Gene/Proteome Database (LMPD)

LMPD ID
LMP002513
Gene ID
53637
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate receptor 5
Gene Symbol
S1PR5
Synonyms
EDG8; Edg-8; S1P5; SPPR-1; SPPR-2
Alternate Names
sphingosine 1-phosphate receptor 5; S1P receptor 5; S1P receptor Edg-8; sphingosine 1-phosphate receptor EDG8; sphingosine 1-phosphate receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
Chromosome
19
Map Location
19p13.2
Summary
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for S1PR5

Proteins

sphingosine 1-phosphate receptor 5
Refseq ID NP_110387
Protein GI 13540517
UniProt ID Q9H228
mRNA ID NM_030760
Length 398
RefSeq Status VALIDATED
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
sphingosine 1-phosphate receptor 5
Refseq ID NP_001159687
Protein GI 261278306
UniProt ID Q9H228
mRNA ID NM_001166215
Length 398
RefSeq Status VALIDATED
Protein sequence is identical to GI:13540517 (mRNA isoform)

Gene Information

Entrez Gene ID
53637
Gene Name
sphingosine-1-phosphate receptor 5
Gene Symbol
S1PR5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0045664 IEA:Ensembl P regulation of neuron differentiation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19231 G alpha (i) signalling events
REACT_21340 GPCR ligand binding
REACT_18365 Lysosphingolipid and LPA receptors

Domain Information

InterPro Annotations

Accession Description
IPR005386 EDG-8 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 5
Protein Entry
S1PR5_HUMAN
UniProt ID
Q9H228
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H228-1; Sequence=Displayed; Name=2; IsoId=Q9H228-2; Sequence=VSP_013369, VSP_013370;
Developmental Stage At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found.
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002513 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13540517 RefSeq NP_110387 398 sphingosine 1-phosphate receptor 5

Identical Sequences to LMP002513 proteins

Reference Database Accession Length Protein Name
GI:13540517 GenBank AEJ73536.1 398 Sequence 16 from patent US 7964358
GI:13540517 GenBank AEJ73537.1 398 Sequence 17 from patent US 7964358
GI:13540517 GenBank JAA01783.1 398 sphingosine-1-phosphate receptor 5 [Pan troglodytes]
GI:13540517 GenBank AHD76190.1 398 Sequence 19463 from patent US 8586006
GI:13540517 GenBank AIC56511.1 398 S1PR5, partial [synthetic construct]
GI:13540517 RefSeq XP_004060049.1 398 PREDICTED: sphingosine 1-phosphate receptor 5 isoform 2 [Gorilla gorilla gorilla]

Related Sequences to LMP002513 proteins

Reference Database Accession Length Protein Name
GI:13540517 GenBank EAW84113.1 500 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, isoform CRA_a [Homo sapiens]
GI:13540517 GenBank ABM82216.1 398 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 [synthetic construct]
GI:13540517 GenBank AED52623.1 500 Sequence 30 from patent US 7893235
GI:13540517 RefSeq XP_004060048.1 500 PREDICTED: sphingosine 1-phosphate receptor 5 isoform 1 [Gorilla gorilla gorilla]
GI:13540517 RefSeq XP_004060050.1 619 PREDICTED: sphingosine 1-phosphate receptor 5 isoform 3 [Gorilla gorilla gorilla]
GI:13540517 RefSeq XP_005259994.1 500 PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Homo sapiens]