Gene/Proteome Database (LMPD)

LMPD ID
LMP002426
Gene ID
6439
Species
Homo sapiens (Human)
Gene Name
surfactant protein B
Gene Symbol
SFTPB
Synonyms
PSP-B; SFTB3; SFTP3; SMDP1; SP-B
Chromosome
2
Map Location
2p12-p11.2
Summary
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
Orthologs
View orthologs and multiple alignments for SFTPB

Proteins

pulmonary surfactant-associated protein B precursor
Refseq ID NP_942140
Protein GI 288856297
UniProt ID P07988
mRNA ID NM_198843
Length 393
RefSeq Status REVIEWED
MHQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAAWTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVIDYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPKGALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL
sig_peptide: 1..36 calculated_mol_wt: 3779 peptide sequence: MHQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAA mat_peptide: 37..393 product: pulmonary surfactant-associated protein B calculated_mol_wt: 39586 peptide sequence: WTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVIDYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPKGALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL sig_peptide: 1..36 calculated_mol_wt: 3779 peptide sequence: MHQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAA mat_peptide: 37..393 product: pulmonary surfactant-associated protein B calculated_mol_wt: 39586 peptide sequence: WTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVIDYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPKGALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL
pulmonary surfactant-associated protein B precursor
Refseq ID NP_000533
Protein GI 288856299
UniProt ID P07988
mRNA ID NM_000542
Length 393
RefSeq Status REVIEWED
Protein sequence is identical to GI:288856297 (mRNA isoform)

Gene Information

Entrez Gene ID
6439
Gene Name
surfactant protein B
Gene Symbol
SFTPB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IEA:InterPro C lysosome
GO:0006665 IEA:InterPro P sphingolipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR008373 Saposin
IPR008139 Saposin B
IPR003119 Saposin type A
IPR011001 Saposin-like
IPR007856 Saposin-like type B, 1
IPR008138 Saposin-like type B, 2

UniProt Annotations

Entry Information

Gene Name
surfactant protein B
Protein Entry
PSPB_HUMAN
UniProt ID
P07988
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002426 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
288856297 RefSeq NP_942140 393 pulmonary surfactant-associated protein B precursor

Identical Sequences to LMP002426 proteins

Reference Database Accession Length Protein Name
GI:288856297 GenBank EAW99487.1 393 surfactant, pulmonary-associated protein B, isoform CRA_a [Homo sapiens]
GI:288856297 GenBank EAW99488.1 393 surfactant, pulmonary-associated protein B, isoform CRA_a [Homo sapiens]
GI:288856297 GenBank EAW99489.1 393 surfactant, pulmonary-associated protein B, isoform CRA_a [Homo sapiens]
GI:288856297 RefSeq NP_000533.3 393 pulmonary surfactant-associated protein B precursor [Homo sapiens]
GI:288856297 RefSeq XP_005264544.1 393 PREDICTED: pulmonary surfactant-associated protein B isoform X1 [Homo sapiens]

Related Sequences to LMP002426 proteins

Reference Database Accession Length Protein Name
GI:288856297 RefSeq XP_003816622.1 393 PREDICTED: pulmonary surfactant-associated protein B [Pan paniscus]
GI:288856297 RefSeq XP_003816624.1 393 PREDICTED: pulmonary surfactant-associated protein B [Pan paniscus]
GI:288856297 RefSeq XP_004029603.1 393 PREDICTED: pulmonary surfactant-associated protein B isoform 2 [Gorilla gorilla gorilla]
GI:288856297 RefSeq XP_005264545.1 389 PREDICTED: pulmonary surfactant-associated protein B isoform X2 [Homo sapiens]
GI:288856297 RefSeq XP_005264546.1 389 PREDICTED: pulmonary surfactant-associated protein B isoform X3 [Homo sapiens]
GI:288856297 RefSeq XP_008967863.1 393 PREDICTED: pulmonary surfactant-associated protein B [Pan paniscus]