Gene/Proteome Database (LMPD)

LMPD ID
LMP002389
Gene ID
71147
Species
Mus musculus (Mouse)
Gene Name
3-oxoacyl-ACP synthase, mitochondrial
Gene Symbol
Oxsm
Synonyms
4933425A18Rik; C80494
Alternate Names
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; beta-ketoacyl-ACP synthase
Chromosome
14
Map Location
14 A2|14
EC Number
2.3.1.41

Proteins

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor
Refseq ID NP_081971
Protein GI 58037235
UniProt ID Q9D404
mRNA ID NM_027695
Length 459
RefSeq Status PROVISIONAL
MLSKCLQHFLKATISHPYPASYSWLISKHRFYGTVPAAMLRRRVVITGIGLVTPLGVGTQLVWDRLLRGESGIVSVVGDEYKNIPCSVAAYVPRGPHEGQFNEENFVSKSDAKSMSSSTIMAVGAAELALKDSGWHPKREADQVATGVAIGMGMVPLEVISETALLFQTKGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSSNPDPKLACRPFHPERDGFVMGEGAAVLVLEEHEHAVQRGARIYAEILGYGLSGDAGHITAPDPEGEGALRCMAAAVKDAGVSPEQISYVNAHATSTPLGDAAENRAIKRLFRDHACALAISSTKGATGHLLGAAGAVEATFTALACYHQKLPPTLNLDCTEPEFDLNYVPLESQEWKAEGRCIGLTNSFGFGGTNATLCIAGM
transit_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9D404.1) calculated_mol_wt: 3123 peptide sequence: MLSKCLQHFLKATISHPYPASYSWLIS mat_peptide: 28..459 product: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9D404.1) calculated_mol_wt: 45523 peptide sequence: KHRFYGTVPAAMLRRRVVITGIGLVTPLGVGTQLVWDRLLRGESGIVSVVGDEYKNIPCSVAAYVPRGPHEGQFNEENFVSKSDAKSMSSSTIMAVGAAELALKDSGWHPKREADQVATGVAIGMGMVPLEVISETALLFQTKGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSSNPDPKLACRPFHPERDGFVMGEGAAVLVLEEHEHAVQRGARIYAEILGYGLSGDAGHITAPDPEGEGALRCMAAAVKDAGVSPEQISYVNAHATSTPLGDAAENRAIKRLFRDHACALAISSTKGATGHLLGAAGAVEATFTALACYHQKLPPTLNLDCTEPEFDLNYVPLESQEWKAEGRCIGLTNSFGFGGTNATLCIAGM

Gene Information

Entrez Gene ID
71147
Gene Name
3-oxoacyl-ACP synthase, mitochondrial
Gene Symbol
Oxsm
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 ISS:HGNC C mitochondrion
GO:0004315 ISS:HGNC F 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0006637 ISS:HGNC P acyl-CoA metabolic process
GO:0051792 ISS:HGNC P medium-chain fatty acid biosynthetic process
GO:0051790 ISS:HGNC P short-chain fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00780 Biotin metabolism
mmu00061 Fatty acid biosynthesis
mmu01212 Fatty acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2
IPR014031 Beta-ketoacyl synthase, C-terminal
IPR014030 Beta-ketoacyl synthase, N-terminal
IPR018201 Beta-ketoacyl synthase, active site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
3-oxoacyl-ACP synthase, mitochondrial
Protein Entry
OXSM_MOUSE
UniProt ID
Q9D404
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
Enzyme Regulation Inhibited by cerulenin. {ECO:0000250}.
Function May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. {ECO:0000250}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the beta-ketoacyl-ACP synthases family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002389 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58037235 RefSeq NP_081971 459 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

Identical Sequences to LMP002389 proteins

Reference Database Accession Length Protein Name
GI:58037235 EMBL CBN70681.1 459 unnamed protein product [Mus musculus]
GI:58037235 EMBL CBN69073.1 459 unnamed protein product [Mus musculus]
GI:58037235 RefSeq XP_006518163.1 459 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1 [Mus musculus]
GI:58037235 RefSeq XP_006518164.1 459 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X2 [Mus musculus]
GI:58037235 RefSeq XP_006518165.1 459 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X3 [Mus musculus]
GI:58037235 RefSeq XP_006518166.1 459 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X4 [Mus musculus]

Related Sequences to LMP002389 proteins

Reference Database Accession Length Protein Name
GI:58037235 GenBank AAI18052.1 459 3-oxoacyl-ACP synthase, mitochondrial [Mus musculus]
GI:58037235 GenBank AAI19794.1 459 3-oxoacyl-ACP synthase, mitochondrial [Mus musculus]
GI:58037235 GenBank EDL20640.1 462 3-oxoacyl-ACP synthase, mitochondrial, isoform CRA_b, partial [Mus musculus]
GI:58037235 GenBank EDL94095.1 456 rCG42150 [Rattus norvegicus]
GI:58037235 RefSeq NP_001093978.1 456 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Rattus norvegicus]
GI:58037235 RefSeq XP_006251773.1 456 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1 [Rattus norvegicus]