Gene/Proteome Database (LMPD)

LMPD ID
LMP002533
Gene ID
22337
Species
Mus musculus (Mouse)
Gene Name
vitamin D receptor
Gene Symbol
Vdr
Synonyms
Nr1i1
Alternate Names
vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1
Chromosome
15
Map Location
15 F1|15

Proteins

vitamin D3 receptor
Refseq ID NP_033530
Protein GI 31543944
UniProt ID P48281
mRNA ID NM_009504
Length 422
RefSeq Status VALIDATED
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS

Gene Information

Entrez Gene ID
22337
Gene Name
vitamin D receptor
Gene Symbol
Vdr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:1902098 IEA:Ensembl F calcitriol binding
GO:0008434 IEA:InterPro F calcitriol receptor activity
GO:0004879 IDA:MGI F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:1902121 IEA:Ensembl F lithocholic acid binding
GO:0038186 IEA:Ensembl F lithocholic acid receptor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0070644 IEA:Ensembl F vitamin D response element binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006816 IMP:MGI P calcium ion transport
GO:0000902 IEA:Ensembl P cell morphogenesis
GO:0006874 IMP:MGI P cellular calcium ion homeostasis
GO:0046697 IEA:Ensembl P decidualization
GO:0050892 IMP:MGI P intestinal absorption
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0007595 IMP:MGI P lactation
GO:0060745 IMP:MGI P mammary gland branching involved in pregnancy
GO:0007275 IMP:MGI P multicellular organismal development
GO:0010839 IEA:Ensembl P negative regulation of keratinocyte proliferation
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0045892 ISO:MGI P negative regulation of transcription, DNA-templated
GO:0009887 IMP:MGI P organ morphogenesis
GO:0060058 IMP:MGI P positive regulation of apoptotic process involved in mammary gland involution
GO:0045618 IEA:Ensembl P positive regulation of keratinocyte differentiation
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0010980 IEA:Ensembl P positive regulation of vitamin D 24-hydroxylase activity
GO:0060558 IMP:BHF-UCL P regulation of calcidiol 1-monooxygenase activity
GO:0006355 IDA:MGI P regulation of transcription, DNA-templated
GO:0001501 IMP:MGI P skeletal system development

KEGG Pathway Links

KEGG Pathway ID Description
mmu04961 Endocrine and other factor-regulated calcium reabsorption
mmu04978 Mineral absorption
mmu05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR000324 Vitamin D receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
vitamin D receptor
Protein Entry
VDR_MOUSE
UniProt ID
P48281
Species
Mouse

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. {ECO:0000250}.
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis (By similarity). {ECO:0000250}.
Induction By 1,25-dihydroxyvitamin D(3) in kidney. {ECO:0000269|PubMed:14528024}.
Interaction Q925T6:Grip1; NbExp=2; IntAct=EBI-346797, EBI-537752; Q00403:GTF2B (xeno); NbExp=2; IntAct=EBI-346797, EBI-389564; Q9Y6Q9:NCOA3 (xeno); NbExp=2; IntAct=EBI-346797, EBI-81196; Q13573:SNW1 (xeno); NbExp=2; IntAct=EBI-346797, EBI-632715;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002533 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31543944 RefSeq NP_033530 422 vitamin D3 receptor

Identical Sequences to LMP002533 proteins

Reference Database Accession Length Protein Name
GI:31543944 DBBJ BAC26911.1 422 unnamed protein product [Mus musculus]
GI:31543944 DBBJ BAE32738.1 422 unnamed protein product [Mus musculus]
GI:31543944 GenBank AAH06716.1 422 Vitamin D receptor [Mus musculus]
GI:31543944 GenBank EDL04218.1 422 vitamin D receptor [Mus musculus]
GI:31543944 SwissProt P48281.2 422 RecName: Full=Vitamin D3 receptor; Short=VDR; AltName: Full=1,25-dihydroxyvitamin D3 receptor; AltName: Full=Nuclear receptor subfamily 1 group I member 1 [Mus musculus]

Related Sequences to LMP002533 proteins

Reference Database Accession Length Protein Name
GI:31543944 DBBJ BAA06737.1 422 vitamin D receptor [Mus musculus]
GI:31543944 DBBJ BAE33856.1 422 unnamed protein product [Mus musculus]
GI:31543944 EMBL CAJ18502.1 422 Vdr [Mus musculus]
GI:31543944 GenBank AAA41089.1 423 1,25-dihydroxyvitamin D-3 receptor [Rattus norvegicus]
GI:31543944 GenBank EDL87095.1 423 vitamin D receptor [Rattus norvegicus]
GI:31543944 SwissProt P13053.1 423 RecName: Full=Vitamin D3 receptor; Short=VDR; AltName: Full=1,25-dihydroxyvitamin D3 receptor; AltName: Full=Nuclear receptor subfamily 1 group I member 1 [Rattus norvegicus]