Gene/Proteome Database (LMPD)
LMPD ID
LMP002534
Gene ID
Species
Mus musculus (Mouse)
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A6A
Gene Symbol
Synonyms
UDPGT; UDPGT 1-6; UGT1-06; UGT1.6; Ugt1a6; Ugt1a7
Alternate Names
UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1A6; phenol UDP-glucuronosyltransferase; UDP glycosyltransferase 1 family, polypeptide A6
Chromosome
1
Map Location
1 D|1
EC Number
2.4.1.17
Proteins
| UDP-glucuronosyltransferase 1-6 precursor | |
|---|---|
| Refseq ID | NP_659545 |
| Protein GI | 33186906 |
| UniProt ID | Q64435 |
| mRNA ID | NM_145079 |
| Length | 531 |
| RefSeq Status | VALIDATED |
| MACLLPAAQTLPAGFLFLVLWASVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIMVLVPEVNLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKDSATLSFLRENKFDALFTDPAMPCGVILAEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYLYYCLYSKYEIIASDLLKRDVSLPSLHQNSLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH | |
| sig_peptide: 1..26 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2703 peptide sequence: MACLLPAAQTLPAGFLFLVLWASVLG mat_peptide: 27..531 product: UDP-glucuronosyltransferase 1-6 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64435.1) calculated_mol_wt: 57754 peptide sequence: DKLLVVPQDGSHWLSMKEIVEHLSERGHDIMVLVPEVNLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKDSATLSFLRENKFDALFTDPAMPCGVILAEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYLYYCLYSKYEIIASDLLKRDVSLPSLHQNSLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH | |
Gene Information
Entrez Gene ID
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A6A
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005743 | IDA:MGI | C | mitochondrial inner membrane |
| GO:0015020 | IDA:MGI | F | glucuronosyltransferase activity |
| GO:0019585 | IDA:MGI | P | glucuronate metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002213 | UDP-glucuronosyl/UDP-glucosyltransferase |
UniProt Annotations
Entry Information
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A6A
Protein Entry
UD16_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=Q64435-1; Sequence=Displayed; |
| Catalytic Activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate. |
| Induction | By dioxin. |
| Similarity | Belongs to the UDP-glycosyltransferase family. {ECO:0000305}. |
| Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in liver, kidney and at very low levels in colon. {ECO:0000269|PubMed:14672974}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002534 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 33186906 | RefSeq | NP_659545 | 531 | UDP-glucuronosyltransferase 1-6 precursor |
Identical Sequences to LMP002534 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:33186906 | GenBank | AAA65979.1 | 531 | UDP glucuronosyltransferase [Mus musculus] |
| GI:33186906 | SwissProt | Q64435.1 | 531 | RecName: Full=UDP-glucuronosyltransferase 1-6; Short=UDPGT 1-6; Short=UGT1*6; Short=UGT1-06; Short=UGT1.6; AltName: Full=Phenol UDP-glucuronosyltransferase; AltName: Full=UDP-glucuronosyltransferase 1A6; Short=UGT1A6; AltName: Full=UGP1A1; AltName: Full=UGT1A7; Flags: Precursor [Mus musculus] |
Related Sequences to LMP002534 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:33186906 | DBBJ | BAA13483.1 | 531 | phenol UDP-glucuronosyltransferase [Mus musculus] |
| GI:33186906 | GenBank | AAA51871.1 | 531 | UGT1.6 [Mus musculus] |
| GI:33186906 | GenBank | AAH26561.1 | 531 | UDP glucuronosyltransferase 1 family, polypeptide A6B [Mus musculus] |
| GI:33186906 | GenBank | AAP48596.1 | 531 | UDP glycosyltransferase 1 family polypeptide A7 [Mus musculus] |
| GI:33186906 | GenBank | AAH69940.1 | 531 | Ugt1a6a protein [Mus musculus] |
| GI:33186906 | GenBank | EDL40121.1 | 531 | mCG14318, isoform CRA_a [Mus musculus] |