Gene/Proteome Database (LMPD)

LMPD ID
LMP002418
Gene ID
7108
Species
Homo sapiens (Human)
Gene Name
transmembrane 7 superfamily member 2
Gene Symbol
TM7SF2
Synonyms
ANG1; DHCR14A; NET47
Alternate Names
delta(14)-sterol reductase; delta-14-SR; sterol C14-reductase; C-14 sterol reductase; another new gene 1 protein; putative sterol reductase SR-1
Chromosome
11
Map Location
11q13
EC Number
1.3.1.70

Proteins

delta(14)-sterol reductase isoform 1
Refseq ID NP_003264
Protein GI 117414150
UniProt ID O76062
mRNA ID NM_003273
Length 418
RefSeq Status VALIDATED
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
delta(14)-sterol reductase isoform 2
Refseq ID NP_001264162
Protein GI 469663653
UniProt ID O76062
mRNA ID NM_001277233
Length 391
RefSeq Status VALIDATED
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY

Gene Information

Entrez Gene ID
7108
Gene Name
transmembrane 7 superfamily member 2
Gene Symbol
TM7SF2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 TAS:ProtInc C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0043235 IDA:MGI C receptor complex
GO:0050613 IEA:UniProtKB-EC F delta14-sterol reductase activity
GO:0006695 TAS:Reactome P cholesterol biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6074 zymosterol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_147904 Activation of gene expression by SREBF (SREBP)
REACT_9405 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001171 Ergosterol biosynthesis ERG4/ERG24
IPR018083 Sterol reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
transmembrane 7 superfamily member 2
Protein Entry
ERG24_HUMAN
UniProt ID
O76062
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O76062-1; Sequence=Displayed; Name=2; IsoId=O76062-2; Sequence=VSP_017898; Note=No experimental confirmation available.;
Catalytic Activity 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3- beta-ol + NADP(+) = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3- beta-ol + NADPH.
Function Involved in the conversion of lanosterol to cholesterol.
Sequence Caution Sequence=AAC21450.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence= ; Sequence=AAC21457.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence= ;
Similarity Belongs to the ERG4/ERG24 family.
Subcellular Location Microsome membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.

Identical and Related Proteins

Unique RefSeq proteins for LMP002418 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
117414150 RefSeq NP_003264 418 delta(14)-sterol reductase isoform 1
469663653 RefSeq NP_001264162 391 delta(14)-sterol reductase isoform 2

Identical Sequences to LMP002418 proteins

Reference Database Accession Length Protein Name
GI:117414150 GenBank AAH09052.1 418 Transmembrane 7 superfamily member 2 [Homo sapiens]
GI:117414150 GenBank EAW74348.1 418 transmembrane 7 superfamily member 2, isoform CRA_a [Homo sapiens]
GI:469663653 GenBank EAW74349.1 391 transmembrane 7 superfamily member 2, isoform CRA_b [Homo sapiens]
GI:117414150 GenBank EAW74351.1 418 transmembrane 7 superfamily member 2, isoform CRA_a [Homo sapiens]
GI:117414150 GenBank AIC63192.1 418 TM7SF2, partial [synthetic construct]
GI:117414150 SwissProt O76062.3 418 RecName: Full=Delta(14)-sterol reductase; Short=Delta-14-SR; AltName: Full=Another new gene 1 protein; AltName: Full=C-14 sterol reductase; AltName: Full=Putative sterol reductase SR-1; AltName: Full=Sterol C14-reductase; AltName: Full=Transmembrane 7 superfamily member 2 [Homo sapiens]

Related Sequences to LMP002418 proteins

Reference Database Accession Length Protein Name
GI:117414150 DBBJ BAF83624.1 418 unnamed protein product [Homo sapiens]
GI:117414150 GenBank AAD09765.1 418 putative sterol reductase SR-1 [Homo sapiens]
GI:469663653 GenBank AAD09765.1 418 putative sterol reductase SR-1 [Homo sapiens]
GI:117414150 GenBank AAD09769.1 418 putative sterol reductase SR-1 [Homo sapiens]
GI:469663653 GenBank AAD09769.1 418 putative sterol reductase SR-1 [Homo sapiens]
GI:117414150 GenBank AAE84288.1 418 Sequence 7 from patent US 6306632
GI:469663653 GenBank AAH38353.1 391 TM7SF2 protein [Homo sapiens]
GI:469663653 GenBank ACP87610.1 418 Sequence 252 from patent US 7504211
GI:117414150 GenBank ACP87610.1 418 Sequence 252 from patent US 7504211
GI:469663653 GenBank AIC55251.1 418 TM7SF2, partial [synthetic construct]
GI:117414150 GenBank AIC55251.1 418 TM7SF2, partial [synthetic construct]
GI:469663653 RefSeq XP_004051532.1 391 PREDICTED: delta(14)-sterol reductase isoform 2 [Gorilla gorilla gorilla]