Gene/Proteome Database (LMPD)

LMPD ID
LMP002399
Gene ID
227671
Species
Mus musculus (Mouse)
Gene Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Gene Symbol
Gbgt1
Synonyms
Fgs; Fs
Alternate Names
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; forssman glycolipid synthase; forssman glycolipid synthetase
Chromosome
2
Map Location
2 A3|2
EC Number
2.4.1.88

Proteins

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Refseq ID NP_631936
Protein GI 254587968
UniProt ID Q8VI38
mRNA ID NM_139197
Length 347
RefSeq Status VALIDATED
MTRPRLAQGLAFFLLGGTGLWVLWKFIKDWLLVSYIPYYLPCPEFFNMKLPFRKEKPLQPVTQLQYPQPKLLEHGPTELLTLTPWLAPIVSEGTFDPELLKSMYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFTHDPTAVPRVPLGPGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPETLGDLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFTRACHMAILADKANSIMAAWQEESHLNRHFIWHKPSKVLSPEYLWDERKPRPRSLKMIRFSSVKKNANWLRT

Gene Information

Entrez Gene ID
227671
Gene Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Gene Symbol
Gbgt1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 TAS:UniProtKB C membrane
GO:0047277 IDA:UniProtKB F globoside alpha-N-acetylgalactosaminyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0030259 TAS:UniProtKB P lipid glycosylation
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00603 Glycosphingolipid biosynthesis - globo series
mmu00603 Glycosphingolipid biosynthesis - globo series
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR005076 Glycosyl transferase, family 6
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Protein Entry
GBGT1_MOUSE
UniProt ID
Q8VI38
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-alpha-D-galactosamine + N-acetyl- D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D- glucosyl-(1<->1)-ceramide = UDP + N-acetyl-D-galactosaminyl- (1->3)-N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D- galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Domain The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). {ECO:0000250}.
Function Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens. Conversely, it diminishes Shiga toxins susceptibility. {ECO:0000269|PubMed:14573676}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 6 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/search/jsp/landing.jsp?query=gt_mou_504";

Identical and Related Proteins

Unique RefSeq proteins for LMP002399 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
254587968 RefSeq NP_631936 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Identical Sequences to LMP002399 proteins

Reference Database Accession Length Protein Name
GI:254587968 GenBank AAI06832.1 347 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Mus musculus]
GI:254587968 GenBank EDL08384.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Mus musculus]
GI:254587968 RefSeq XP_006497981.1 347 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1 [Mus musculus]
GI:254587968 RefSeq XP_006497982.1 347 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2 [Mus musculus]
GI:254587968 RefSeq XP_006497983.1 347 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X3 [Mus musculus]
GI:254587968 SwissProt Q8VI38.2 347 RecName: Full=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; AltName: Full=Forssman glycolipid synthase [Mus musculus]

Related Sequences to LMP002399 proteins

Reference Database Accession Length Protein Name
GI:254587968 DBBJ BAC23060.2 347 forssman glycolipid synthetase [Mus musculus]
GI:254587968 GenBank AAL37034.1 347 Forssman glycolipid synthetase [Mus musculus]
GI:254587968 RefSeq XP_005085473.1 346 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1 [Mesocricetus auratus]
GI:254587968 RefSeq XP_005346253.1 347 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Microtus ochrogaster]
GI:254587968 RefSeq XP_006497985.1 300 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X5 [Mus musculus]
GI:254587968 RefSeq XP_006993161.1 347 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1-like [Peromyscus maniculatus bairdii]