Gene/Proteome Database (LMPD)
Proteins
| phosphatidylinositol 4-kinase beta isoform 1 | |
|---|---|
| Refseq ID | NP_002642 |
| Protein GI | 4505809 |
| UniProt ID | Q9UBF8 |
| mRNA ID | NM_002651 |
| Length | 828 |
| RefSeq Status | VALIDATED |
| MRFLEARSLAVAMGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM | |
| phosphatidylinositol 4-kinase beta isoform 2 | |
|---|---|
| Refseq ID | NP_001185702 |
| Protein GI | 311771621 |
| UniProt ID | Q9UBF8 |
| mRNA ID | NM_001198773 |
| Length | 801 |
| RefSeq Status | VALIDATED |
| MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM | |
| phosphatidylinositol 4-kinase beta isoform 2 | |
|---|---|
| Refseq ID | NP_001185703 |
| Protein GI | 311771623 |
| UniProt ID | Q9UBF8 |
| mRNA ID | NM_001198774 |
| Length | 801 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:311771621 (mRNA isoform) | |
| phosphatidylinositol 4-kinase beta isoform 3 | |
|---|---|
| Refseq ID | NP_001185704 |
| Protein GI | 311771625 |
| UniProt ID | Q9UBF8 |
| mRNA ID | NM_001198775 |
| Length | 484 |
| RefSeq Status | VALIDATED |
| MAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | TAS:ProtInc | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005768 | TAS:ProtInc | C | endosome |
| GO:0000139 | TAS:Reactome | C | Golgi membrane |
| GO:0005741 | IEA:UniProtKB-KW | C | mitochondrial outer membrane |
| GO:0005886 | IEA:Ensembl | C | plasma membrane |
| GO:0004430 | TAS:Reactome | F | 1-phosphatidylinositol 4-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0048015 | IEA:InterPro | P | phosphatidylinositol-mediated signaling |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0006898 | TAS:ProtInc | P | receptor-mediated endocytosis |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6352 | 3-phosphoinositide biosynthesis |
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_120836 | Synthesis of PIPs at the Golgi membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| IPR027003 | Phosphatidylinositol 4-kinase |
| IPR015433 | Phosphatidylinositol Kinase |
| IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Protein Entry
Q9UBF8_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1 ; Synonyms=NPIK-B ; IsoId=Q9UBF8-1; Sequence=Displayed; Name=2 ; Synonyms=NPIK-C ; IsoId=Q9UBF8-2; Sequence=VSP_050627; Note=Contains a phosphoserine at position 294.; Name=3; IsoId=Q9UBF8-3; Sequence=VSP_037133; |
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Enzyme Regulation | Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity). |
| Function | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). |
| Interaction | Q9H3P7:ACBD3; NbExp=4; IntAct=EBI-1053214, EBI-1791792; P03495:NS (xeno); NbExp=2; IntAct=EBI-1053214, EBI-2548993; |
| Sequence Caution | Sequence=BAA21661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=CAH70326.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=EAW53450.1; Type=Erroneous gene model prediction; Evidence= ; |
| Similarity | Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. |
| Similarity | Contains 1 PI3K/PI4K domain. {ECO |
| Similarity | Contains 1 PIK helical domain. {ECO |
| Subcellular Location | Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. |
| Subunit | Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6. Interacts with NCS1/FREQ in a calcium-independent manner (By similarity). Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner (By similarity). This binding competes with NCS1/FREQ binding (By similarity). |
| Tissue Specificity | Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP002545 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4505809 | RefSeq | NP_002642 | 828 | phosphatidylinositol 4-kinase beta isoform 1 |
| 311771621 | RefSeq | NP_001185702 | 801 | phosphatidylinositol 4-kinase beta isoform 2 |
| 311771625 | RefSeq | NP_001185704 | 484 | phosphatidylinositol 4-kinase beta isoform 3 |
