Gene/Proteome Database (LMPD)

LMPD ID
LMP002551
Gene ID
19013
Species
Mus musculus (Mouse)
Gene Name
peroxisome proliferator activated receptor alpha
Gene Symbol
Ppara
Synonyms
4933429D07Rik; AW742785; Nr1c1; PPAR-alpha; PPARalpha; Ppar
Alternate Names
peroxisome proliferator-activated receptor alpha; nuclear receptor subfamily 1 group C member 1
Chromosome
15
Map Location
15 E2|15 40.42 cM

Proteins

peroxisome proliferator-activated receptor alpha
Refseq ID NP_001106889
Protein GI 164663880
UniProt ID P23204
mRNA ID NM_001113418
Length 468
RefSeq Status VALIDATED
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
peroxisome proliferator-activated receptor alpha
Refseq ID NP_035274
Protein GI 31543500
UniProt ID P23204
mRNA ID NM_011144
Length 468
RefSeq Status VALIDATED
Protein sequence is identical to GI:164663880 (mRNA isoform)

Gene Information

Entrez Gene ID
19013
Gene Name
peroxisome proliferator activated receptor alpha
Gene Symbol
Ppara
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 TAS:MGI C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0000978 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001077 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190 IDA:MGI F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0008144 ISS:UniProtKB F drug binding
GO:0004879 IEA:Ensembl F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008289 IDA:UniProtKB F lipid binding
GO:0046982 TAS:UniProtKB F protein heterodimerization activity
GO:0004872 IDA:MGI F receptor activity
GO:0043565 IDA:UniProtKB F sequence-specific DNA binding
GO:0003700 IMP:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0003707 TAS:MGI F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0035095 IEA:Ensembl P behavioral response to nicotine
GO:0032922 IDA:UniProtKB P circadian regulation of gene expression
GO:0070166 IMP:MGI P enamel mineralization
GO:0008544 IMP:MGI P epidermis development
GO:0006631 IMP:MGI P fatty acid metabolic process
GO:0006006 TAS:MGI P glucose metabolic process
GO:0007507 IEA:Ensembl P heart development
GO:0006629 TAS:MGI P lipid metabolic process
GO:0042157 IEA:Ensembl P lipoprotein metabolic process
GO:0032099 IMP:UniProtKB P negative regulation of appetite
GO:0045776 IEA:Ensembl P negative regulation of blood pressure
GO:0010887 IEA:Ensembl P negative regulation of cholesterol storage
GO:1901215 IEA:Ensembl P negative regulation of neuron death
GO:0032091 IEA:Ensembl P negative regulation of protein binding
GO:0010871 IEA:Ensembl P negative regulation of receptor biosynthetic process
GO:0010891 IEA:Ensembl P negative regulation of sequestering of triglyceride
GO:2000678 IEA:Ensembl P negative regulation of transcription regulatory region DNA binding
GO:0046321 IMP:BHF-UCL P positive regulation of fatty acid oxidation
GO:0045722 IMP:MGI P positive regulation of gluconeogenesis
GO:0045944 IDA:MGI P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IMP:UniProtKB P positive regulation of transcription, DNA-templated
GO:0072366 IEA:Ensembl P regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752 IDA:UniProtKB P regulation of circadian rhythm
GO:0019217 IMP:MGI P regulation of fatty acid metabolic process
GO:0010468 IMP:MGI P regulation of gene expression
GO:0072363 IEA:Ensembl P regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IEA:Ensembl P regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0006355 TAS:MGI P regulation of transcription, DNA-templated
GO:0001666 IEA:Ensembl P response to hypoxia
GO:0032868 IEA:Ensembl P response to insulin
GO:0042060 IMP:MGI P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
mmu04932 Non-alcoholic fatty liver disease (NAFLD)
mmu04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003074 Peroxisome proliferator-activated receptor
IPR003076 Peroxisome proliferator-activated receptor, alpha
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator activated receptor alpha
Protein Entry
PPARA_MOUSE
UniProt ID
P23204
Species
Mouse

Comments

Comment Type Description
Developmental Stage It appears first at 13.5 dpc and increases until birth.
Disease Note=Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs, herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia.
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:12955147, ECO:0000269|PubMed:19646743, ECO:0000269|PubMed:20159955}.
Interaction O88559:Men1; NbExp=2; IntAct=EBI-5273083, EBI-3990176;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:20159955}.
Subunit Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2. {ECO:0000269|PubMed:10788465, ECO:0000269|PubMed:16950137, ECO:0000269|PubMed:18719582, ECO:0000269|PubMed:20159955, ECO:0000269|PubMed:9325263, ECO:0000269|PubMed:9627117}.
Tissue Specificity Highly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.

Identical and Related Proteins

Unique RefSeq proteins for LMP002551 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
164663880 RefSeq NP_001106889 468 peroxisome proliferator-activated receptor alpha

Identical Sequences to LMP002551 proteins

Reference Database Accession Length Protein Name
GI:164663880 GenBank EDL04427.1 468 peroxisome proliferator activated receptor alpha, isoform CRA_a [Mus musculus]
GI:164663880 RefSeq XP_006520682.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X1 [Mus musculus]
GI:164663880 RefSeq XP_006520683.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X2 [Mus musculus]
GI:164663880 RefSeq XP_006520684.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X3 [Mus musculus]
GI:164663880 RefSeq XP_006520685.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X4 [Mus musculus]
GI:164663880 RefSeq XP_006520686.1 468 PREDICTED: peroxisome proliferator-activated receptor alpha isoform X5 [Mus musculus]

Related Sequences to LMP002551 proteins

Reference Database Accession Length Protein Name
GI:164663880 EMBL CAA40856.1 468 peroxisome proliferator activated receptor [Mus musculus]
GI:164663880 GenBank ABJ48133.1 468 Sequence 12 from patent US 7115640
GI:164663880 GenBank EDL04428.1 496 peroxisome proliferator activated receptor alpha, isoform CRA_b, partial [Mus musculus]
GI:164663880 GenBank AEN39529.1 468 Sequence 12 from patent US 7998986
GI:164663880 pat US 468 Sequence 3 from patent US 5686596
GI:164663880 PRF - 468 steroid hormone receptor [Mus musculus]