Gene/Proteome Database (LMPD)

LMPD ID
LMP002438
Gene ID
126129
Species
Homo sapiens (Human)
Gene Name
carnitine palmitoyltransferase 1C
Gene Symbol
CPT1C
Synonyms
CATL1; CPT1-B; CPT1P; CPTI-B; CPTIC
Alternate Names
carnitine O-palmitoyltransferase 1, brain isoform; carnitine palmitoyltransferase I related C; carnitine O-palmitoyltransferase I, brain isoform
Chromosome
19
Map Location
19q13.33
EC Number
2.3.1.21
Summary
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Orthologs
View orthologs and multiple alignments for CPT1C

Proteins

carnitine O-palmitoyltransferase 1, brain isoform isoform 1
Refseq ID NP_001129524
Protein GI 209862905
UniProt ID Q8TCG5
mRNA ID NM_001136052
Length 792
RefSeq Status REVIEWED
MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGALIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNPLMVNSNYYMMAARAGNAVHALLLYRHRLNRQEIPPTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSRNSLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAAEALEAVEGAAFFVSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENSRHRCGFLSRQTGASKASMTSTDF
carnitine O-palmitoyltransferase 1, brain isoform isoform 2
Refseq ID NP_689572
Protein GI 22748777
UniProt ID Q8TCG5
mRNA ID NM_152359
Length 803
RefSeq Status REVIEWED
MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGALIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNPLMVNSNYYMMDFLYVTPTPLQAARAGNAVHALLLYRHRLNRQEIPPTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSRNSLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAAEALEAVEGAAFFVSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENSRHRCGFLSRQTGASKASMTSTDF
carnitine O-palmitoyltransferase 1, brain isoform isoform 2
Refseq ID NP_001186681
Protein GI 315221117
UniProt ID Q8TCG5
mRNA ID NM_001199752
Length 803
RefSeq Status REVIEWED
Protein sequence is identical to GI:22748777 (mRNA isoform)
carnitine O-palmitoyltransferase 1, brain isoform isoform 2
Refseq ID NP_001186682
Protein GI 315221119
UniProt ID Q8TCG5
mRNA ID NM_001199753
Length 803
RefSeq Status REVIEWED
Protein sequence is identical to GI:22748777 (mRNA isoform)

Gene Information

Entrez Gene ID
126129
Gene Name
carnitine palmitoyltransferase 1C
Gene Symbol
CPT1C
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0032281 IEA:Ensembl C alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0045202 IEA:UniProtKB-KW C synapse
GO:0004095 IEA:UniProtKB-EC F carnitine O-palmitoyltransferase activity
GO:0009437 IEA:Ensembl P carnitine metabolic process
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa04920 Adipocytokine signaling pathway
hsa03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine palmitoyltransferase 1C
Protein Entry
CPT1C_HUMAN
UniProt ID
Q8TCG5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCG5-1; Sequence=Displayed; Name=2; IsoId=Q8TCG5-2; Sequence=VSP_010677; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCG5-3; Sequence=VSP_012457; Note=No experimental confirmation available.;
Catalytic Activity Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Sequence Caution Sequence=BAB85068.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAD38561.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the carnitine/choline acetyltransferase family.
Subcellular Location Mitochondrion outer membrane ; Multi-pass membrane protein . Cell junction, synapse .
Subunit Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).
Tissue Specificity Expressed predominantly in brain and testis.

Identical and Related Proteins

Unique RefSeq proteins for LMP002438 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
209862905 RefSeq NP_001129524 792 carnitine O-palmitoyltransferase 1, brain isoform isoform 1
22748777 RefSeq NP_689572 803 carnitine O-palmitoyltransferase 1, brain isoform isoform 2

Identical Sequences to LMP002438 proteins

Reference Database Accession Length Protein Name
GI:22748777 DBBJ BAF82781.1 803 unnamed protein product [Homo sapiens]
GI:209862905 GenBank AAH29104.1 792 CPT1C protein [Homo sapiens]
GI:209862905 GenBank EAW52523.1 792 carnitine palmitoyltransferase 1C, isoform CRA_a [Homo sapiens]
GI:209862905 GenBank EAW52530.1 792 carnitine palmitoyltransferase 1C, isoform CRA_a [Homo sapiens]
GI:209862905 GenBank ABM82478.1 792 carnitine palmitoyltransferase 1C [synthetic construct]
GI:209862905 GenBank ABM85665.1 792 carnitine palmitoyltransferase 1C, partial [synthetic construct]
GI:22748777 GenBank AHD70370.1 803 Sequence 3045 from patent US 8586006
GI:22748777 RefSeq NP_001186681.1 803 carnitine O-palmitoyltransferase 1, brain isoform isoform 2 [Homo sapiens]
GI:22748777 RefSeq NP_001186682.1 803 carnitine O-palmitoyltransferase 1, brain isoform isoform 2 [Homo sapiens]
GI:22748777 RefSeq XP_005258562.1 803 PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [Homo sapiens]
GI:22748777 RefSeq XP_005258563.1 803 PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X2 [Homo sapiens]

Related Sequences to LMP002438 proteins

Reference Database Accession Length Protein Name
GI:22748777 DBBJ BAF82402.1 803 unnamed protein product [Homo sapiens]
GI:22748777 EMBL CAC88591.1 803 unnamed protein product [Homo sapiens]
GI:209862905 GenBank AAP66246.1 803 Sequence 12 from patent US 6558935
GI:209862905 GenBank AAQ14875.1 803 carnitine acyltransferase-like protein 1 [Homo sapiens]
GI:209862905 GenBank EAW52524.1 803 carnitine palmitoyltransferase 1C, isoform CRA_b [Homo sapiens]
GI:22748777 GenBank ABY09439.1 803 Sequence 10 from patent US 7301016
GI:22748777 GenBank ADS47644.1 803 Sequence 10 from patent US 7799898
GI:22748777 GenBank AFQ88717.1 803 Sequence 10 from patent US 8252915
GI:22748777 GenBank JAA09982.1 803 carnitine palmitoyltransferase 1C [Pan troglodytes]
GI:209862905 GenBank AHD70370.1 803 Sequence 3045 from patent US 8586006
GI:209862905 RefSeq XP_005258563.1 803 PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X2 [Homo sapiens]
GI:209862905 SwissProt Q8TCG5.1 803 RecName: Full=Carnitine O-palmitoyltransferase 1, brain isoform; Short=CPT1-B; AltName: Full=CPT IC; AltName: Full=Carnitine O-palmitoyltransferase I, brain isoform; Short=CPTI-B; AltName: Full=Carnitine palmitoyltransferase 1C [Homo sapiens]