Identical Sequences to LMP002545 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505809 | DBBJ | BAA21661.1 | 828 | phosphatidylinositol 4-kinase [Homo sapiens] |
| GI:311771621 | DBBJ | BAJ20243.2 | 801 | phosphatidylinositol 4-kinase, catalytic, beta, partial [synthetic construct] |
| GI:311771621 | GenBank | AAH00029.1 | 801 | PI4KB protein [Homo sapiens] |
| GI:311771621 | GenBank | AAH40300.1 | 801 | PI4KB protein [Homo sapiens] |
| GI:311771621 | GenBank | EAW53449.1 | 801 | phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Homo sapiens] |
| GI:4505809 | GenBank | EAW53450.1 | 828 | phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_b [Homo sapiens] |
| GI:4505809 | GenBank | AHD70216.1 | 828 | Sequence 2305 from patent US 8586006 |
| GI:311771621 | GenBank | AIC62558.1 | 801 | PI4KB, partial [synthetic construct] |
| GI:311771621 | RefSeq | NP_001185703.1 | 801 | phosphatidylinositol 4-kinase beta isoform 2 [Homo sapiens] |
| GI:311771625 | RefSeq | XP_004451774.1 | 484 | PREDICTED: phosphatidylinositol 4-kinase beta isoform 6 [Dasypus novemcinctus] |
| GI:311771625 | RefSeq | XP_005895011.1 | 484 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X6 [Bos mutus] |
| GI:311771625 | RefSeq | XP_006900168.1 | 484 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X5 [Elephantulus edwardii] |
| GI:311771625 | RefSeq | XP_007975416.1 | 484 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X6 [Chlorocebus sabaeus] |
| GI:311771625 | RefSeq | XP_008968665.1 | 484 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X7 [Pan paniscus] |
| GI:311771625 | RefSeq | XP_010385495.1 | 484 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X7 [Rhinopithecus roxellana] |
Related Sequences to LMP002545 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:311771625 | DBBJ | BAA21661.1 | 828 | phosphatidylinositol 4-kinase [Homo sapiens] |
| GI:311771621 | GenBank | AAQ02384.1 | 802 | phosphatidylinositol 4-kinase, catalytic, beta polypeptide, partial [synthetic construct] |
| GI:311771625 | GenBank | EAW53450.1 | 828 | phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_b [Homo sapiens] |
| GI:4505809 | GenBank | ABY40795.1 | 828 | phosphatidylinositol 4-kinase, catalytic, beta (predicted) [Papio anubis] |
| GI:311771625 | GenBank | AHD70216.1 | 828 | Sequence 2305 from patent US 8586006 |
| GI:311771625 | RefSeq | NP_002642.1 | 828 | phosphatidylinositol 4-kinase beta isoform 1 [Homo sapiens] |
| GI:311771621 | RefSeq | XP_002810293.1 | 801 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X4 [Pongo abelii] |
| GI:311771625 | RefSeq | NP_001185702.1 | 801 | phosphatidylinositol 4-kinase beta isoform 2 [Homo sapiens] |
| GI:311771625 | RefSeq | NP_001185703.1 | 801 | phosphatidylinositol 4-kinase beta isoform 2 [Homo sapiens] |
| GI:311771621 | RefSeq | XP_003775626.1 | 801 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X4 [Pongo abelii] |
| GI:4505809 | RefSeq | XP_002810292.2 | 828 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Pongo abelii] |
| GI:311771621 | RefSeq | XP_004026675.1 | 801 | PREDICTED: phosphatidylinositol 4-kinase beta isoform 1 [Gorilla gorilla gorilla] |
| GI:311771621 | RefSeq | XP_004026676.1 | 801 | PREDICTED: phosphatidylinositol 4-kinase beta isoform 2 [Gorilla gorilla gorilla] |
| GI:4505809 | RefSeq | XP_004026677.1 | 828 | PREDICTED: phosphatidylinositol 4-kinase beta isoform 3 [Gorilla gorilla gorilla] |
| GI:311771621 | RefSeq | XP_005245321.1 | 813 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X4 [Homo sapiens] |
| GI:4505809 | RefSeq | XP_007975407.1 | 828 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Chlorocebus sabaeus] |
| GI:4505809 | RefSeq | XP_007975408.1 | 828 | PREDICTED: phosphatidylinositol 4-kinase beta isoform X1 [Chlorocebus sabaeus] |
| GI:4505809 | RefSeq | XP_009429463.1 | 828 | PREDICTED: phosphatidylinositol 4-kinase beta [Pan troglodytes] |