Gene/Proteome Database (LMPD)
LMPD ID
LMP002493
Gene ID
Species
Homo sapiens (Human)
Gene Name
synaptojanin 2
Gene Symbol
Synonyms
INPP5H
Chromosome
6
Map Location
6q25.3
Summary
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Orthologs
Proteins
| synaptojanin-2 isoform 1 | |
|---|---|
| Refseq ID | NP_003889 |
| Protein GI | 26190608 |
| UniProt ID | O15056 |
| mRNA ID | NM_003898 |
| Length | 1496 |
| RefSeq Status | REVIEWED |
| MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042578 | IEA:InterPro | F | phosphoric ester hydrolase activity |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| PWY-6364 | D-myo-inositol (1,3,4)-trisphosphate biosynthesis |
| PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002013 | SAC domain |
UniProt Annotations
Entry Information
Identical and Related Proteins
Unique RefSeq proteins for LMP002493 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 26190608 | RefSeq | NP_003889 | 1496 | synaptojanin-2 isoform 1 |
Identical Sequences to LMP002493 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:26190608 | DBBJ | BAG10321.1 | 1496 | synaptojanin-2, partial [synthetic construct] |
| GI:26190608 | EMBL | CAR81445.1 | 1496 | unnamed protein product [Homo sapiens] |
| GI:26190608 | EMBL | CBX84907.1 | 1496 | unnamed protein product [Homo sapiens] |
| GI:26190608 | GenBank | EAW47665.1 | 1496 | synaptojanin 2, isoform CRA_a [Homo sapiens] |
| GI:26190608 | GenBank | ADS18187.1 | 1496 | Sequence 44 from patent US 7763418 |
| GI:26190608 | GenBank | AHD76430.1 | 1496 | Sequence 19703 from patent US 8586006 |
Related Sequences to LMP002493 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:26190608 | GenBank | JAA01336.1 | 1496 | synaptojanin 2 [Pan troglodytes] |
| GI:26190608 | GenBank | JAA16165.1 | 1496 | synaptojanin 2 [Pan troglodytes] |
| GI:26190608 | GenBank | JAA27951.1 | 1496 | synaptojanin 2 [Pan troglodytes] |
| GI:26190608 | GenBank | JAA43385.1 | 1496 | synaptojanin 2 [Pan troglodytes] |
| GI:26190608 | RefSeq | XP_004044926.1 | 1496 | PREDICTED: synaptojanin-2 [Gorilla gorilla gorilla] |
| GI:26190608 | RefSeq | XP_006715654.1 | 1495 | PREDICTED: synaptojanin-2 isoform X7 [Homo sapiens] |