Gene/Proteome Database (LMPD)

LMPD ID
LMP002477
Gene ID
18618
Species
Mus musculus (Mouse)
Gene Name
phosphatidylethanolamine N-methyltransferase
Gene Symbol
Pemt
Synonyms
PEAMT; PEMT2; Pempt; Pempt2
Alternate Names
phosphatidylethanolamine N-methyltransferase
Chromosome
11
Map Location
11 B1.3|11 37.81 cM
EC Number
2.1.1.17

Proteins

phosphatidylethanolamine N-methyltransferase isoform a
Refseq ID NP_001276940
Protein GI 585866350
UniProt ID Q61907
mRNA ID NM_001290011
Length 236
RefSeq Status VALIDATED
MEENTSPTTALISSSVAGHDCCGGFGNIDFRQADLFVMSWLLGYMDPTEPSFVAAVITIVFNPLFWNVVARWEQRTRKLSRAFGSPHLACYSLGICILLLNILRSHCFTQAMMSQPKMEGLDNHTTYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVAIVYVVALLYEEPFTAEIYRQKATRLHKRS
phosphatidylethanolamine N-methyltransferase isoform b
Refseq ID NP_032845
Protein GI 33667036
UniProt ID Q61907
mRNA ID NM_008819
Length 199
RefSeq Status VALIDATED
MSWLLGYMDPTEPSFVAAVITIVFNPLFWNVVARWEQRTRKLSRAFGSPHLACYSLGICILLLNILRSHCFTQAMMSQPKMEGLDNHTTYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVAIVYVVALLYEEPFTAEIYRQKATRLHKRS
phosphatidylethanolamine N-methyltransferase isoform b
Refseq ID NP_001276942
Protein GI 585866238
UniProt ID Q61907
mRNA ID NM_001290013
Length 199
RefSeq Status VALIDATED
Protein sequence is identical to GI:33667036 (mRNA isoform)
phosphatidylethanolamine N-methyltransferase isoform b
Refseq ID NP_001276941
Protein GI 586597942
UniProt ID Q61907
mRNA ID NM_001290012
Length 199
RefSeq Status VALIDATED
Protein sequence is identical to GI:33667036 (mRNA isoform)
phosphatidylethanolamine N-methyltransferase isoform c
Refseq ID NP_001276943
Protein GI 586597887
UniProt ID Q61907
mRNA ID NM_001290014
Length 113
RefSeq Status VALIDATED
MSWLLGYMDPTEPSFVAAVITIVFNPLFWNVVARWEQRTRKLSRAFGSPHLACYSLGICILLLNILRSHWHASPTGLLLTVLVAIVYVVALLYEEPFTAEIYRQKATRLHKRS

Gene Information

Entrez Gene ID
18618
Gene Name
phosphatidylethanolamine N-methyltransferase
Gene Symbol
Pemt
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:MGI C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005740 TAS:MGI C mitochondrial envelope
GO:0005739 IDA:MGI C mitochondrion
GO:0080101 IEA:UniProtKB-EC F phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO:0000773 IEA:UniProtKB-EC F phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0004608 ISS:MGI F phosphatidylethanolamine N-methyltransferase activity
GO:0006656 ISS:MGI P phosphatidylcholine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893602 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR024960 Phosphatidyl-N-methylethanolamine/N-methyltransferase
IPR007318 Phospholipid methyltransferase

UniProt Annotations

Entry Information

Gene Name
phosphatidylethanolamine N-methyltransferase
Protein Entry
PEMT_MOUSE
UniProt ID
Q61907
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61907-1; Sequence=Displayed; Name=2; IsoId=Q61907-2; Sequence=VSP_053224;
Catalytic Activity S-adenosyl-L-methionine + phosphatidyl-N- dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Catalytic Activity S-adenosyl-L-methionine + phosphatidyl-N- methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N- dimethylethanolamine. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Catalytic Activity S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. {ECO:0000255|PROSITE- ProRule:PRU00931}.
Function Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Sequence Caution Sequence=AAQ01190.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP002477 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
585866350 RefSeq NP_001276940 236 phosphatidylethanolamine N-methyltransferase isoform a
33667036 RefSeq NP_032845 199 phosphatidylethanolamine N-methyltransferase isoform b
586597887 RefSeq NP_001276943 113 phosphatidylethanolamine N-methyltransferase isoform c

Identical Sequences to LMP002477 proteins

Reference Database Accession Length Protein Name
GI:585866350 DBBJ BAE21818.1 236 unnamed protein product [Mus musculus]
GI:33667036 GenBank AAH26796.1 199 Phosphatidylethanolamine N-methyltransferase [Mus musculus]
GI:33667036 RefSeq NP_001276942.1 199 phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]
GI:33667036 RefSeq NP_001276941.1 199 phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]
GI:33667036 SwissProt Q61907.4 199 RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PEAMT; Short=PEMT; AltName: Full=PEMT2 [Mus musculus]

Related Sequences to LMP002477 proteins

Reference Database Accession Length Protein Name
GI:33667036 DBBJ BAE21818.1 236 unnamed protein product [Mus musculus]
GI:33667036 GenBank AAA67686.1 199 phosphatidylethanolamine-N-methyltransferase 2 [Mus musculus]
GI:586597887 GenBank AAA67686.1 199 phosphatidylethanolamine-N-methyltransferase 2 [Mus musculus]
GI:586597887 GenBank AAH26796.1 199 Phosphatidylethanolamine N-methyltransferase [Mus musculus]
GI:33667036 GenBank AAQ01190.1 203 phosphatidylethanolamine N-methyltransferase-like protein [Mus musculus]
GI:33667036 GenBank AAH91162.1 199 Phosphatidylethanolamine N-methyltransferase [Rattus norvegicus]
GI:586597887 RefSeq NP_032845.2 199 phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]
GI:585866350 RefSeq XP_005067741.1 225 PREDICTED: phosphatidylethanolamine N-methyltransferase isoform X1 [Mesocricetus auratus]
GI:585866350 RefSeq XP_005350014.1 225 PREDICTED: phosphatidylethanolamine N-methyltransferase isoform X1 [Microtus ochrogaster]
GI:586597887 RefSeq NP_001276942.1 199 phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]
GI:33667036 RefSeq NP_001276940.1 236 phosphatidylethanolamine N-methyltransferase isoform a [Mus musculus]
GI:585866350 RefSeq NP_001276941.1 199 phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]
GI:586597887 RefSeq NP_001276941.1 199 phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]
GI:585866350 RefSeq XP_006973678.1 225 PREDICTED: phosphatidylethanolamine N-methyltransferase isoform X1 [Peromyscus maniculatus bairdii]
GI:585866350 RefSeq XP_007642149.1 225 PREDICTED: phosphatidylethanolamine N-methyltransferase isoform X1 [Cricetulus griseus]
GI:33667036 SwissProt Q08388.2 199 RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PEAMT; Short=PEMT [Rattus norvegicus]
GI:586597887 SwissProt Q61907.4 199 RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PEAMT; Short=PEMT; AltName: Full=PEMT2 [Mus musculus]
GI:585866350 SwissProt Q61907.4 199 RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PEAMT; Short=PEMT; AltName: Full=PEMT2 [Mus musculus]