Gene/Proteome Database (LMPD)

LMPD ID
LMP002469
Gene ID
7181
Species
Homo sapiens (Human)
Gene Name
nuclear receptor subfamily 2, group C, member 1
Gene Symbol
NR2C1
Synonyms
TR2
Chromosome
12
Map Location
12q22
Summary
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for NR2C1

Proteins

nuclear receptor subfamily 2 group C member 1 isoform a
Refseq ID NP_003288
Protein GI 189491739
UniProt ID P13056
mRNA ID NM_003297
Length 603
RefSeq Status REVIEWED
MATIEEIAHQIIEQQMGEIVTEQQTGQKIQIVTALDHNTQGKQFILTNHDGSTPSKVILARQDSTPGKVFLTTPDAAGVNQLFFTTPDLSAQHLQLLTDNSPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPSGVKTESAVLMTSDKAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIEKFQEKAYVEFQDYITKTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNIRIDSVIPHILKMEPADYNSQIIGHSI
nuclear receptor subfamily 2 group C member 1 isoform b
Refseq ID NP_001027458
Protein GI 73808084
UniProt ID P13056
mRNA ID NM_001032287
Length 467
RefSeq Status REVIEWED
MATIEEIAHQIIEQQMGEIVTEQQTGQKIQIVTALDHNTQGKQFILTNHDGSTPSKVILARQDSTPGKVFLTTPDAAGVNQLFFTTPDLSAQHLQLLTDNSPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPSGVKTESAVLMTSDKAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQAEG
nuclear receptor subfamily 2 group C member 1 isoform c
Refseq ID NP_001120834
Protein GI 189491766
UniProt ID P13056
mRNA ID NM_001127362
Length 483
RefSeq Status REVIEWED
MATIEEIAHQIIEQQMGEIVTEQQTGQKIQIVTALDHNTQGKQFILTNHDGSTPSKVILARQDSTPGKVFLTTPDAAGVNQLFFTTPDLSAQHLQLLTDNSPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPSGVKTESAVLMTSDKAESCQGDLSTLANVVTSLANLGKTKDLSQNSNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDAKVIAALIHFTRRAITDL

Gene Information

Entrez Gene ID
7181
Gene Name
nuclear receptor subfamily 2, group C, member 1
Gene Symbol
NR2C1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016605 IEA:Ensembl C PML body
GO:0005654 TAS:Reactome C nucleoplasm
GO:0003677 TAS:ProtInc F DNA binding
GO:0004872 TAS:ProtInc F receptor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0003707 TAS:ProtInc F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0010467 TAS:Reactome P gene expression
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0048386 IEA:Ensembl P positive regulation of retinoic acid receptor signaling pathway
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_12627 Generic Transcription Pathway
REACT_15525 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 2, group C, member 1
Protein Entry
NR2C1_HUMAN
UniProt ID
P13056
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=TR2-11; IsoId=P13056-1; Sequence=Displayed; Name=2; Synonyms=TR2-9; IsoId=P13056-2; Sequence=VSP_036855, VSP_036857; Name=3; Synonyms=TR2-7; IsoId=P13056-3; Sequence=VSP_036856, VSP_036858;
Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation.
Ptm Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).
Ptm Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO
Subunit Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA- binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002469 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189491739 RefSeq NP_003288 603 nuclear receptor subfamily 2 group C member 1 isoform a
73808084 RefSeq NP_001027458 467 nuclear receptor subfamily 2 group C member 1 isoform b
189491766 RefSeq NP_001120834 483 nuclear receptor subfamily 2 group C member 1 isoform c

