Gene/Proteome Database (LMPD)

LMPD ID
LMP002501
Gene ID
8705
Species
Homo sapiens (Human)
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Gene Symbol
B3GALT4
Synonyms
BETA3GALT4; GALT2; GALT4
Chromosome
6
Map Location
6p21.3
Summary
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for B3GALT4

Proteins

beta-1,3-galactosyltransferase 4
Refseq ID NP_003773
Protein GI 4502341
UniProt ID Q5STJ7
mRNA ID NM_003782
Length 378
RefSeq Status REVIEWED
MQLRLFRRLLLAALLLVIVWTLFGPSGLGEELLSLSLASLLPAPASPGPPLALPRLLIPNQEACSGPGAPPFLLILVCTAPENLNQRNAIRASWGGLREARGLRVQTLFLLGEPNAQHPVWGSQGSDLASESAAQGDILQAAFQDSYRNLTLKTLSGLNWAEKHCPMARYVLKTDDDVYVNVPELVSELVLRGGRWGQWERSTEPQREAEQEGGQVLHSEEVPLLYLGRVHWRVNPSRTPGGRHRVSEEQWPHTWGPFPPYASGTGYVLSASAVQLILKVASRAPLLPLEDVFVGVSARRGGLAPTQCVKLAGATHYPLDRCCYGKFLLTSHRLDPWKMQEAWKLVGGSDGERTAPFCSWFQGVLGILRCRAIAWLQS

Gene Information

Entrez Gene ID
8705
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Gene Symbol
B3GALT4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008378 IEA:InterPro F galactosyltransferase activity
GO:0006486 IEA:InterPro P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00604 Glycosphingolipid biosynthesis - ganglio series
hsa01100 Metabolic pathways
hsa00514 Other types of O-glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Protein Entry
B3GT4_HUMAN
UniProt ID
Q5STJ7
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002501 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4502341 RefSeq NP_003773 378 beta-1,3-galactosyltransferase 4

Identical Sequences to LMP002501 proteins

Reference Database Accession Length Protein Name
GI:4502341 GenBank JAA20894.1 378 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [Pan troglodytes]
GI:4502341 GenBank JAA31521.1 378 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [Pan troglodytes]
GI:4502341 GenBank JAA33753.1 378 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [Pan troglodytes]
GI:4502341 GenBank AIC50184.1 378 B3GALT4, partial [synthetic construct]
GI:4502341 RefSeq XP_008958902.1 378 PREDICTED: beta-1,3-galactosyltransferase 4 [Pan paniscus]
GI:4502341 RefSeq XP_009449282.1 378 PREDICTED: beta-1,3-galactosyltransferase 4 [Pan troglodytes]

Related Sequences to LMP002501 proteins

Reference Database Accession Length Protein Name
GI:4502341 DBBJ BAG52107.1 378 unnamed protein product [Homo sapiens]
GI:4502341 EMBL CAF86923.1 378 unnamed protein product [Homo sapiens]
GI:4502341 GenBank ACC03086.1 378 Sequence 13 from patent US 7332279
GI:4502341 GenBank ACD99695.1 624 N-EGFP/UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase polypeptide 4 fusion protein [synthetic construct]
GI:4502341 GenBank ACM86069.1 393 Sequence 11567 from patent US 6812339
GI:4502341 GenBank ACM99942.1 378 Sequence 13 from patent US 7476527