Gene/Proteome Database (LMPD)
LMPD ID
LMP002540
Gene ID
Species
Homo sapiens (Human)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 3
Gene Symbol
Synonyms
LPAAT-GAMMA1; LPAAT3
Alternate Names
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; 1-AGPAT 3; 1-AGP acyltransferase 3; lysophosphatidic acid acyltransferase gamma; lysophosphatidic acid acyltransferase-gamma1
Chromosome
21
Map Location
21q22.3
EC Number
2.3.1.51
Summary
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma | |
|---|---|
| Refseq ID | NP_001032642 |
| Protein GI | 83267874 |
| UniProt ID | Q9NRZ7 |
| mRNA ID | NM_001037553 |
| Length | 376 |
| RefSeq Status | REVIEWED |
| MGLLAFLKTQFVLHLLVGFVFVVSGLVINFVQLCTLALWPVSKQLYRRLNCRLAYSLWSQLVMLLEWWSCTECTLFTDQATVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIVFCKRKWEEDRDTVVEGLRRLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTVAAVYDVTLNFRGNKNPSLLGILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKGMFPGEQFKPARRPWTLLNFLSWATILLSPLFSFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTEIEKGSSYGNQEFKKKE | |
Gene Information
Entrez Gene ID
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0003841 | NAS:UniProtKB | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0016024 | IEA:UniProtKB-UniPathway | P | CDP-diacylglycerol biosynthetic process |
| GO:0044255 | TAS:Reactome | P | cellular lipid metabolic process |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0006654 | TAS:Reactome | P | phosphatidic acid biosynthetic process |
| GO:0008654 | NAS:UniProtKB | P | phospholipid biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0019432 | TAS:Reactome | P | triglyceride biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00561 | Glycerolipid metabolism |
| hsa00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_120906 | Synthesis of PA |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002123 | Phospholipid/glycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 3
Protein Entry
PLCC_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Gamma-1; IsoId=Q9NRZ7-1; Sequence=Displayed; Name=2; Synonyms=Gamma-2; IsoId=Q9NRZ7-2; Sequence=VSP_005072; Name=3; IsoId=Q9NRZ7-3; Sequence=VSP_013144; Note=No experimental confirmation available.; |
| Biophysicochemical Properties | Kinetic parameters: KM=4.78 uM for LPA sn-1 C18:1 ; KM=21.53 uM for C18:1-CoA ; Vmax=6.35 nmol/min/mg enzyme toward LPA sn-1 C18:1 ; Vmax=0.74 nmol/min/mg enzyme toward C18:1-CoA ; |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. |
| Function | Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. |
| Tissue Specificity | Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002540 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 83267874 | RefSeq | NP_001032642 | 376 | 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma |
Identical Sequences to LMP002540 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:83267874 | GenBank | AHD69731.1 | 376 | Sequence 1320 from patent US 8586006 |
| GI:83267874 | GenBank | AHD69732.1 | 376 | Sequence 1321 from patent US 8586006 |
| GI:83267874 | GenBank | AIC51937.1 | 376 | AGPAT3, partial [synthetic construct] |
| GI:83267874 | GenBank | AIC56809.1 | 376 | AGPAT3, partial [synthetic construct] |
| GI:83267874 | RefSeq | XP_006724092.1 | 376 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X3 [Homo sapiens] |
| GI:83267874 | RefSeq | XP_006724093.1 | 376 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X4 [Homo sapiens] |
Related Sequences to LMP002540 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:83267874 | EMBL | CAC88314.1 | 376 | unnamed protein product [Homo sapiens] |
| GI:83267874 | RefSeq | XP_003277406.1 | 376 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1 [Nomascus leucogenys] |
| GI:83267874 | RefSeq | XP_003277407.1 | 376 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2 [Nomascus leucogenys] |
| GI:83267874 | RefSeq | XP_003277408.1 | 376 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 3 [Nomascus leucogenys] |
| GI:83267874 | RefSeq | XP_004092377.1 | 376 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [Nomascus leucogenys] |
| GI:83267874 | RefSeq | XP_005261216.1 | 463 | PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [Homo sapiens] |