Gene/Proteome Database (LMPD)

LMPD ID
LMP002369
Gene ID
51573
Species
Homo sapiens (Human)
Gene Name
glycerophosphodiester phosphodiesterase 1
Gene Symbol
GDE1
Synonyms
363E6.2; MIR16
Alternate Names
glycerophosphodiester phosphodiesterase 1; RGS16-interacting membrane protein; membrane interacting protein of RGS16; membrane-interacting protein of RGS16
Chromosome
16
Map Location
16p12-p11.2
EC Number
3.1.4.44

Proteins

glycerophosphodiester phosphodiesterase 1
Refseq ID NP_057725
Protein GI 7706617
UniProt ID Q9NZC3
mRNA ID NM_016641
Length 331
RefSeq Status VALIDATED
MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREAVAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESHLGSSYITDSMVEDCEPHF

Gene Information

Entrez Gene ID
51573
Gene Name
glycerophosphodiester phosphodiesterase 1
Gene Symbol
GDE1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016021 TAS:UniProtKB C integral component of membrane
GO:0008889 TAS:UniProtKB F glycerophosphodiester phosphodiesterase activity
GO:0047395 IEA:UniProtKB-EC F glycerophosphoinositol glycerophosphodiesterase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 TAS:UniProtKB P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase 1
Protein Entry
GDE1_HUMAN
UniProt ID
Q9NZC3
Species
Human

Comments

Comment Type Description
Catalytic Activity 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI
Function Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).
Ptm N-glycosylated.
Sequence Caution Sequence=AAC05440.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=AAC05803.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family.
Similarity Contains 1 GP-PDE domain.
Subcellular Location Cytoplasm . Membrane {ECO
Subunit Interacts with RGS16 (By similarity). Interacts with PRAF2.
Tissue Specificity Widely expressed.

Identical and Related Proteins

Unique RefSeq proteins for LMP002369 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7706617 RefSeq NP_057725 331 glycerophosphodiester phosphodiesterase 1

Identical Sequences to LMP002369 proteins

Reference Database Accession Length Protein Name
GI:7706617 EMBL CAJ42764.1 331 unnamed protein product [Homo sapiens]
GI:7706617 GenBank EAW50284.1 331 membrane interacting protein of RGS16, isoform CRA_b [Homo sapiens]
GI:7706617 GenBank ACE23758.1 331 Sequence 8990 from patent US 7368531
GI:7706617 GenBank ACH34509.1 331 Sequence 8990 from patent US 7411051
GI:7706617 GenBank AIC51528.1 331 GDE1, partial [synthetic construct]
GI:7706617 SwissProt Q9NZC3.1 331 RecName: Full=Glycerophosphodiester phosphodiesterase 1; AltName: Full=Membrane-interacting protein of RGS16; AltName: Full=RGS16-interacting membrane protein [Homo sapiens]

Related Sequences to LMP002369 proteins

Reference Database Accession Length Protein Name
GI:7706617 EMBL CAI93392.1 331 unnamed protein product [Homo sapiens]
GI:7706617 EMBL CAM55990.1 331 unnamed protein product [Homo sapiens]
GI:7706617 GenBank AAE86187.1 331 Sequence 116 from patent US 6312922
GI:7706617 GenBank ABA37896.1 331 Sequence 116 from patent US 6936692
GI:7706617 GenBank ABH92272.1 331 Sequence 243 from patent US 7060479
GI:7706617 GenBank ACM84776.1 364 Sequence 10274 from patent US 6812339