Gene/Proteome Database (LMPD)

LMPD ID
LMP002565
Gene ID
19210
Species
Mus musculus (Mouse)
Gene Name
phosphatidylserine synthase 1
Gene Symbol
Ptdss1
Synonyms
AU044268; AW539008; PSS-1; mKIAA0024
Alternate Names
phosphatidylserine synthase 1; PtdSer Synthase-1; ptdSer synthase 1; serine-exchange enzyme I
Chromosome
13
Map Location
13 B-C1|13 34.54 cM
EC Number
2.7.8.29

Proteins

phosphatidylserine synthase 1
Refseq ID NP_032985
Protein GI 31560651
UniProt ID Q99LH2
mRNA ID NM_008959
Length 473
RefSeq Status VALIDATED
MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIISLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVMLWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPEISWHHGKGSKGSEDSPPKHSSNHESHSSRRRNRHSKSKVTNGVGKK

Gene Information

Entrez Gene ID
19210
Gene Name
phosphatidylserine synthase 1
Gene Symbol
Ptdss1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:UniProtKB C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 ISS:UniProtKB C membrane
GO:0016740 IEA:UniProtKB-KW F transferase activity
GO:0006659 IEA:UniProtKB-UniPathway P phosphatidylserine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR004277 Phosphatidyl serine synthase

UniProt Annotations

Entry Information

Gene Name
phosphatidylserine synthase 1
Protein Entry
PTSS1_MOUSE
UniProt ID
Q99LH2
Species
Mouse

Comments

Comment Type Description
Catalytic Activity L-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
Disruption Phenotype Null mice are viable, fertile and have a normal life span. Toal serine exchange is reduced up to 85%, but apart from in liver, the phosphatatidylserine content was unaltered. Elimination of either Pss1 or Pss2, but not both, is compatible with mouse viability. Mice can tolerate as little as 10% serine-exchange activity and are viable with small amounts of phosphatidylserine and phosphatidylethanolamine content. to phosphatidylethanolamine. {ECO:0000269|PubMed:18343815}.
Enzyme Regulation Potently inhibited by choline in the mitochondria-associated membrane (MAM). Very little inhibition by choline in the endoplasmic reticulum (ER) per se. {ECO:0000269|PubMed:10938271}.
Function Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. {ECO:0000269|PubMed:10432300, ECO:0000269|PubMed:9516423}.
Pathway Phospholipid metabolism; phosphatidylserine biosynthesis.
Similarity Belongs to the phosphatidyl serine synthase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10938271}; Multi-pass membrane protein {ECO:0000269|PubMed:10938271}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Tissue Specificity Expressed in kidney, testis, lung, skeletal muscle, liver brain, heart and spleen with highest expression in testis, liver, heart and brain. {ECO:0000269|PubMed:10432300}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002565 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31560651 RefSeq NP_032985 473 phosphatidylserine synthase 1

Identical Sequences to LMP002565 proteins

Reference Database Accession Length Protein Name
GI:31560651 DBBJ BAC29660.1 473 unnamed protein product [Mus musculus]
GI:31560651 DBBJ BAC35656.1 473 unnamed protein product [Mus musculus]
GI:31560651 DBBJ BAC39555.1 473 unnamed protein product [Mus musculus]
GI:31560651 DBBJ BAE23459.1 473 unnamed protein product [Mus musculus]
GI:31560651 GenBank AAH03260.1 473 Phosphatidylserine synthase 1 [Mus musculus]
GI:31560651 SwissProt Q99LH2.1 473 RecName: Full=Phosphatidylserine synthase 1; Short=PSS-1; Short=PtdSer synthase 1; AltName: Full=Serine-exchange enzyme I [Mus musculus]

Related Sequences to LMP002565 proteins

Reference Database Accession Length Protein Name
GI:31560651 DBBJ BAC40117.1 473 unnamed protein product [Mus musculus]
GI:31560651 DBBJ BAD32151.1 487 mKIAA0024 protein, partial [Mus musculus]
GI:31560651 GenBank AAH87129.1 473 Phosphatidylserine synthase 1 [Rattus norvegicus]
GI:31560651 RefSeq XP_005368204.1 473 PREDICTED: phosphatidylserine synthase 1 [Microtus ochrogaster]
GI:31560651 RefSeq XP_006977686.1 473 PREDICTED: phosphatidylserine synthase 1 [Peromyscus maniculatus bairdii]
GI:31560651 RefSeq XP_008846082.1 473 PREDICTED: phosphatidylserine synthase 1 [Nannospalax galili]