenBank ABM83741.1 448 skeletal muscle and kidney enriched inositol phosphatase [synthetic construct]
GI:18765709 GenBank ABM87060.1 448 skeletal muscle and kidney enriched inositol phosphatase, partial [synthetic construct]
GI:18765709 GenBank AIC51570.1 448 INPP5K, partial [synthetic construct]
GI:18765707 RefSeq NP_001129114.1 372 inositol polyphosphate 5-phosphatase K isoform 2 [Homo sapiens]
GI:18765707 RefSeq XP_005256740.1 372 PREDICTED: inositol polyphosphate 5-phosphatase K isoform X1 [Homo sapiens]
GI:18765707 RefSeq XP_006721608.1 372 PREDICTED: inositol polyphosphate 5-phosphatase K isoform X5 [Homo sapiens]

Related Sequences to LMP002367 proteins

Reference Database Accession Length Protein Name
GI:18765709 DBBJ BAA92340.1 448 skeletal muscle and kidney enriched inositol phosphatase [Homo sapiens]
GI:18765709 DBBJ BAA92342.1 448 skeletal muscle and kidney enriched inositol phosphatase [Homo sapiens]
GI:18765707 DBBJ BAG35697.1 448 unnamed protein product [Homo sapiens]
GI:18765707 GenBank AAH04362.1 448 Inositol polyphosphate-5-phosphatase K [Homo sapiens]
GI:18765707 GenBank EAW90615.1 448 skeletal muscle and kidney enriched inositol phosphatase, isoform CRA_b [Homo sapiens]
GI:18765709 GenBank EAW90617.1 449 skeletal muscle and kidney enriched inositol phosphatase, isoform CRA_d [Homo sapiens]
GI:18765707 GenBank EAW90618.1 448 skeletal muscle and kidney enriched inositol phosphatase, isoform CRA_b [Homo sapiens]
GI:18765709 GenBank JAA02130.1 448 inositol polyphosphate-5-phosphatase K [Pan troglodytes]
GI:18765709 GenBank JAA15825.1 448 inositol polyphosphate-5-phosphatase K [Pan troglodytes]
GI:18765709 GenBank JAA22725.1 448 inositol polyphosphate-5-phosphatase K [Pan troglodytes]
GI:18765707 RefSeq NP_057616.2 448 inositol polyphosphate 5-phosphatase K isoform 1 [Homo sapiens]
GI:18765707 SwissProt Q9BT40.3 448 RecName: Full=Inositol polyphosphate 5-phosphatase K; AltName: Full=Skeletal muscle and kidney-enriched inositol phosphatase [Homo sapiens]