Gene/Proteome Database (LMPD)

LMPD ID
LMP002516
Gene ID
55750
Species
Homo sapiens (Human)
Gene Name
acylglycerol kinase
Gene Symbol
AGK
Synonyms
CATC5; CTRCT38; MTDPS10; MULK
Chromosome
7
Map Location
7q34
Summary
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]
Orthologs
View orthologs and multiple alignments for AGK

Proteins

acylglycerol kinase, mitochondrial precursor
Refseq ID NP_060708
Protein GI 8922701
UniProt ID Q53H12
mRNA ID NM_018238
Length 422
RefSeq Status REVIEWED
MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ
transit_peptide: 1..31 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q53H12.2) calculated_mol_wt: 3667 peptide sequence: MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYG mat_peptide: 32..422 product: Acylglycerol kinase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q53H12.2) calculated_mol_wt: 43488 peptide sequence: KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ

Gene Information

Entrez Gene ID
55750
Gene Name
acylglycerol kinase
Gene Symbol
AGK
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0016020 IEA:Ensembl C membrane
GO:0005739 IDA:HPA C mitochondrion
GO:0001729 IEA:Ensembl F ceramide kinase activity
GO:0004143 IEA:InterPro F diacylglycerol kinase activity
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
ko00561 Glycerolipid metabolism
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
acylglycerol kinase
Protein Entry
AGK_HUMAN
UniProt ID
Q53H12
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002516 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8922701 RefSeq NP_060708 422 acylglycerol kinase, mitochondrial precursor

Identical Sequences to LMP002516 proteins

Reference Database Accession Length Protein Name
GI:8922701 GenBank EAL24020.1 422 hypothetical protein FLJ10842 [Homo sapiens]
GI:8922701 GenBank EAW83972.1 422 multiple substrate lipid kinase, isoform CRA_a [Homo sapiens]
GI:8922701 GenBank AIC56732.1 422 AGK, partial [synthetic construct]
GI:8922701 GenBank AIC62773.1 422 AGK, partial [synthetic construct]
GI:8922701 RefSeq XP_005250078.1 422 PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Homo sapiens]
GI:8922701 SwissProt Q53H12.2 422 RecName: Full=Acylglycerol kinase, mitochondrial; Short=hAGK; AltName: Full=Multiple substrate lipid kinase; Short=HsMuLK; Short=MuLK; Short=Multi-substrate lipid kinase; Flags: Precursor [Homo sapiens]

Related Sequences to LMP002516 proteins

Reference Database Accession Length Protein Name
GI:8922701 DBBJ BAD96489.1 422 multi-substrate lipid kinase variant, partial [Homo sapiens]
GI:8922701 GenBank AAQ02500.1 423 hypothetical protein FLJ10842, partial [synthetic construct]
GI:8922701 RefSeq XP_003813429.1 422 PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Pan paniscus]
GI:8922701 RefSeq XP_008964192.1 422 PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Pan paniscus]
GI:8922701 RefSeq XP_008964193.1 422 PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Pan paniscus]
GI:8922701 RefSeq XP_008964194.1 422 PREDICTED: acylglycerol kinase, mitochondrial isoform X1 [Pan paniscus]