Gene/Proteome Database (LMPD)

LMPD ID
LMP002546
Gene ID
14137
Species
Mus musculus (Mouse)
Gene Name
farnesyl diphosphate farnesyl transferase 1
Gene Symbol
Fdft1
Synonyms
SQS; SS
Alternate Names
squalene synthase; squalene synthetase; FPP:FPP farnesyltransferase; farnesyl-diphosphate farnesyltransferase
Chromosome
14
Map Location
14 D1|14 33.24 cM
EC Number
2.5.1.21

Proteins

squalene synthase
Refseq ID NP_034321
Protein GI 34328173
UniProt ID P53798
mRNA ID NM_010191
Length 416
RefSeq Status PROVISIONAL
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGDIRHAICVFYLVLRALDTVEDDMSISVEKKIPLLCNFHTFLYDPEWRFTESKEKDRQVLEDFPTISLEFRNLAEKYQTVIDDICHRMGCGMAEFVDKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDIECANSMGLFLQKTNIIRDYLEDQQEGRKFWPQEVWGRYIKKLEDFAKPENVDVAVQCLNELITNTLQHIPDVLTYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRIPNSDPSSSKTKQVISKIRTQNLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH

Gene Information

Entrez Gene ID
14137
Gene Name
farnesyl diphosphate farnesyl transferase 1
Gene Symbol
Fdft1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004310 IEA:UniProtKB-EC F farnesyl-diphosphate farnesyltransferase activity
GO:0016491 IEA:UniProtKB-KW F oxidoreductase activity
GO:0051996 IEA:UniProtKB-EC F squalene synthase activity
GO:0006695 IEA:UniProtKB-KW P cholesterol biosynthetic process
GO:0045338 IEA:Ensembl P farnesyl diphosphate metabolic process
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894006 Activation of gene expression by SREBF (SREBP)
5893434 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006449 Farnesyl-diphosphate farnesyltransferase
IPR008949 Isoprenoid synthase domain
IPR002060 Squalene/phytoene synthase
IPR019845 Squalene/phytoene synthase, conserved site

UniProt Annotations

Entry Information

Gene Name
farnesyl diphosphate farnesyl transferase 1
Protein Entry
FDFT_MOUSE
UniProt ID
P53798
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
Similarity Belongs to the phytoene/squalene synthase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP002546 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
34328173 RefSeq NP_034321 416 squalene synthase

Identical Sequences to LMP002546 proteins

Reference Database Accession Length Protein Name
GI:34328173 DBBJ BAE40489.1 416 unnamed protein product [Mus musculus]
GI:34328173 GenBank EDL36069.1 416 farnesyl diphosphate farnesyl transferase 1 [Mus musculus]
GI:34328173 GenBank AAI38302.1 416 Farnesyl diphosphate farnesyl transferase 1 [Mus musculus]
GI:34328173 GenBank AAI38303.1 416 Farnesyl diphosphate farnesyl transferase 1 [Mus musculus]
GI:34328173 RefSeq XP_006518609.1 416 PREDICTED: squalene synthase isoform X1 [Mus musculus]
GI:34328173 SwissProt P53798.2 416 RecName: Full=Squalene synthase; Short=SQS; Short=SS; AltName: Full=FPP:FPP farnesyltransferase; AltName: Full=Farnesyl-diphosphate farnesyltransferase [Mus musculus]

Related Sequences to LMP002546 proteins

Reference Database Accession Length Protein Name
GI:34328173 DBBJ BAA06102.1 416 squalene synthase [Mus musculus]
GI:34328173 DBBJ BAE36836.1 416 unnamed protein product [Mus musculus]
GI:34328173 GenBank AAH81810.1 416 Farnesyl diphosphate farnesyl transferase 1 [Rattus norvegicus]
GI:34328173 GenBank EDL85317.1 416 farnesyl diphosphate farnesyl transferase 1 [Rattus norvegicus]
GI:34328173 PRF - 416 squalene synthase [Mus musculus]
GI:34328173 SwissProt Q02769.1 416 RecName: Full=Squalene synthase; Short=SQS; Short=SS; AltName: Full=FPP:FPP farnesyltransferase; AltName: Full=Farnesyl-diphosphate farnesyltransferase [Rattus norvegicus]