Gene/Proteome Database (LMPD)

LMPD ID
LMP002539
Gene ID
69060
Species
Mus musculus (Mouse)
Gene Name
pancreatic lipase
Gene Symbol
Pnlip
Synonyms
1810007A24Rik; PL; PTL
Alternate Names
pancreatic triacylglycerol lipase; pancreatic triglyceride lipase
Chromosome
19
Map Location
19 D2|19 54.46 cM
EC Number
3.1.1.3

Proteins

pancreatic triacylglycerol lipase precursor
Refseq ID NP_081201
Protein GI 37674236
UniProt ID Q6P8U6
mRNA ID NM_026925
Length 465
RefSeq Status PROVISIONAL
MLMLWTFAVLLGAVAGREVCFDKLGCFSDDAPWSGTLDRPLKALPWSPAQINTRFLLYTNENPDNYQLITSDASNIRNSNFRTNRKTRIIIHGFIDKGEENWLSDMCKNMFRVESVNCICVDWKGGSRTTYTQATQNVRVVGAEVALLVNVLQSDLGYSLNNVHLIGHSLGSHIAGEAGKRTFGAIGRITGLDPAEPYFQGTPEEVRLDPTDAQFVDAIHTDAGPIIPNLGFGMSQTVGHLDFFPNGGIEMPGCQKNILSQIVDIDGIWEGTRNFAACNHLRSYKFYTDSIVNPTGFAGFSCSSYSLFTANKCFPCGSGGCPQMGHYADRYPGKTSRLYQTFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSKQYEVFKGSLQPGTSHVNEFDSDVDVGDLQKVKFIWYNNVINPTLPKVGASRITVERNDGRVFNFCSQETVREDVLLTLSPC
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1693 peptide sequence: MLMLWTFAVLLGAVAG mat_peptide: 17..465 product: Pancreatic triacylglycerol lipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6P8U6.1) calculated_mol_wt: 49753 peptide sequence: REVCFDKLGCFSDDAPWSGTLDRPLKALPWSPAQINTRFLLYTNENPDNYQLITSDASNIRNSNFRTNRKTRIIIHGFIDKGEENWLSDMCKNMFRVESVNCICVDWKGGSRTTYTQATQNVRVVGAEVALLVNVLQSDLGYSLNNVHLIGHSLGSHIAGEAGKRTFGAIGRITGLDPAEPYFQGTPEEVRLDPTDAQFVDAIHTDAGPIIPNLGFGMSQTVGHLDFFPNGGIEMPGCQKNILSQIVDIDGIWEGTRNFAACNHLRSYKFYTDSIVNPTGFAGFSCSSYSLFTANKCFPCGSGGCPQMGHYADRYPGKTSRLYQTFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSKQYEVFKGSLQPGTSHVNEFDSDVDVGDLQKVKFIWYNNVINPTLPKVGASRITVERNDGRVFNFCSQETVREDVLLTLSPC

Gene Information

Entrez Gene ID
69060
Gene Name
pancreatic lipase
Gene Symbol
Pnlip
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004806 IEA:UniProtKB-EC F triglyceride lipase activity
GO:0030299 IMP:MGI P intestinal cholesterol absorption
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04975 Fat digestion and absorption
mmu04972 Pancreatic secretion
mmu04977 Vitamin digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein_lipase_LIPH
IPR002331 Pancreatic lipase
IPR001024 PLAT/LH2 domain
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase
Protein Entry
LIPP_MOUSE
UniProt ID
Q6P8U6
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. {ECO:0000269|PubMed:10769148}.
Function Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). {ECO:0000250}.
Induction By colipase/CLPS in the presence of bile salts.
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Pancreas. {ECO:0000269|PubMed:10769148}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002539 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
37674236 RefSeq NP_081201 465 pancreatic triacylglycerol lipase precursor

Identical Sequences to LMP002539 proteins

Reference Database Accession Length Protein Name
GI:37674236 GenBank AAQ90020.1 465 pancreatic triglyceride lipase [Mus musculus]
GI:37674236 GenBank AAH61061.1 465 Pancreatic lipase [Mus musculus]
GI:37674236 GenBank EDL01803.1 465 mCG10680, isoform CRA_b [Mus musculus]
GI:37674236 GenBank ADS21270.1 465 Sequence 13 from patent US 7771960
GI:37674236 GenBank AFG81083.1 465 Sequence 13 from patent US 8138316
GI:37674236 SwissProt Q6P8U6.1 465 RecName: Full=Pancreatic triacylglycerol lipase; Short=PL; Short=PTL; Short=Pancreatic lipase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002539 proteins

Reference Database Accession Length Protein Name
GI:37674236 GenBank AAA79888.1 465 pancreatic triglyceride lipase [Rattus norvegicus]
GI:37674236 GenBank EDL01804.1 482 mCG10680, isoform CRA_c [Mus musculus]
GI:37674236 GenBank EDL94538.1 465 pancreatic lipase, isoform CRA_a [Rattus norvegicus]
GI:37674236 GenBank AFG81082.1 465 Sequence 12 from patent US 8138316
GI:37674236 PRF - 465 lipase [Rattus norvegicus]
GI:37674236 RefSeq NP_037293.1 465 pancreatic triacylglycerol lipase precursor [Rattus norvegicus]