Gene/Proteome Database (LMPD)

LMPD ID
LMP002484
Gene ID
51100
Species
Homo sapiens (Human)
Gene Name
SH3-domain GRB2-like endophilin B1
Gene Symbol
SH3GLB1
Synonyms
Bif-1; PPP1R70; dJ612B15.2
Alternate Names
endophilin-B1; Bax-interacting factor 1; SH3-containing protein SH3GLB1; SH3 domain-containing GRB2-like protein B1; protein phosphatase 1, regulatory subunit 70
Chromosome
1
Map Location
1p22
Summary
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Orthologs
View orthologs and multiple alignments for SH3GLB1

Proteins

endophilin-B1 isoform 1
Refseq ID NP_057093
Protein GI 7705773
UniProt ID Q9Y371
mRNA ID NM_016009
Length 365
RefSeq Status REVIEWED
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
endophilin-B1 isoform 2
Refseq ID NP_001193580
Protein GI 331284170
UniProt ID Q9Y371
mRNA ID NM_001206651
Length 394
RefSeq Status REVIEWED
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSARLEGDNIMVNFSYMLNFLHVKWLKSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
endophilin-B1 isoform 3
Refseq ID NP_001193581
Protein GI 331284172
UniProt ID Q9Y371
mRNA ID NM_001206652
Length 386
RefSeq Status REVIEWED
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSARLEGDNIMIWAEEVTKSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
endophilin-B1 isoform 4
Refseq ID NP_001193582
Protein GI 331284174
UniProt ID Q9Y371
mRNA ID NM_001206653
Length 265
RefSeq Status REVIEWED
MIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN

Gene Information

Entrez Gene ID
51100
Gene Name
SH3-domain GRB2-like endophilin B1
Gene Symbol
SH3GLB1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005737 IDA:HGNC C cytoplasm
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0043234 IEA:Ensembl C protein complex
GO:0005504 IEA:Ensembl F fatty acid binding
GO:0042802 IPI:IntAct F identical protein binding
GO:0042171 IEA:Ensembl F lysophosphatidic acid acyltransferase activity
GO:0042803 IPI:HGNC F protein homodimerization activity
GO:0051084 IEA:Ensembl P 'de novo' posttranslational protein folding
GO:0006915 IEA:UniProtKB-KW P apoptotic process
GO:0006654 IEA:Ensembl P phosphatidic acid biosynthetic process
GO:1900740 IEA:Ensembl P positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461 IDA:UniProtKB P positive regulation of protein oligomerization
GO:0051259 IDA:UniProtKB P protein oligomerization

KEGG Pathway Links

KEGG Pathway ID Description
hsa04144 Endocytosis
ko04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR027267 Arfaptin homology (AH) domain/BAR domain
IPR004148 BAR domain
IPR028503 Endophilin-B1
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
SH3-domain GRB2-like endophilin B1
Protein Entry
SHLB1_HUMAN
UniProt ID
Q9Y371
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Y371-1; Sequence=Displayed; Name=2; IsoId=Q9Y371-2; Sequence=VSP_009276; Name=3; IsoId=Q9Y371-3; Sequence=VSP_044895; Note=No experimental confirmation available.;
Caution It is uncertain whether Met-1 or Met-4 is the initiator.
Caution Was originally thought to have lysophosphatidic acid acyltransferase activity, but by homology with SH3GL2/endophilin A1 is unlikely to have this activity.
Domain An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
Function May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. {ECO
Interaction Self; NbExp=4; IntAct=EBI-2623095, EBI-2623095; Q07812:BAX; NbExp=2; IntAct=EBI-5291808, EBI-516580; P24522:GADD45A; NbExp=2; IntAct=EBI-2623095, EBI-448167; Q9NR46:SH3GLB2; NbExp=5; IntAct=EBI-2623095, EBI-749607; Q9P2Y5:UVRAG; NbExp=2; IntAct=EBI-2623095, EBI-2952704;
Miscellaneous HeLa cells lacking SH3GLB1 show dissociation of outer and inner mitochondrial membrane as well as abnormal mitochondrial morphology. Cells overexpressing SH3GLB1 lacking an N-terminal amphipathic helix show a similar phenotype.
Miscellaneous SH3GLB1 binds liposomes and induces formation of tubules from liposomes. SH3GLB1 lacking the N-terminal amphipathic helix fails to induce liposome tubulation.
Ptm Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.
Sequence Caution Sequence=AAF81225.1; Type=Erroneous initiation; Evidence= ; Sequence=BAD88797.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the endophilin family.
Similarity Contains 1 BAR domain. {ECO
Similarity Contains 1 SH3 domain. {ECO
Subcellular Location Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane ; Peripheral membrane protein . Note=Association with the Golgi apparatus depends on the cell type.
Subunit Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity). Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding.
Tissue Specificity Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002484 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7705773 RefSeq NP_057093 365 endophilin-B1 isoform 1
331284170 RefSeq NP_001193580 394 endophilin-B1 isoform 2
331284172 RefSeq NP_001193581 386 endophilin-B1 isoform 3
331284174 RefSeq NP_001193582 265 endophilin-B1 isoform 4

