Gene/Proteome Database (LMPD)

LMPD ID
LMP002504
Gene ID
7368
Species
Homo sapiens (Human)
Gene Name
UDP glycosyltransferase 8
Gene Symbol
UGT8
Synonyms
CGT; UGT4
Alternate Names
2-hydroxyacylsphingosine 1-beta-galactosyltransferase; cerebroside synthase; ceramide UDP-galactosyltransferase; uridine diphosphate glycosyltransferase 8; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase
Chromosome
4
Map Location
4q26
EC Number
2.4.1.45
Summary
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Orthologs
View orthologs and multiple alignments for UGT8

Proteins

2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor
Refseq ID NP_001121646
Protein GI 189491660
UniProt ID Q16880
mRNA ID NM_001128174
Length 541
RefSeq Status VALIDATED
MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor
Refseq ID NP_003351
Protein GI 40254471
UniProt ID Q16880
mRNA ID NM_003360
Length 541
RefSeq Status VALIDATED
Protein sequence is identical to GI:189491660 (mRNA isoform)
sig_peptide: 1..20 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2) calculated_mol_wt: 2260 peptide sequence: MKSYTPYFILLWSAVGIAKA mat_peptide: 21..541 product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q16880.2) calculated_mol_wt: 59214 peptide sequence: AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK sig_peptide: 1..20 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q16880.2) calculated_mol_wt: 2260 peptide sequence: MKSYTPYFILLWSAVGIAKA mat_peptide: 21..541 product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q16880.2) calculated_mol_wt: 59214 peptide sequence: AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK

Gene Information

Entrez Gene ID
7368
Gene Name
UDP glycosyltransferase 8
Gene Symbol
UGT8
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003851 IEA:UniProtKB-EC F 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0008489 TAS:ProtInc F UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0008088 IEA:Ensembl P axon cargo transport
GO:0007417 TAS:ProtInc P central nervous system development
GO:0007010 IEA:Ensembl P cytoskeleton organization
GO:0006682 IEA:UniProtKB-UniPathway P galactosylceramide biosynthetic process
GO:0048812 IEA:Ensembl P neuron projection morphogenesis
GO:0030913 IEA:Ensembl P paranodal junction assembly
GO:0007422 TAS:ProtInc P peripheral nervous system development
GO:0002175 IEA:Ensembl P protein localization to paranode region of axon

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00600 Sphingolipid metabolism
ko00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP glycosyltransferase 8
Protein Entry
CGT_HUMAN
UniProt ID
Q16880
Species
Human

Comments

Comment Type Description
Catalytic Activity UDP-alpha-D-galactose + 2-(2- hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2- hydroxyacyl)sphingosine.
Function Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
Pathway Sphingolipid metabolism; galactosylceramide biosynthesis.
Similarity Belongs to the UDP-glycosyltransferase family.
Subcellular Location Membrane ; Single-pass membrane protein .
Web Resource Name=Functional Glycomics Gateway - GTase; Note=2- hydroxyacylsphingosine 1-beta-galactosyltransferase precursor; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_449";

Identical and Related Proteins

Unique RefSeq proteins for LMP002504 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189491660 RefSeq NP_001121646 541 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

Identical Sequences to LMP002504 proteins

Reference Database Accession Length Protein Name
GI:189491660 DBBJ BAG54609.1 541 unnamed protein product [Homo sapiens]
GI:189491660 GenBank AAC50565.1 541 UDP-Galactose ceramide galactosyl transferase [Homo sapiens]
GI:189491660 GenBank AAH75069.1 541 UGT8 protein [Homo sapiens]
GI:189491660 GenBank EAX06307.1 541 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase) [Homo sapiens]
GI:189491660 GenBank AHD72360.1 541 Sequence 7858 from patent US 8586006
GI:189491660 RefSeq NP_003351.2 541 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor [Homo sapiens]

Related Sequences to LMP002504 proteins

Reference Database Accession Length Protein Name
GI:189491660 RefSeq XP_001146803.1 541 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [Pan troglodytes]
GI:189491660 RefSeq XP_006714365.1 541 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1 [Homo sapiens]
GI:189491660 RefSeq XP_006714366.1 541 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X2 [Homo sapiens]
GI:189491660 RefSeq XP_008953675.1 541 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [Pan paniscus]
GI:189491660 RefSeq XP_009446453.1 541 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [Pan troglodytes]
GI:189491660 SwissProt Q16880.2 541 RecName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase; AltName: Full=Ceramide UDP-galactosyltransferase; AltName: Full=Cerebroside synthase; AltName: Full=UDP-galactose-ceramide galactosyltransferase; Flags: Precursor [Homo sapiens]