Gene/Proteome Database (LMPD)

LMPD ID
LMP002440
Gene ID
13075
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Gene Symbol
Cyp19a1
Synonyms
Ar; ArKO; Cyp19; Int-5; Int5; p450arom
Alternate Names
aromatase; CYPXIX; estrogen synthase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, 19, aromatase
Chromosome
9
Map Location
9 A5.3|9 29.49 cM
EC Number
1.14.14.14

Proteins

aromatase
Refseq ID NP_031836
Protein GI 6681099
UniProt ID P28649
mRNA ID NM_007810
Length 503
RefSeq Status PROVISIONAL
MFLEMLNPMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPLDESAIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRNSDKYLQQ

Gene Information

Entrez Gene ID
13075
Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Gene Symbol
Cyp19a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0070330 ISS:UniProtKB F aromatase activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016712 IDA:MGI F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0008209 IMP:MGI P androgen metabolic process
GO:0060736 IMP:MGI P prostate gland growth

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR017972 Cytochrome P450, conserved site
IPR002401 Cytochrome P450, E-class, group I

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Protein Entry
CP19A_MOUSE
UniProt ID
P28649
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Androst-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins = estrone + formate + 4 H(2)O + 3 oxidized flavoproteins.
Catalytic Activity Testosterone + 3 O(2) + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP002440 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6681099 RefSeq NP_031836 503 aromatase

Identical Sequences to LMP002440 proteins

Reference Database Accession Length Protein Name
GI:6681099 DBBJ BAE25342.1 503 unnamed protein product [Mus musculus]
GI:6681099 GenBank AAI04490.1 503 Cytochrome P450, family 19, subfamily a, polypeptide 1 [Mus musculus]
GI:6681099 GenBank EDL25809.1 503 cytochrome P450, family 19, subfamily a, polypeptide 1 [Mus musculus]
GI:6681099 RefSeq XP_006510868.1 503 PREDICTED: cytochrome P450 19A1 isoform X1 [Mus musculus]
GI:6681099 RefSeq XP_006510869.1 503 PREDICTED: cytochrome P450 19A1 isoform X2 [Mus musculus]
GI:6681099 RefSeq XP_006510870.1 503 PREDICTED: cytochrome P450 19A1 isoform X3 [Mus musculus]

Related Sequences to LMP002440 proteins

Reference Database Accession Length Protein Name
GI:6681099 GenBank EDL95528.1 503 cytochrome P450, family 19, subfamily a, polypeptide 1, isoform CRA_a [Rattus norvegicus]
GI:6681099 GenBank ERE76914.1 503 cytochrome P450 19A1-like protein [Cricetulus griseus]
GI:6681099 RefSeq NP_058781.2 503 aromatase [Rattus norvegicus]
GI:6681099 RefSeq XP_003508831.1 503 PREDICTED: aromatase [Cricetulus griseus]
GI:6681099 RefSeq XP_006971648.1 504 PREDICTED: aromatase-like [Peromyscus maniculatus bairdii]
GI:6681099 RefSeq XP_007616047.1 503 PREDICTED: aromatase [Cricetulus griseus]