Gene/Proteome Database (LMPD)
Proteins
| mediator of RNA polymerase II transcription subunit 16 | |
|---|---|
| Refseq ID | NP_005472 |
| Protein GI | 38146094 |
| UniProt ID | Q9Y2X0 |
| mRNA ID | NM_005481 |
| Length | 877 |
| RefSeq Status | VALIDATED |
| MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016592 | IDA:UniProtKB | C | mediator complex |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | NAS:UniProtKB | C | nucleus |
| GO:0003824 | IEA:InterPro | F | catalytic activity |
| GO:0004872 | IDA:UniProtKB | F | receptor activity |
| GO:0046966 | IDA:UniProtKB | F | thyroid hormone receptor binding |
| GO:0030375 | IDA:UniProtKB | F | thyroid hormone receptor coactivator activity |
| GO:0003713 | TAS:ProtInc | F | transcription coactivator activity |
| GO:0003712 | IDA:UniProtKB | F | transcription cofactor activity |
| GO:0042809 | NAS:UniProtKB | F | vitamin D receptor binding |
| GO:0030521 | IDA:UniProtKB | P | androgen receptor signaling pathway |
| GO:0010467 | TAS:Reactome | P | gene expression |
| GO:0030518 | IDA:UniProtKB | P | intracellular steroid hormone receptor signaling pathway |
| GO:2000273 | IDA:GOC | P | positive regulation of receptor activity |
| GO:0045893 | IDA:UniProtKB | P | positive regulation of transcription, DNA-templated |
| GO:0006357 | NAS:UniProtKB | P | regulation of transcription from RNA polymerase II promoter |
| GO:0006366 | TAS:ProtInc | P | transcription from RNA polymerase II promoter |
| GO:0006367 | IDA:UniProtKB | P | transcription initiation from RNA polymerase II promoter |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04919 | Thyroid hormone signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_116145 | PPARA activates gene expression |
| REACT_19241 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| REACT_27161 | Transcriptional regulation of white adipocyte differentiation |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=5; Name=1 ; IsoId=Q9Y2X0-1; Sequence=Displayed; Name=2 ; IsoId=Q9Y2X0-2; Sequence=VSP_051724; Name=3 ; IsoId=Q9Y2X0-3; Sequence=VSP_051722, VSP_051724; Note=No experimental confirmation available. ; Name=4 ; IsoId=Q9Y2X0-4; Sequence=VSP_051721, VSP_051723; Note=No experimental confirmation available. ; Name=5; IsoId=Q9Y2X0-5; Sequence=VSP_028749, VSP_028750; Note=No experimental confirmation available.; |
| Caution | It is uncertain whether Met-1 or Met-13 is the initiator. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO |
| Sequence Caution | Sequence=AAD31087.1; Type=Frameshift; Positions=609; Evidence= ; |
| Similarity | Belongs to the Mediator complex subunit 16 family. |
| Similarity | Contains 5 WD repeats. {ECO |
| Subcellular Location | Nucleus . |
| Subunit | Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP002483 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 38146094 | RefSeq | NP_005472 | 877 | mediator of RNA polymerase II transcription subunit 16 |
Identical Sequences to LMP002483 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38146094 | RefSeq | XP_006722663.1 | 877 | PREDICTED: mediator of RNA polymerase II transcription subunit 16 isoform X1 [Homo sapiens] |
| GI:38146094 | SwissProt | Q9Y2X0.2 | 877 | RecName: Full=Mediator of RNA polymerase II transcription subunit 16; AltName: Full=Mediator complex subunit 16; AltName: Full=Thyroid hormone receptor-associated protein 5; AltName: Full=Thyroid hormone receptor-associated protein complex 95 kDa component; Short=Trap95; AltName: Full=Vitamin D3 receptor-interacting protein complex 92 kDa component; Short=DRIP92 [Homo sapiens] |
Related Sequences to LMP002483 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38146094 | GenBank | AAD30032.1 | 877 | thyroid hormone receptor-associated protein complex component TRAP95 [Homo sapiens] |
| GI:38146094 | GenBank | JAA06428.1 | 877 | mediator complex subunit 16 [Pan troglodytes] |
| GI:38146094 | GenBank | JAA12299.1 | 877 | mediator complex subunit 16 [Pan troglodytes] |
| GI:38146094 | GenBank | JAA32849.1 | 877 | mediator complex subunit 16 [Pan troglodytes] |
| GI:38146094 | GenBank | JAA41748.1 | 877 | mediator complex subunit 16 [Pan troglodytes] |
| GI:38146094 | RefSeq | XP_009191264.1 | 877 | PREDICTED: mediator of RNA polymerase II transcription subunit 16 isoform X3 [Papio anubis] |