Gene/Proteome Database (LMPD)

LMPD ID
LMP002524
Gene ID
21898
Species
Mus musculus (Mouse)
Gene Name
toll-like receptor 4
Gene Symbol
Tlr4
Synonyms
Lps; Ly87; Ran/M1; Rasl2-8
Chromosome
4
Map Location
4 C1|4 34.66 cM

Proteins

toll-like receptor 4 precursor
Refseq ID NP_067272
Protein GI 10946594
UniProt ID Q9QUK6
mRNA ID NM_021297
Length 835
RefSeq Status PROVISIONAL
MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2811 peptide sequence: MMPPWLLARTLIMALFFSCLTPGSL mat_peptide: 26..835 product: Toll-like receptor 4 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QUK6.1) calculated_mol_wt: 92727 peptide sequence: NPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT

Gene Information

Entrez Gene ID
21898
Gene Name
toll-like receptor 4
Gene Symbol
Tlr4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009897 IEA:Ensembl C external side of plasma membrane
GO:0005887 IEA:Ensembl C integral component of plasma membrane
GO:0046696 IEA:Ensembl C lipopolysaccharide receptor complex
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0004888 IEA:InterPro F transmembrane signaling receptor activity
GO:0002218 IMP:MGI P activation of innate immune response
GO:0002322 IMP:MGI P B cell proliferation involved in immune response
GO:0071222 IDA:MGI P cellular response to lipopolysaccharide
GO:0071223 IMP:MGI P cellular response to lipoteichoic acid
GO:0071260 IEA:Ensembl P cellular response to mechanical stimulus
GO:0050829 IMP:MGI P defense response to Gram-negative bacterium
GO:0032497 IEA:Ensembl P detection of lipopolysaccharide
GO:0007252 IMP:MGI P I-kappaB phosphorylation
GO:0045087 IEA:UniProtKB-KW P innate immune response
GO:0032609 IGI:MGI P interferon-gamma production
GO:0031663 IDA:MGI P lipopolysaccharide-mediated signaling pathway
GO:0042116 IEA:Ensembl P macrophage activation
GO:0002755 IEA:InterPro P MyD88-dependent toll-like receptor signaling pathway
GO:0002537 IMP:MGI P nitric oxide production involved in inflammatory response
GO:0030890 IMP:MGI P positive regulation of B cell proliferation
GO:0032722 IEA:Ensembl P positive regulation of chemokine production
GO:0070374 IDA:MGI P positive regulation of ERK1 and ERK2 cascade
GO:0043123 IDA:MGI P positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045359 IMP:MGI P positive regulation of interferon-beta biosynthetic process
GO:0032733 IDA:MGI P positive regulation of interleukin-10 production
GO:0045084 IEA:Ensembl P positive regulation of interleukin-12 biosynthetic process
GO:0032755 IDA:MGI P positive regulation of interleukin-6 production
GO:0045416 IEA:Ensembl P positive regulation of interleukin-8 biosynthetic process
GO:0032757 IEA:Ensembl P positive regulation of interleukin-8 production
GO:0046330 IDA:MGI P positive regulation of JNK cascade
GO:0050671 IMP:MGI P positive regulation of lymphocyte proliferation
GO:0060907 IMP:MGI P positive regulation of macrophage cytokine production
GO:0045348 IMP:MGI P positive regulation of MHC class II biosynthetic process
GO:0042346 IEA:Ensembl P positive regulation of NF-kappaB import into nucleus
GO:0051092 IEA:Ensembl P positive regulation of NF-kappaB transcription factor activity
GO:0045429 IMP:MGI P positive regulation of nitric oxide biosynthetic process
GO:0070430 IDA:MGI P positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 IDA:MGI P positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0032874 IDA:MGI P positive regulation of stress-activated MAPK cascade
GO:0042535 IEA:Ensembl P positive regulation of tumor necrosis factor biosynthetic process
GO:0032760 IDA:MGI P positive regulation of tumor necrosis factor production
GO:0050707 IEA:InterPro P regulation of cytokine secretion
GO:0009617 IMP:MGI P response to bacterium
GO:0032496 IMP:MGI P response to lipopolysaccharide
GO:0034142 IEA:InterPro P toll-like receptor 4 signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR017241 Toll-like receptor
IPR027168 Toll-like receptor 4

UniProt Annotations

Entry Information

Gene Name
toll-like receptor 4
Protein Entry
TLR4_MOUSE
UniProt ID
Q9QUK6
Species
Mouse

Comments

Comment Type Description
Similarity Belongs to the Toll-like receptor family.
Similarity Contains TIR domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP002524 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10946594 RefSeq NP_067272 835 toll-like receptor 4 precursor

Identical Sequences to LMP002524 proteins

Reference Database Accession Length Protein Name
GI:10946594 GenBank AAD29272.1 835 toll-like receptor 4 [Mus musculus]
GI:10946594 GenBank AAF05317.1 835 toll-like receptor 4 [Mus musculus]
GI:10946594 GenBank ABH65778.1 835 Sequence 99 from patent US 7029861
GI:10946594 GenBank EDL31078.1 835 toll-like receptor 4 [Mus musculus]
GI:10946594 GenBank AGA16686.1 835 toll-like receptor 4 [Mus musculus]
GI:10946594 SwissProt Q9QUK6.1 835 RecName: Full=Toll-like receptor 4; AltName: CD_antigen=CD284; Flags: Precursor [Mus musculus]

Related Sequences to LMP002524 proteins

Reference Database Accession Length Protein Name
GI:10946594 DBBJ BAE32498.1 835 unnamed protein product [Mus musculus]
GI:10946594 GenBank AAC99411.1 835 toll-like receptor 4 mutant [Mus musculus]
GI:10946594 GenBank AAF04278.1 835 Toll-like receptor 4 [Mus musculus]
GI:10946594 GenBank AAH29856.1 835 Toll-like receptor 4 [Mus musculus]
GI:10946594 GenBank ABH65779.1 835 Sequence 104 from patent US 7029861
GI:10946594 GenBank AGA16685.1 835 toll-like receptor 4 [Mus musculus]