Gene/Proteome Database (LMPD)

LMPD ID
LMP002489
Gene ID
114882
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 8
Gene Symbol
OSBPL8
Synonyms
MST120; MSTP120; ORP8; OSBP10
Chromosome
12
Map Location
12q14
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for OSBPL8

Proteins

oxysterol-binding protein-related protein 8 isoform a
Refseq ID NP_065892
Protein GI 18079218
UniProt ID Q9BZF1
mRNA ID NM_020841
Length 889
RefSeq Status REVIEWED
MEGGLADGEPDRTSLLGDSKDVLGPSTVVANSDESQLLTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVAKGYSSPEPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPATDYFLQQKDYFIIFLLILLQVIINFMFK
oxysterol-binding protein-related protein 8 isoform b
Refseq ID NP_001003712
Protein GI 51243032
UniProt ID Q5HYM3
mRNA ID NM_001003712
Length 847
RefSeq Status REVIEWED
MSQRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVAKGYSSPEPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPATDYFLQQKDYFIIFLLILLQVIINFMFK

Gene Information

Entrez Gene ID
114882
Gene Name
oxysterol binding protein-like 8
Gene Symbol
OSBPL8
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein-like 8
Protein Entry
OSBL8_HUMAN
UniProt ID
Q9BZF1
Species
Human

Comments

Comment Type Description
Similarity Belongs to the OSBP family.
Similarity Contains 1 PH domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP002489 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18079218 RefSeq NP_065892 889 oxysterol-binding protein-related protein 8 isoform a
51243032 RefSeq NP_001003712 847 oxysterol-binding protein-related protein 8 isoform b

Identical Sequences to LMP002489 proteins

Reference Database Accession Length Protein Name
GI:18079218 GenBank JAA30170.1 889 oxysterol binding protein-like 8 [Pan troglodytes]
GI:18079218 GenBank JAA43575.1 889 oxysterol binding protein-like 8 [Pan troglodytes]
GI:51243032 GenBank AHD74099.1 847 Sequence 13019 from patent US 8586006
GI:18079218 GenBank AHD74100.1 889 Sequence 13020 from patent US 8586006
GI:18079218 GenBank AIC52852.1 889 OSBPL8, partial [synthetic construct]
GI:18079218 RefSeq XP_004053645.1 889 PREDICTED: oxysterol-binding protein-related protein 8 isoform 1 [Gorilla gorilla gorilla]
GI:51243032 RefSeq XP_004053646.1 847 PREDICTED: oxysterol-binding protein-related protein 8 isoform 2 [Gorilla gorilla gorilla]
GI:18079218 RefSeq XP_005268678.1 889 PREDICTED: oxysterol-binding protein-related protein 8 isoform X1 [Homo sapiens]
GI:51243032 RefSeq XP_005268680.1 847 PREDICTED: oxysterol-binding protein-related protein 8 isoform X3 [Homo sapiens]
GI:51243032 RefSeq XP_006719287.1 847 PREDICTED: oxysterol-binding protein-related protein 8 isoform X6 [Homo sapiens]
GI:51243032 RefSeq XP_008956603.1 847 PREDICTED: oxysterol-binding protein-related protein 8 isoform X3 [Pan paniscus]
GI:51243032 RefSeq XP_009424153.1 847 PREDICTED: oxysterol-binding protein-related protein 8 isoform X4 [Pan troglodytes]

Related Sequences to LMP002489 proteins

Reference Database Accession Length Protein Name
GI:18079218 DBBJ BAA95975.3 939 KIAA1451 protein, partial [Homo sapiens]
GI:51243032 GenBank AAI11729.1 889 Oxysterol-binding protein-like protein 8, isoform a [Homo sapiens]
GI:51243032 GenBank AED82484.1 889 Sequence 1221 from patent US 7919467
GI:18079218 GenBank EHH20985.1 889 Oxysterol-binding protein-related protein 8 [Macaca mulatta]
GI:18079218 GenBank EHH66511.1 889 Oxysterol-binding protein-related protein 8 [Macaca fascicularis]
GI:51243032 GenBank AIC52852.1 889 OSBPL8, partial [synthetic construct]
GI:51243032 RefSeq NP_065892.1 889 oxysterol-binding protein-related protein 8 isoform a [Homo sapiens]
GI:18079218 RefSeq NP_001247808.1 889 oxysterol-binding protein-related protein 8 [Macaca mulatta]
GI:51243032 RefSeq XP_004053645.1 889 PREDICTED: oxysterol-binding protein-related protein 8 isoform 1 [Gorilla gorilla gorilla]
GI:18079218 RefSeq XP_005571652.1 889 PREDICTED: oxysterol-binding protein-related protein 8 isoform X3 [Macaca fascicularis]
GI:18079218 RefSeq XP_006719285.1 912 PREDICTED: oxysterol-binding protein-related protein 8 isoform X4 [Homo sapiens]
GI:51243032 SwissProt Q9BZF1.3 889 RecName: Full=Oxysterol-binding protein-related protein 8; Short=ORP-8; Short=OSBP-related protein 8 [Homo sapiens]