Gene/Proteome Database (LMPD)
Proteins
toll-like receptor 4 precursor | |
---|---|
Refseq ID | NP_067272 |
Protein GI | 10946594 |
UniProt ID | Q9QUK6 |
mRNA ID | NM_021297 |
Length | 835 |
RefSeq Status | PROVISIONAL |
MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT | |
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2811 peptide sequence: MMPPWLLARTLIMALFFSCLTPGSL mat_peptide: 26..835 product: Toll-like receptor 4 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QUK6.1) calculated_mol_wt: 92727 peptide sequence: NPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0009897 | IEA:Ensembl | C | external side of plasma membrane |
GO:0005887 | IEA:Ensembl | C | integral component of plasma membrane |
GO:0046696 | IEA:Ensembl | C | lipopolysaccharide receptor complex |
GO:0048471 | IEA:Ensembl | C | perinuclear region of cytoplasm |
GO:0004888 | IEA:InterPro | F | transmembrane signaling receptor activity |
GO:0002322 | IMP:MGI | P | B cell proliferation involved in immune response |
GO:0007252 | IMP:MGI | P | I-kappaB phosphorylation |
GO:0002755 | IEA:InterPro | P | MyD88-dependent toll-like receptor signaling pathway |
GO:0002218 | IMP:MGI | P | activation of innate immune response |
GO:0071222 | IDA:MGI | P | cellular response to lipopolysaccharide |
GO:0071223 | IMP:MGI | P | cellular response to lipoteichoic acid |
GO:0071260 | IEA:Ensembl | P | cellular response to mechanical stimulus |
GO:0050829 | IMP:MGI | P | defense response to Gram-negative bacterium |
GO:0032497 | IEA:Ensembl | P | detection of lipopolysaccharide |
GO:0045087 | IEA:UniProtKB-KW | P | innate immune response |
GO:0032609 | IGI:MGI | P | interferon-gamma production |
GO:0031663 | IDA:MGI | P | lipopolysaccharide-mediated signaling pathway |
GO:0042116 | IEA:Ensembl | P | macrophage activation |
GO:0002537 | IMP:MGI | P | nitric oxide production involved in inflammatory response |
GO:0030890 | IMP:MGI | P | positive regulation of B cell proliferation |
GO:0070374 | IDA:MGI | P | positive regulation of ERK1 and ERK2 cascade |
GO:0043123 | IDA:MGI | P | positive regulation of I-kappaB kinase/NF-kappaB signaling |
GO:0046330 | IDA:MGI | P | positive regulation of JNK cascade |
GO:0045348 | IMP:MGI | P | positive regulation of MHC class II biosynthetic process |
GO:0042346 | IEA:Ensembl | P | positive regulation of NF-kappaB import into nucleus |
GO:0051092 | IEA:Ensembl | P | positive regulation of NF-kappaB transcription factor activity |
GO:0032722 | IEA:Ensembl | P | positive regulation of chemokine production |
GO:0045359 | IMP:MGI | P | positive regulation of interferon-beta biosynthetic process |
GO:0032733 | IDA:MGI | P | positive regulation of interleukin-10 production |
GO:0045084 | IEA:Ensembl | P | positive regulation of interleukin-12 biosynthetic process |
GO:0032755 | IDA:MGI | P | positive regulation of interleukin-6 production |
GO:0045416 | IEA:Ensembl | P | positive regulation of interleukin-8 biosynthetic process |
GO:0032757 | IEA:Ensembl | P | positive regulation of interleukin-8 production |
GO:0050671 | IMP:MGI | P | positive regulation of lymphocyte proliferation |
GO:0060907 | IMP:MGI | P | positive regulation of macrophage cytokine production |
GO:0045429 | IMP:MGI | P | positive regulation of nitric oxide biosynthetic process |
GO:0070430 | IDA:MGI | P | positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway |
GO:0070434 | IDA:MGI | P | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
GO:0032874 | IDA:MGI | P | positive regulation of stress-activated MAPK cascade |
GO:0042535 | IEA:Ensembl | P | positive regulation of tumor necrosis factor biosynthetic process |
GO:0032760 | IDA:MGI | P | positive regulation of tumor necrosis factor production |
GO:0050707 | IEA:InterPro | P | regulation of cytokine secretion |
GO:0009617 | IMP:MGI | P | response to bacterium |
GO:0032496 | IMP:MGI | P | response to lipopolysaccharide |
GO:0034142 | IEA:InterPro | P | toll-like receptor 4 signaling pathway |
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Similarity | Belongs to the Toll-like receptor family. |
Similarity | Contains TIR domain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002524 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
10946594 | RefSeq | NP_067272 | 835 | toll-like receptor 4 precursor |
Identical Sequences to LMP002524 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:10946594 | GenBank | AAD29272.1 | 835 | toll-like receptor 4 [Mus musculus] |
GI:10946594 | GenBank | AAF05317.1 | 835 | toll-like receptor 4 [Mus musculus] |
GI:10946594 | GenBank | ABH65778.1 | 835 | Sequence 99 from patent US 7029861 |
GI:10946594 | GenBank | EDL31078.1 | 835 | toll-like receptor 4 [Mus musculus] |
GI:10946594 | GenBank | AGA16686.1 | 835 | toll-like receptor 4 [Mus musculus] |
GI:10946594 | SwissProt | Q9QUK6.1 | 835 | RecName: Full=Toll-like receptor 4; AltName: CD_antigen=CD284; Flags: Precursor [Mus musculus] |
Related Sequences to LMP002524 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:10946594 | DBBJ | BAE32498.1 | 835 | unnamed protein product [Mus musculus] |
GI:10946594 | GenBank | AAC99411.1 | 835 | toll-like receptor 4 mutant [Mus musculus] |
GI:10946594 | GenBank | AAF04278.1 | 835 | Toll-like receptor 4 [Mus musculus] |
GI:10946594 | GenBank | AAH29856.1 | 835 | Toll-like receptor 4 [Mus musculus] |
GI:10946594 | GenBank | ABH65779.1 | 835 | Sequence 104 from patent US 7029861 |
GI:10946594 | GenBank | AGA16685.1 | 835 | toll-like receptor 4 [Mus musculus] |