Gene/Proteome Database (LMPD)

LMPD ID
LMP002465
Gene ID
83436
Species
Mus musculus (Mouse)
Gene Name
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Gene Symbol
Plekha2
Synonyms
6430512N22Rik; AI851530; AU041791; TAPP2; W91773
Alternate Names
pleckstrin homology domain-containing family A member 2; TAPP-2; PH domain-containing adaptor PHAD47; tandem PH domain-containing protein 2; PH domain-containing family A member 2; pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2andem PH Domain containing protein 2
Chromosome
8
Map Location
8 A2|8

Proteins

pleckstrin homology domain-containing family A member 2
Refseq ID NP_112547
Protein GI 13752587
UniProt ID Q9ERS5
mRNA ID NM_031257
Length 425
RefSeq Status VALIDATED
MPYVDRQNRICGFLDIEDNENSGKFLRRYFILDTQANCLLWYMDNPQNLAVGAGAVGSLQLTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDLKDWVEALNQASKITVPKAGTVPLATEVLKNLTAPPTLEKKPQVAYKTEIIGGVVVQTPISQNGGDGQEGCEPGTHAFLRRSQSYIPTSGCRPSTGPPLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIPLKDVLKTHECLVKSGDLLMRDNLFEIITTSRTFYVQADSPEDMHSWIEGIGAAVQALKCHPREPSFSRSISLTRPGSSTLTSAPNSILSRRRPPAEEKRGLCKAPSVASSWQPWTPVPQAEEKPLSVEHAPEDSLFMPNPGESTATGVLASSRVRHRSEPQHPKEKPFVFNLDDENIRTSDV

Gene Information

Entrez Gene ID
83436
Gene Name
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Gene Symbol
Plekha2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005545 IDA:MGI F 1-phosphatidylinositol binding
GO:0030165 IPI:UniProtKB F PDZ domain binding

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Protein Entry
PKHA2_MOUSE
UniProt ID
Q9ERS5
Species
Mouse

Comments

Comment Type Description
Function Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:12101241, ECO:0000269|PubMed:14516276}.
Interaction O75970:MPDZ (xeno); NbExp=5; IntAct=EBI-8079166, EBI-821405;
Similarity Contains 2 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:12101241}; Peripheral membrane protein {ECO:0000269|PubMed:12101241}. Nucleus {ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.
Subunit Binds MPDZ and PTPN13.

Identical and Related Proteins

Unique RefSeq proteins for LMP002465 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13752587 RefSeq NP_112547 425 pleckstrin homology domain-containing family A member 2

Identical Sequences to LMP002465 proteins

Reference Database Accession Length Protein Name
GI:13752587 GenBank EDL32843.1 425 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2, isoform CRA_c [Mus musculus]
GI:13752587 RefSeq XP_006509290.1 425 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X1 [Mus musculus]
GI:13752587 RefSeq XP_006509291.1 425 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X2 [Mus musculus]
GI:13752587 RefSeq XP_006509292.1 425 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X3 [Mus musculus]
GI:13752587 RefSeq XP_006509293.1 425 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X4 [Mus musculus]
GI:13752587 RefSeq XP_006509294.1 425 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X5 [Mus musculus]

Related Sequences to LMP002465 proteins

Reference Database Accession Length Protein Name
GI:13752587 GenBank EDL32841.1 431 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2, isoform CRA_a, partial [Mus musculus]
GI:13752587 GenBank EDM09049.1 426 rCG43087, isoform CRA_a [Rattus norvegicus]
GI:13752587 RefSeq XP_001071937.1 426 PREDICTED: pleckstrin homology domain-containing family A member 2 [Rattus norvegicus]
GI:13752587 RefSeq XP_003751669.1 425 PREDICTED: pleckstrin homology domain-containing family A member 2 [Rattus norvegicus]
GI:13752587 RefSeq XP_005066622.1 424 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X2 [Mesocricetus auratus]
GI:13752587 RefSeq XP_005066623.1 424 PREDICTED: pleckstrin homology domain-containing family A member 2 isoform X3 [Mesocricetus auratus]