Identical Sequences to LMP002469 proteins

Reference Database Accession Length Protein Name
GI:189491739 DBBJ BAJ20961.1 603 nuclear receptor subfamily 2, group C, member 1, partial [synthetic construct]
GI:189491766 GenBank AAA36650.1 483 steroid receptor TR2 [Homo sapiens]
GI:73808084 GenBank AAH40141.1 467 Nuclear receptor subfamily 2, group C, member 1 [Homo sapiens]
GI:189491766 GenBank EAW97517.1 483 nuclear receptor subfamily 2, group C, member 1, isoform CRA_a [Homo sapiens]
GI:73808084 GenBank EAW97518.1 467 nuclear receptor subfamily 2, group C, member 1, isoform CRA_b [Homo sapiens]
GI:189491739 GenBank EAW97519.1 603 nuclear receptor subfamily 2, group C, member 1, isoform CRA_c [Homo sapiens]
GI:73808084 GenBank ADZ15562.1 467 nuclear receptor subfamily 2, group C, member 1, partial [synthetic construct]
GI:189491766 GenBank AED82481.1 483 Sequence 1218 from patent US 7919467
GI:189491739 GenBank AFF59487.1 603 testicular nuclear receptor 2 variant 1 [Homo sapiens]
GI:73808084 GenBank AFF59488.1 467 testicular nuclear receptor 2 variant 2 [Homo sapiens]
GI:73808084 GenBank AHD77276.1 467 Sequence 22409 from patent US 8586006
GI:73808084 GenBank AIC49901.1 467 NR2C1, partial [synthetic construct]
GI:189491766 pat WO 483 Sequence 6 from Patent WO 8909223
GI:189491739 SwissProt P13056.2 603 RecName: Full=Nuclear receptor subfamily 2 group C member 1; AltName: Full=Orphan nuclear receptor TR2; AltName: Full=Testicular receptor 2 [Homo sapiens]

Related Sequences to LMP002469 proteins

Reference Database Accession Length Protein Name
GI:189491739 DBBJ BAF84008.1 603 unnamed protein product [Homo sapiens]
GI:73808084 DBBJ BAJ20961.1 603 nuclear receptor subfamily 2, group C, member 1, partial [synthetic construct]
GI:189491739 GenBank AAA36761.1 603 steroid receptor TR2-11 [Homo sapiens]
GI:73808084 GenBank EAW97517.1 483 nuclear receptor subfamily 2, group C, member 1, isoform CRA_a [Homo sapiens]
GI:189491766 GenBank EAW97519.1 603 nuclear receptor subfamily 2, group C, member 1, isoform CRA_c [Homo sapiens]
GI:73808084 GenBank EAW97519.1 603 nuclear receptor subfamily 2, group C, member 1, isoform CRA_c [Homo sapiens]
GI:189491766 GenBank ACM82761.1 484 Sequence 8259 from patent US 6812339
GI:189491739 GenBank ACM86169.1 604 Sequence 11667 from patent US 6812339
GI:189491739 GenBank AFE79919.1 604 nuclear receptor subfamily 2 group C member 1 isoform a [Macaca mulatta]
GI:189491766 GenBank AFF59487.1 603 testicular nuclear receptor 2 variant 1 [Homo sapiens]
GI:73808084 GenBank AFF59487.1 603 testicular nuclear receptor 2 variant 1 [Homo sapiens]
GI:189491739 GenBank AFH33825.1 604 nuclear receptor subfamily 2 group C member 1 isoform a [Macaca mulatta]
GI:189491739 GenBank AHD77277.1 603 Sequence 22410 from patent US 8586006
GI:73808084 RefSeq NP_003288.2 603 nuclear receptor subfamily 2 group C member 1 isoform a [Homo sapiens]
GI:189491766 RefSeq NP_003288.2 603 nuclear receptor subfamily 2 group C member 1 isoform a [Homo sapiens]
GI:189491766 RefSeq XP_002798778.1 483 PREDICTED: nuclear receptor subfamily 2 group C member 1-like isoform 2 [Macaca mulatta]
GI:189491766 RefSeq XP_008958595.1 484 PREDICTED: nuclear receptor subfamily 2 group C member 1 isoform X4 [Pan paniscus]
GI:73808084 SwissProt P13056.2 603 RecName: Full=Nuclear receptor subfamily 2 group C member 1; AltName: Full=Orphan nuclear receptor TR2; AltName: Full=Testicular receptor 2 [Homo sapiens]