Gene/Proteome Database (LMPD)

LMPD ID
LMP002545
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
Synonyms
NPIK; PI4K-BETA; PI4K92; PI4KBETA; PI4KIIIBETA; PIK4CB
Chromosome
1
Map Location
1q21
EC Number
2.7.1.67

Proteins

phosphatidylinositol 4-kinase beta isoform 1
Refseq ID NP_002642
Protein GI 4505809
UniProt ID Q9UBF8
mRNA ID NM_002651
Length 828
RefSeq Status VALIDATED
MRFLEARSLAVAMGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
phosphatidylinositol 4-kinase beta isoform 2
Refseq ID NP_001185702
Protein GI 311771621
UniProt ID Q9UBF8
mRNA ID NM_001198773
Length 801
RefSeq Status VALIDATED
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
phosphatidylinositol 4-kinase beta isoform 2
Refseq ID NP_001185703
Protein GI 311771623
UniProt ID Q9UBF8
mRNA ID NM_001198774
Length 801
RefSeq Status VALIDATED
Protein sequence is identical to GI:311771621 (mRNA isoform)
phosphatidylinositol 4-kinase beta isoform 3
Refseq ID NP_001185704
Protein GI 311771625
UniProt ID Q9UBF8
mRNA ID NM_001198775
Length 484
RefSeq Status VALIDATED
MAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM

Gene Information

Entrez Gene ID
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0005737 TAS:ProtInc C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005768 TAS:ProtInc C endosome
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005886 IEA:Ensembl C plasma membrane
GO:0004430 TAS:Reactome F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0006898 TAS:ProtInc P receptor-mediated endocytosis
GO:0007165 TAS:ProtInc P signal transduction
GO:0044281 TAS:Reactome P small molecule metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6352 3-phosphoinositide biosynthesis
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120836 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR027003 Phosphatidylinositol 4-kinase
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Protein Entry
Q9UBF8_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1 ; Synonyms=NPIK-B ; IsoId=Q9UBF8-1; Sequence=Displayed; Name=2 ; Synonyms=NPIK-C ; IsoId=Q9UBF8-2; Sequence=VSP_050627; Note=Contains a phosphoserine at position 294.; Name=3; IsoId=Q9UBF8-3; Sequence=VSP_037133;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Enzyme Regulation Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity).
Function Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
Interaction Q9H3P7:ACBD3; NbExp=4; IntAct=EBI-1053214, EBI-1791792; P03495:NS (xeno); NbExp=2; IntAct=EBI-1053214, EBI-2548993;
Sequence Caution Sequence=BAA21661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=CAH70326.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=EAW53450.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
Similarity Contains 1 PI3K/PI4K domain. {ECO
Similarity Contains 1 PIK helical domain. {ECO
Subcellular Location Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex.
Subunit Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6. Interacts with NCS1/FREQ in a calcium-independent manner (By similarity). Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner (By similarity). This binding competes with NCS1/FREQ binding (By similarity).
Tissue Specificity Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002545 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505809 RefSeq NP_002642 828 phosphatidylinositol 4-kinase beta isoform 1
311771621 RefSeq NP_001185702 801 phosphatidylinositol 4-kinase beta isoform 2
311771625 RefSeq NP_001185704 484 phosphatidylinositol 4-kinase beta isoform 3

Identical Sequences to LMP002545 proteins

Reference Database Accession Length Protein Name
GI:4505809 DBBJ BAA21661.1 828 phosphatidylinositol 4-kinase [Homo sapiens]
GI:311771621 DBBJ BAJ20243.2 801 phosphatidylinositol 4-kinase, catalytic, beta, partial [synthetic construct]
GI:311771621 GenBank AAH00029.1 801 PI4KB protein [Homo sapiens]
GI:311771621 GenBank AAH40300.1 801 PI4KB protein [Homo sapiens]
GI:311771621 GenBank EAW53449.1 801 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Homo sapiens]
GI:4505809 GenBank EAW53450.1 828 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_b [Homo sapiens]
GI:4505809 GenBank AHD70216.1 828 Sequence 2305 from patent US 8586006
GI:311771621 GenBank AIC62558.1 801 PI4KB, partial [synthetic construct]
GI:311771621 RefSeq NP_001185703.1 801 phosphatidylinositol 4-kinase beta isoform 2 [Homo sapiens]
GI:311771625 RefSeq XP_004451774.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform 6 [Dasypus novemcinctus]
GI:311771625 RefSeq XP_005895011.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X6 [Bos mutus]
GI:311771625 RefSeq XP_006900168.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X5 [Elephantulus edwardii]
GI:311771625 RefSeq XP_007975416.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X6 [Chlorocebus sabaeus]
GI:311771625 RefSeq XP_008968665.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X7 [Pan paniscus]
GI:311771625 RefSeq XP_010385495.1 484 PREDICTED: phosphatidylinositol 4-kinase beta isoform X7 [Rhinopithecus roxellana]

Related Sequences to LMP002545 proteins

Reference Database Accession Length Protein Name
GI:311771625 DBBJ BAA21661.1 828 phosphatidylinositol 4-kinase [Homo sapiens]
GI:311771621 GenBank AAQ02384.1 802 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, partial [synthetic construct]
GI:311771625 GenBank EAW53450.1 828 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_b [Homo sapiens]
GI:4505809 GenBank ABY40795.1 828 phosphatidylinositol 4-kinase, catalytic, beta (predicted) [Papio anubis]
GI:311771625 GenBank AHD70216.1 828 Sequence 2305 from patent US 8586006
GI:311771625 RefSeq NP_002642.1 828 phosphatidylinositol 4-kinase beta isoform 1 [Homo sapiens]
GI:311771621 RefSeq XP_002810293.1 801 PREDICTED: phosphatidylinositol 4-kinase beta isoform X4 [Pongo abelii]
GI:311771625 RefSeq NP_001185702.1 801 phosphatidylinositol 4-kinase beta isoform 2 [Homo sapiens]
GI:311771625 RefSeq NP_001185703.1 801 phosphatidylinositol 4-kinase beta isoform 2 [Homo sapiens]
GI:311771621 RefSeq XP_003775626.1 801 PREDICTED: phosphatidylinositol 4-kinase beta isoform X4 [Pongo abelii]
GI:4505809 RefSeq XP_002810292.2 828 PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Pongo abelii]
GI:311771621 RefSeq XP_004026675.1 801 PREDICTED: phosphatidylinositol 4-kinase beta isoform 1 [Gorilla gorilla gorilla]
GI:311771621 RefSeq XP_004026676.1 801 PREDICTED: phosphatidylinositol 4-kinase beta isoform 2 [Gorilla gorilla gorilla]
GI:4505809 RefSeq XP_004026677.1 828 PREDICTED: phosphatidylinositol 4-kinase beta isoform 3 [Gorilla gorilla gorilla]
GI:311771621 RefSeq XP_005245321.1 813 PREDICTED: phosphatidylinositol 4-kinase beta isoform X4 [Homo sapiens]
GI:4505809 RefSeq XP_007975407.1 828 PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Chlorocebus sabaeus]
GI:4505809 RefSeq XP_007975408.1 828 PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Chlorocebus sabaeus]
GI:4505809 RefSeq XP_009429463.1 828 PREDICTED: phosphatidylinositol 4-kinase beta [Pan troglodytes]