Gene/Proteome Database (LMPD)

LMPD ID
LMP002538
Gene ID
11529
Species
Mus musculus (Mouse)
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol
Adh7
Synonyms
AI325182; Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e; Adh3-t; Adh4; Adt-1
Alternate Names
alcohol dehydrogenase class 4 mu/sigma chain; ADH-C2; IV ADH; retinol dehydrogenase; alcohol dehydrogenase 4; gastric alcohol dehydrogenase; alcohol dehydrogenase 3 complex; alcohol dehydrogenase 3 temporal; alcohol dehydrogenase class IV mu/sigma chain
Chromosome
3
Map Location
3 G3|3 64.13 cM
EC Number
1.1.1.1

Proteins

alcohol dehydrogenase class 4 mu/sigma chain
Refseq ID NP_033756
Protein GI 31560625
UniProt ID Q64437
mRNA ID NM_009626
Length 374
RefSeq Status VALIDATED
MGTAGKVIKCKAAVLWGVNQPFSIEEIEVAPPKAKEVRVKILATGICRTDDHIIKGSMVSKFPVIVGHEAVGVVESVGEGVTTVRPGDKVIPLFLPQCRECNACLNPEGNLCIRSDLTGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKVDGAAPPEKACLIGCGFSTGYGAAVKTAKVTPGSTCVVFGLGGVGLSVIMGCKAAGASRIIGIDINKDKFQKALAVGATECISPKDSTKPISEVLSDMTGNTIQYTFEVIGRLETMVDALSSCHMNYGTSVVVGAPPSAKMLTYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLDQLITHTLPFNNINEGFELLYSGKSIRTVLTF

Gene Information

Entrez Gene ID
11529
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol
Adh7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005576 IEA:Ensembl C extracellular region
GO:0005622 IDA:MGI C intracellular
GO:0004024 IEA:InterPro F alcohol dehydrogenase activity, zinc-dependent
GO:0004022 IDA:MGI F alcohol dehydrogenase (NAD) activity
GO:0004031 IEA:Ensembl F aldehyde oxidase activity
GO:0035276 IEA:InterPro F ethanol binding
GO:0016491 TAS:MGI F oxidoreductase activity
GO:0019841 IEA:InterPro F retinol binding
GO:0004745 IDA:MGI F retinol dehydrogenase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006068 IMP:MGI P ethanol catabolic process
GO:0006069 IEA:InterPro P ethanol oxidation
GO:1900116 IEA:Ensembl P extracellular negative regulation of signal transduction
GO:0010430 IEA:Ensembl P fatty acid omega-oxidation
GO:0009617 IEA:Ensembl P response to bacterium
GO:0045471 IEA:Ensembl P response to ethanol
GO:0042573 IMP:MGI P retinoic acid metabolic process
GO:0042572 IMP:MGI P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu00982 Drug metabolism - cytochrome P450
mmu00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR013149 Alcohol dehydrogenase, C-terminal
IPR028635 Alcohol dehydrogenase family, zinc-type, class-IV subfamily
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Protein Entry
ADH7_MOUSE
UniProt ID
Q64437
Species
Mouse

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
Function Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homodimer.
Tissue Specificity High expression in the stomach mucosa. Lower expression in eye, thymus, skin and ovary. Very low expression in small intestine, liver and uterus.

Identical and Related Proteins

Unique RefSeq proteins for LMP002538 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31560625 RefSeq NP_033756 374 alcohol dehydrogenase class 4 mu/sigma chain

Identical Sequences to LMP002538 proteins

Reference Database Accession Length Protein Name
GI:31560625 DBBJ BAE43215.1 374 unnamed protein product [Mus musculus]
GI:31560625 GenBank AAM22808.1 374 alcohol dehydrogenase class 4 [Mus musculus]
GI:31560625 GenBank AAH47267.1 374 Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Mus musculus]
GI:31560625 GenBank EDL12104.1 374 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Mus musculus]
GI:31560625 RefSeq XP_006500982.1 374 PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Mus musculus]
GI:31560625 SwissProt Q64437.2 374 RecName: Full=Alcohol dehydrogenase class 4 mu/sigma chain; AltName: Full=ADH-C2; AltName: Full=Alcohol dehydrogenase 7; AltName: Full=Alcohol dehydrogenase class IV mu/sigma chain; AltName: Full=Gastric alcohol dehydrogenase; AltName: Full=Retinol dehydrogenase [Mus musculus]

Related Sequences to LMP002538 proteins

Reference Database Accession Length Protein Name
GI:31560625 DBBJ BAE26071.1 374 unnamed protein product [Mus musculus]
GI:31560625 GenBank AAA76735.1 374 class IV alcohol dehydrogenase [Mus musculus]
GI:31560625 GenBank AAC53124.1 374 class IV alcohol dehydrogenase [Mus musculus]
GI:31560625 GenBank AAM22809.1 374 alcohol dehydrogenase class 4 [Mus musculus]
GI:31560625 RefSeq XP_006500983.1 371 PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X2 [Mus musculus]
GI:31560625 RefSeq XP_006970384.1 374 PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain [Peromyscus maniculatus bairdii]