Gene/Proteome Database (LMPD)

LMPD ID
LMP002556
Gene ID
30814
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group IIE
Gene Symbol
PLA2G2E
Synonyms
GIIE sPLA2; sPLA2-IIE
Alternate Names
group IIE secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2E
Chromosome
1
Map Location
1p36.13
EC Number
3.1.1.4

Proteins

group IIE secretory phospholipase A2 precursor
Refseq ID NP_055404
Protein GI 7657461
UniProt ID Q9NZK7
mRNA ID NM_014589
Length 142
RefSeq Status VALIDATED
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2041 peptide sequence: MKSPHVLVFLCLLVALVTG mat_peptide: 20..142 product: Group IIE secretory phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9NZK7.1) calculated_mol_wt: 13966 peptide sequence: NLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC

Gene Information

Entrez Gene ID
30814
Gene Name
phospholipase A2, group IIE
Gene Symbol
PLA2G2E
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:Reactome C extracellular region
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 TAS:ProtInc F phospholipase A2 activity
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006954 TAS:ProtInc P inflammatory response
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0036148 TAS:Reactome P phosphatidylglycerol acyl-chain remodeling
GO:0036149 TAS:Reactome P phosphatidylinositol acyl-chain remodeling
GO:0036150 TAS:Reactome P phosphatidylserine acyl-chain remodeling
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion
hsa04014 Ras signaling pathway
hsa04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR001211 Phospholipase A2
IPR013090 Phospholipase A2, active site
IPR016090 Phospholipase A2 domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IIE
Protein Entry
PA2GE_HUMAN
UniProt ID
Q9NZK7
Species
Human

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO
Cofactor Name=Ca(2+); Xref=ChEBI
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Similarity Belongs to the phospholipase A2 family.
Subcellular Location Secreted.
Tissue Specificity Restricted to the brain, heart, lung, and placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP002556 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7657461 RefSeq NP_055404 142 group IIE secretory phospholipase A2 precursor

Identical Sequences to LMP002556 proteins

Reference Database Accession Length Protein Name
GI:7657461 DBBJ BAG73531.1 142 phospholipase A2, group IIE, partial [synthetic construct]
GI:7657461 GenBank AAY07212.1 142 Sequence 30 from patent US 6872557
GI:7657461 GenBank AAI41620.1 142 Phospholipase A2, group IIE [synthetic construct]
GI:7657461 GenBank AAI40241.1 142 Phospholipase A2, group IIE, partial [synthetic construct]
GI:7657461 GenBank AEU43365.1 142 Sequence 114 from patent US 8052970
GI:7657461 GenBank AGF22441.1 142 Sequence 7 from patent US 8372594

Related Sequences to LMP002556 proteins

Reference Database Accession Length Protein Name
GI:7657461 GenBank AAH69116.1 140 PLA2G2E protein, partial [Homo sapiens]
GI:7657461 GenBank AAW12532.1 154 Sequence 8 from patent US 6812017
GI:7657461 GenBank EAW94906.1 154 phospholipase A2, group IIE [Homo sapiens]
GI:7657461 RefSeq XP_003891294.1 142 PREDICTED: group IIE secretory phospholipase A2 [Papio anubis]
GI:7657461 RefSeq XP_004024859.1 142 PREDICTED: group IIE secretory phospholipase A2 [Gorilla gorilla gorilla]
GI:7657461 RefSeq XP_005544625.1 142 PREDICTED: group IIE secretory phospholipase A2 [Macaca fascicularis]