Gene/Proteome Database (LMPD)

LMPD ID
LMP002444
Gene ID
1798
Species
Homo sapiens (Human)
Gene Name
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Gene Symbol
DPAGT1
Synonyms
ALG7; CDG-Ij; CDG1J; CMSTA2; D11S366; DGPT; DPAGT; DPAGT2; G1PT; GPT; UAGT; UGAT
Alternate Names
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; GlcNAc-1-P transferase; N-acetylglucosamine-1-phosphate transferase; dolichyl-phosphate alpha-N-acetylglucosaminyltransferase; UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra
Chromosome
11
Map Location
11q23.3
EC Number
2.7.8.15
Summary
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for DPAGT1

Proteins

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Refseq ID NP_001373
Protein GI 42794009
UniProt ID Q9H3H5
mRNA ID NM_001382
Length 408
RefSeq Status REVIEWED
MWAFSELPMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITFSIRYQLVRLFYDV

Gene Information

Entrez Gene ID
1798
Gene Name
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Gene Symbol
DPAGT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:UniProtKB C endoplasmic reticulum membrane
GO:0030176 ISS:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0016021 ISS:UniProtKB C integral component of membrane
GO:0043231 IDA:UniProtKB C intracellular membrane-bounded organelle
GO:0016020 IDA:UniProtKB C membrane
GO:0003975 IDA:UniProtKB F UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0008963 IEA:InterPro F phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0016757 IEA:UniProtKB-KW F transferase activity, transferring glycosyl groups
GO:0006047 IEA:Ensembl P UDP-N-acetylglucosamine metabolic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0019408 IDA:UniProtKB P dolichol biosynthetic process
GO:0006488 TAS:Reactome P dolichol-linked oligosaccharide biosynthetic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0006487 IMP:UniProtKB P protein N-linked glycosylation
GO:0018279 TAS:Reactome P protein N-linked glycosylation via asparagine
GO:0051259 ISS:UniProtKB P protein oligomerization

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00510 N-Glycan biosynthesis
ko00510 N-Glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR000715 Glycosyl transferase, family 4

UniProt Annotations

Entry Information

Gene Name
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Protein Entry
GPT_HUMAN
UniProt ID
Q9H3H5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H3H5-1; Sequence=Displayed; Name=2; IsoId=Q9H3H5-2; Sequence=VSP_001803; Note=No experimental confirmation available.; Name=3; IsoId=Q9H3H5-3; Sequence=VSP_008886; Note=No experimental confirmation available.;
Catalytic Activity UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
Disease Congenital disorder of glycosylation 1J (CDG1J) [MIM
Disease Myasthenic syndrome, congenital, with tubular aggregates, 2 (CMSTA2) [MIM
Function Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 4 family.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=UDP- N-acetylglucosamine--dolichyl-phosphate N- acetylglucosaminephosphotransferase; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_543";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=DPAGT1";

Identical and Related Proteins

Unique RefSeq proteins for LMP002444 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42794009 RefSeq NP_001373 408 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Identical Sequences to LMP002444 proteins

Reference Database Accession Length Protein Name
GI:42794009 GenBank EAW67453.1 408 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a [Homo sapiens]
GI:42794009 GenBank EAW67454.1 408 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a [Homo sapiens]
GI:42794009 GenBank EAW67455.1 408 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a [Homo sapiens]
GI:42794009 GenBank ADQ31680.1 408 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra, partial [synthetic construct]
GI:42794009 GenBank AHD77548.1 408 Sequence 23677 from patent US 8586006
GI:42794009 GenBank AIC48653.1 408 DPAGT1, partial [synthetic construct]

Related Sequences to LMP002444 proteins

Reference Database Accession Length Protein Name
GI:42794009 GenBank AAP36164.1 409 Homo sapiens dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), partial [synthetic construct]
GI:42794009 GenBank AAX29253.1 409 dolichyl-phosphate N-acetlyglucosamine phosphotransferase 1, partial [synthetic construct]
GI:42794009 GenBank AAX29254.1 409 dolichyl-phosphate N-acetlyglucosamine phosphotransferase 1, partial [synthetic construct]
GI:42794009 GenBank JAA03726.1 408 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) [Pan troglodytes]
GI:42794009 RefSeq XP_001165129.1 408 PREDICTED: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2 [Pan troglodytes]
GI:42794009 RefSeq XP_004052306.1 408 PREDICTED: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Gorilla gorilla gorilla]