Gene/Proteome Database (LMPD)

LMPD ID
LMP002380
Gene ID
10390
Species
Homo sapiens (Human)
Gene Name
choline/ethanolamine phosphotransferase 1
Gene Symbol
CEPT1
Synonyms
-
Chromosome
1
Map Location
1p13.3
EC Number
2.7.8.1
Summary
Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine by the transfer of phosphocholine from CDP-choline to diacylglycerol. The synthesis of phosphatidylethanolamine by ethanolaminephosphotransferase occurs using an analogous reaction. This gene codes for a choline/ethanolaminephosphotransferase. The protein can synthesize either choline- or ethanolamine- containing phospholipids. Two alternatively spliced transcripts encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CEPT1

Proteins

choline/ethanolaminephosphotransferase 1
Refseq ID NP_006081
Protein GI 5174415
UniProt ID Q9Y6K0
mRNA ID NM_006090
Length 416
RefSeq Status REVIEWED
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH
choline/ethanolaminephosphotransferase 1
Refseq ID NP_001007795
Protein GI 56118223
UniProt ID Q9Y6K0
mRNA ID NM_001007794
Length 416
RefSeq Status REVIEWED
Protein sequence is identical to GI:5174415 (mRNA isoform)

Gene Information

Entrez Gene ID
10390
Gene Name
choline/ethanolamine phosphotransferase 1
Gene Symbol
CEPT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 TAS:ProtInc C integral component of membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004142 TAS:Reactome F diacylglycerol cholinephosphotransferase activity
GO:0004307 TAS:ProtInc F ethanolaminephosphotransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006657 TAS:GOC P CDP-choline pathway
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0006656 TAS:Reactome P phosphatidylcholine biosynthetic process
GO:0006646 TAS:Reactome P phosphatidylethanolamine biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121238 Synthesis of PC
REACT_120919 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014472 Choline/ethanolamine phosphotransferase

UniProt Annotations

Entry Information

Gene Name
choline/ethanolamine phosphotransferase 1
Protein Entry
CEPT1_HUMAN
UniProt ID
Q9Y6K0
Species
Human

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=37 uM for CDP-choline {ECO
Catalytic Activity CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
Catalytic Activity CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
Cofactor Name=Mg(2+); Xref=ChEBI
Function Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Sequence Caution Sequence=AAF61194.1; Type=Frameshift; Positions=276; Evidence= ;
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein .
Tissue Specificity Ubiquitously expressed.

Identical and Related Proteins

Unique RefSeq proteins for LMP002380 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5174415 RefSeq NP_006081 416 choline/ethanolaminephosphotransferase 1

Identical Sequences to LMP002380 proteins

Reference Database Accession Length Protein Name
GI:5174415 GenBank AIC55761.1 416 CEPT1, partial [synthetic construct]
GI:5174415 RefSeq XP_007975799.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X3 [Chlorocebus sabaeus]
GI:5174415 RefSeq XP_008961248.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 [Pan paniscus]
GI:5174415 RefSeq XP_009213365.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Papio anubis]
GI:5174415 RefSeq XP_009427832.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Pan troglodytes]
GI:5174415 RefSeq XP_009427839.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Pan troglodytes]

Related Sequences to LMP002380 proteins

Reference Database Accession Length Protein Name
GI:5174415 GenBank EHH15045.1 416 hypothetical protein EGK_01079 [Macaca mulatta]
GI:5174415 GenBank EHH50152.1 416 hypothetical protein EGM_00931 [Macaca fascicularis]
GI:5174415 GenBank AFE64278.1 416 choline/ethanolaminephosphotransferase 1 [Macaca mulatta]
GI:5174415 GenBank AFH30196.1 416 choline/ethanolaminephosphotransferase 1 [Macaca mulatta]
GI:5174415 GenBank AFI34665.1 416 choline/ethanolaminephosphotransferase 1 [Macaca mulatta]
GI:5174415 RefSeq XP_007975793.1 454 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Chlorocebus sabaeus]