Gene/Proteome Database (LMPD)

LMPD ID
LMP002427
Gene ID
259230
Species
Homo sapiens (Human)
Gene Name
sphingomyelin synthase 1
Gene Symbol
SGMS1
Synonyms
MOB; MOB1; SMS1; TMEM23; hmob33
Chromosome
10
Map Location
10q11.2
Summary
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SGMS1

Proteins

phosphatidylcholine:ceramide cholinephosphotransferase 1
Refseq ID NP_671512
Protein GI 29789379
UniProt ID Q86VZ5
mRNA ID NM_147156
Length 413
RefSeq Status REVIEWED
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT

Gene Information

Entrez Gene ID
259230
Gene Name
sphingomyelin synthase 1
Gene Symbol
SGMS1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0071222 IEA:Ensembl P cellular response to lipopolysaccharide
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0006954 IEA:Ensembl P inflammatory response
GO:2001237 IEA:Ensembl P negative regulation of extrinsic apoptotic signaling pathway
GO:0010628 IEA:Ensembl P positive regulation of gene expression

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11281 sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_115810 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR025749 Sphingomyelin synthase-like domain
IPR001660 Sterile alpha motif domain
IPR021129 Sterile alpha motif, type 1
IPR013761 Sterile alpha motif/pointed domain

UniProt Annotations

Entry Information

Gene Name
sphingomyelin synthase 1
Protein Entry
D3DWC4_HUMAN
UniProt ID
Q86VZ5
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002427 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
29789379 RefSeq NP_671512 413 phosphatidylcholine:ceramide cholinephosphotransferase 1

Identical Sequences to LMP002427 proteins

Reference Database Accession Length Protein Name
GI:29789379 GenBank AHD71947.1 413 Sequence 6641 from patent US 8586006
GI:29789379 RefSeq XP_005565923.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X10 [Macaca fascicularis]
GI:29789379 RefSeq XP_005565924.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X11 [Macaca fascicularis]
GI:29789379 RefSeq XP_007961645.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Chlorocebus sabaeus]
GI:29789379 RefSeq XP_007961646.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Chlorocebus sabaeus]
GI:29789379 RefSeq XP_007961647.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Chlorocebus sabaeus]

Related Sequences to LMP002427 proteins

Reference Database Accession Length Protein Name
GI:29789379 RefSeq XP_003255211.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform 1 [Nomascus leucogenys]
GI:29789379 RefSeq XP_008963324.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Pan paniscus]
GI:29789379 RefSeq XP_010377935.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Rhinopithecus roxellana]
GI:29789379 RefSeq XP_010377936.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Rhinopithecus roxellana]
GI:29789379 RefSeq XP_010377937.1 413 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 1 [Rhinopithecus roxellana]
GI:29789379 SwissProt Q86VZ5.2 419 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Medulla oblongata-derived protein; Short=Protein Mob; AltName: Full=Sphingomyelin synthase 1; AltName: Full=Transmembrane protein 23 [Homo sapiens]