Gene/Proteome Database (LMPD)
LMPD ID
LMP002490
Gene ID
Species
Mus musculus (Mouse)
Gene Name
fucosyltransferase 2
Gene Symbol
Synonyms
-
Chromosome
7
Map Location
7 B4|7 29.41 cM
Summary
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Orthologs
Proteins
| galactoside 2-alpha-L-fucosyltransferase 2 | |
|---|---|
| Refseq ID | NP_061364 |
| Protein GI | 31542827 |
| UniProt ID | Q9JL27 |
| mRNA ID | NM_018876 |
| Length | 347 |
| RefSeq Status | REVIEWED |
| MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH | |
| galactoside 2-alpha-L-fucosyltransferase 2 | |
|---|---|
| Refseq ID | NP_001258922 |
| Protein GI | 431822426 |
| UniProt ID | Q9JL27 |
| mRNA ID | NM_001271993 |
| Length | 347 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:31542827 (mRNA isoform) | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0016020 | IEA:InterPro | C | membrane |
| GO:0008417 | IDA:MGI | F | fucosyltransferase activity |
| GO:0008107 | IDA:MGI | F | galactoside 2-alpha-L-fucosyltransferase activity |
| GO:0036065 | IDA:GOC | P | fucosylation |
| GO:0006486 | IDA:MGI | P | protein glycosylation |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002516 | Glycosyl transferase, family 11 |
UniProt Annotations
Entry Information
Identical and Related Proteins
Unique RefSeq proteins for LMP002490 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31542827 | RefSeq | NP_061364 | 347 | galactoside 2-alpha-L-fucosyltransferase 2 |
Identical Sequences to LMP002490 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31542827 | GenBank | EDL22881.1 | 347 | mCG23184, partial [Mus musculus] |
| GI:31542827 | GenBank | AAI45832.1 | 347 | Fucosyltransferase 2 [Mus musculus] |
| GI:31542827 | GenBank | AAI38535.1 | 347 | Fucosyltransferase 2 [Mus musculus] |
| GI:31542827 | RefSeq | NP_001258922.1 | 347 | galactoside 2-alpha-L-fucosyltransferase 2 [Mus musculus] |
| GI:31542827 | RefSeq | XP_006540680.1 | 347 | PREDICTED: galactoside 2-alpha-L-fucosyltransferase 2 isoform X1 [Mus musculus] |
| GI:31542827 | SwissProt | Q9JL27.1 | 347 | RecName: Full=Galactoside 2-alpha-L-fucosyltransferase 2; AltName: Full=Alpha(1,2)FT 2; AltName: Full=Fucosyltransferase 2; AltName: Full=GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; AltName: Full=Secretory blood group protein 2 [Mus musculus] |
Related Sequences to LMP002490 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31542827 | DBBJ | BAB68639.1 | 321 | GDP-L-fucose:beta-D-galactoside 2-alpha-1-fucosyltransferase, partial [Mus musculus brevirostris] |
| GI:31542827 | DBBJ | BAB68640.1 | 321 | GDP-L-fucose:beta-D-galactoside 2-alpha-1-fucosyltransferase, partial [Mus musculus musculus] |
| GI:31542827 | DBBJ | BAB68641.1 | 321 | GDP-L-fucose:beta-D-galactoside 2-alpha-1-fucosyltransferase, partial [Mus musculus castaneus] |
| GI:31542827 | DBBJ | BAB68642.1 | 321 | GDP-L-fucose:beta-D-galactoside 2-alpha-1-fucosyltransferase, partial [Mus musculus molossinus] |
| GI:31542827 | DBBJ | BAB68643.1 | 321 | GDP-L-fucose:beta-D-galactoside 2-alpha-1-fucosyltransferase, partial [Mus musculus domesticus] |
| GI:31542827 | GenBank | AAC16887.1 | 347 | GDP-L-fucose:beta-D-galactoside 2-alpha-1-fucosyltransferase [Mus musculus] |