Gene/Proteome Database (LMPD)

LMPD ID
LMP002561
Gene ID
192654
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group XV
Gene Symbol
Pla2g15
Synonyms
ACS; C87498; LLPL; Lpla2; Lypla3
Alternate Names
group XV phospholipase A2; lysophospholipase 3; 1-O-acylceramide synthase; lysosomal phospholipase A2; LCAT-like lysophospholipase
Chromosome
8
Map Location
8 D3|8
EC Number
2.3.1.-

Proteins

group XV phospholipase A2 precursor
Refseq ID NP_598553
Protein GI 19527008
UniProt ID Q8VEB4
mRNA ID NM_133792
Length 412
RefSeq Status PROVISIONAL
MDRHLCTCRETQLRSGLLLPLFLLMMLADLTLPAQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKKTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRATQFPDGVDVRVPGFGETFSMEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQMYGGPVVLVAHSMGNVYMLYFLQRQPQVWKDKYIHAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSHEKVFVYTPTTNYTLRDYHRFFRDIGFEDGWFMRQDTEGLVEAMTPPGVELHCLYGTGVPTPNSFYYESFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHRVSLQELPGSEHIEMLANATTLAYLKRVLLEP
sig_peptide: 1..33 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3816 peptide sequence: MDRHLCTCRETQLRSGLLLPLFLLMMLADLTLP mat_peptide: 34..412 product: Group XV phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8VEB4.1) calculated_mol_wt: 43510 peptide sequence: AQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKKTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRATQFPDGVDVRVPGFGETFSMEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQMYGGPVVLVAHSMGNVYMLYFLQRQPQVWKDKYIHAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSHEKVFVYTPTTNYTLRDYHRFFRDIGFEDGWFMRQDTEGLVEAMTPPGVELHCLYGTGVPTPNSFYYESFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHRVSLQELPGSEHIEMLANATTLAYLKRVLLEP

Gene Information

Entrez Gene ID
192654
Gene Name
phospholipase A2, group XV
Gene Symbol
Pla2g15
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 ISS:UniProtKB C lysosome
GO:0005739 IDA:MGI C mitochondrion
GO:0047499 IDA:MGI F calcium-independent phospholipase A2 activity
GO:0008374 ISS:UniProtKB F O-acyltransferase activity
GO:0006672 IDA:MGI P ceramide metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0046470 IEA:Ensembl P phosphatidylcholine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
mmu00564 Glycerophospholipid metabolism
ko04142 Lysosome
mmu04142 Lysosome

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group XV
Protein Entry
PAG15_MOUSE
UniProt ID
Q8VEB4
Species
Mouse

Comments

Comment Type Description
Function Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid. {ECO:0000269|PubMed:11790796}.
Ptm N-glycosylated. {ECO:0000269|PubMed:11790796}.
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular Location Secreted {ECO:0000250}. Lysosome.

Identical and Related Proteins

Unique RefSeq proteins for LMP002561 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19527008 RefSeq NP_598553 412 group XV phospholipase A2 precursor

Identical Sequences to LMP002561 proteins

Reference Database Accession Length Protein Name
GI:19527008 GenBank EDL11348.1 412 lysophospholipase 3, isoform CRA_a [Mus musculus]
GI:19527008 GenBank ABZ54191.1 412 Sequence 13 from patent US 7319015
GI:19527008 GenBank ACK31032.1 412 Sequence 1 from patent US 7462757
GI:19527008 GenBank ACW43774.1 412 Sequence 13 from patent US 7582442
GI:19527008 GenBank AEU43367.1 412 Sequence 116 from patent US 8052970
GI:19527008 GenBank AEU43465.1 412 Sequence 214 from patent US 8052970

Related Sequences to LMP002561 proteins

Reference Database Accession Length Protein Name
GI:19527008 DBBJ BAE32987.1 412 unnamed protein product [Mus musculus]
GI:19527008 GenBank AAS66767.1 413 lysosomal phospholipase A2 [Rattus norvegicus]
GI:19527008 GenBank AAH98894.1 413 Phospholipase A2, group XV [Rattus norvegicus]
GI:19527008 GenBank EDL92440.1 413 rCG51420, isoform CRA_b [Rattus norvegicus]
GI:19527008 GenBank AEU43524.1 413 Sequence 273 from patent US 8052970
GI:19527008 RefSeq NP_001004277.1 413 group XV phospholipase A2 precursor [Rattus norvegicus]