Identical Sequences to LMP002484 proteins

Reference Database Accession Length Protein Name
GI:331284174 DBBJ BAG64694.1 265 unnamed protein product [Homo sapiens]
GI:331284172 GenBank AAF73017.1 386 endophilin B1 [Homo sapiens]
GI:331284172 GenBank EAW73182.1 386 SH3-domain GRB2-like endophilin B1, isoform CRA_b [Homo sapiens]
GI:7705773 GenBank JAA21968.1 365 SH3-domain GRB2-like endophilin B1 [Pan troglodytes]
GI:7705773 GenBank JAA21969.1 365 SH3-domain GRB2-like endophilin B1 [Pan troglodytes]
GI:7705773 GenBank JAA21970.1 365 SH3-domain GRB2-like endophilin B1 [Pan troglodytes]
GI:7705773 GenBank JAA41332.1 365 SH3-domain GRB2-like endophilin B1 [Pan troglodytes]
GI:7705773 GenBank JAA41333.1 365 SH3-domain GRB2-like endophilin B1 [Pan troglodytes]
GI:7705773 GenBank AIC51395.1 365 SH3GLB1, partial [synthetic construct]
GI:331284172 RefSeq XP_003805353.1 386 PREDICTED: endophilin-B1 isoform X3 [Pan paniscus]
GI:331284170 RefSeq XP_003805354.1 394 PREDICTED: endophilin-B1 isoform X2 [Pan paniscus]

Related Sequences to LMP002484 proteins

Reference Database Accession Length Protein Name
GI:331284174 DBBJ BAA91999.1 365 unnamed protein product [Homo sapiens]
GI:7705773 DBBJ BAD88797.1 391 KIAA0491, partial [Homo sapiens]
GI:331284174 EMBL CAE89919.1 365 unnamed protein product [Homo sapiens]
GI:331284174 GenBank ABM83955.1 365 SH3-domain GRB2-like endophilin B1 [synthetic construct]
GI:331284174 GenBank ABM87272.1 365 SH3-domain GRB2-like endophilin B1, partial [synthetic construct]
GI:331284172 GenBank EHH14924.1 386 hypothetical protein EGK_00934 [Macaca mulatta]
GI:331284172 GenBank EHH50056.1 386 hypothetical protein EGM_00819 [Macaca fascicularis]
GI:7705773 GenBank AFE64355.1 365 endophilin-B1 isoform 1 [Macaca mulatta]
GI:7705773 GenBank AFE64356.1 365 endophilin-B1 isoform 1 [Macaca mulatta]
GI:7705773 GenBank AFE64357.1 365 endophilin-B1 isoform 1 [Macaca mulatta]
GI:331284174 RefSeq NP_057093.1 365 endophilin-B1 isoform 1 [Homo sapiens]
GI:331284174 RefSeq XP_003805352.1 365 PREDICTED: endophilin-B1 isoform X4 [Pan paniscus]
GI:7705773 RefSeq XP_004026131.1 365 PREDICTED: endophilin-B1 [Gorilla gorilla gorilla]
GI:331284172 RefSeq XP_004026132.1 386 PREDICTED: endophilin-B1 [Gorilla gorilla gorilla]
GI:331284170 RefSeq XP_004026133.1 394 PREDICTED: endophilin-B1 [Gorilla gorilla gorilla]
GI:331284170 RefSeq XP_005542872.1 402 PREDICTED: endophilin-B1 isoform X1 [Macaca fascicularis]
GI:331284170 RefSeq XP_005542873.1 394 PREDICTED: endophilin-B1 isoform X2 [Macaca fascicularis]
GI:331284172 RefSeq XP_005542874.1 386 PREDICTED: endophilin-B1 isoform X3 [Macaca fascicularis]
GI:331284170 RefSeq XP_006710735.1 402 PREDICTED: endophilin-B1 isoform X1 [Homo sapiens]
GI:331284170 RefSeq XP_007976257.1 402 PREDICTED: endophilin-B1 isoform X1 [Chlorocebus sabaeus]
GI:331284172 RefSeq XP_007976258.1 386 PREDICTED: endophilin-B1 isoform X2 [Chlorocebus sabaeus]
GI:7705773 RefSeq XP_007976260.1 365 PREDICTED: endophilin-B1 isoform X4 [Chlorocebus sabaeus]
GI:331284170 RefSeq XP_008967895.1 402 PREDICTED: endophilin-B1 isoform X1 [Pan paniscus]
GI:331284172 RefSeq XP_003892198.2 386 PREDICTED: LOW QUALITY PROTEIN: endophilin-B1 [Papio anubis]