Gene/Proteome Database (LMPD)
LMPD ID
LMP002568
Gene ID
Species
Homo sapiens (Human)
Gene Name
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Gene Symbol
Synonyms
COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS
Alternate Names
prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1
Chromosome
9
Map Location
9q32-q33.3
EC Number
1.14.99.1
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Orthologs
Proteins
| prostaglandin G/H synthase 1 isoform 1 precursor | |
|---|---|
| Refseq ID | NP_000953 |
| Protein GI | 18104967 |
| UniProt ID | P23219 |
| mRNA ID | NM_000962 |
| Length | 599 |
| RefSeq Status | REVIEWED |
| MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
| prostaglandin G/H synthase 1 isoform 2 precursor | |
|---|---|
| Refseq ID | NP_542158 |
| Protein GI | 18104969 |
| UniProt ID | P23219 |
| mRNA ID | NM_080591 |
| Length | 562 |
| RefSeq Status | REVIEWED |
| MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
| sig_peptide: 1..23 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P23219.2) calculated_mol_wt: 2709 peptide sequence: MSRSLLLWFLLFLLLLPPLPVLL mat_peptide: 24..599 product: Prostaglandin G/H synthase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P23219.2) calculated_mol_wt: 65996 peptide sequence: ADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL sig_peptide: 1..23 calculated_mol_wt: 2709 peptide sequence: MSRSLLLWFLLFLLLLPPLPVLL mat_peptide: 24..551 product: prostaglandin G/H synthase 1 isoform 3 calculated_mol_wt: 60596 peptide sequence: ADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL sig_peptide: 1..23 calculated_mol_wt: 2709 peptide sequence: MSRSLLLWFLLFLLLLPPLPVLL mat_peptide: 24..562 product: prostaglandin G/H synthase 1 isoform 2 calculated_mol_wt: 61823 peptide sequence: ADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
| prostaglandin G/H synthase 1 isoform 4 | |
|---|---|
| Refseq ID | NP_001258094 |
| Protein GI | 403310641 |
| UniProt ID | P23219 |
| mRNA ID | NM_001271165 |
| Length | 490 |
| RefSeq Status | REVIEWED |
| MLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
| prostaglandin G/H synthase 1 isoform 5 | |
|---|---|
| Refseq ID | NP_001258095 |
| Protein GI | 403310643 |
| UniProt ID | P23219 |
| mRNA ID | NM_001271166 |
| Length | 453 |
| RefSeq Status | REVIEWED |
| MLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
| prostaglandin G/H synthase 1 isoform 6 | |
|---|---|
| Refseq ID | NP_001258297 |
| Protein GI | 406035323 |
| UniProt ID | P23219 |
| mRNA ID | NM_001271368 |
| Length | 537 |
| RefSeq Status | REVIEWED |
| MRKPRLMNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL | |
Gene Information
Entrez Gene ID
Gene Name
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | ISS:UniProtKB | C | cytoplasm |
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0043231 | ISS:UniProtKB | C | intracellular membrane-bounded organelle |
| GO:0005634 | ISS:UniProtKB | C | nucleus |
| GO:0001750 | IEA:Ensembl | C | photoreceptor outer segment |
| GO:0051213 | IEA:UniProtKB-KW | F | dioxygenase activity |
| GO:0020037 | IEA:InterPro | F | heme binding |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004601 | TAS:Reactome | F | peroxidase activity |
| GO:0004666 | IDA:BHF-UCL | F | prostaglandin-endoperoxide synthase activity |
| GO:0019369 | TAS:Reactome | P | arachidonic acid metabolic process |
| GO:0019371 | IDA:BHF-UCL | P | cyclooxygenase pathway |
| GO:0006954 | IEA:InterPro | P | inflammatory response |
| GO:0006629 | NAS:ProtInc | P | lipid metabolic process |
| GO:0001516 | ISS:UniProtKB | P | prostaglandin biosynthetic process |
| GO:0008217 | ISS:UniProtKB | P | regulation of blood pressure |
| GO:0042127 | IEA:Ensembl | P | regulation of cell proliferation |
| GO:0006979 | IEA:InterPro | P | response to oxidative stress |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006805 | TAS:Reactome | P | xenobiotic metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150149 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
Domain Information
UniProt Annotations
Entry Information
Gene Name
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Protein Entry
PGH1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=Long; IsoId=P23219-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P23219-2; Sequence=VSP_004673; Name=3; IsoId=P23219-3; Sequence=VSP_053936, VSP_004673; Name=4; IsoId=P23219-4; Sequence=VSP_046932; Note=No experimental confirmation available.; Name=5; Synonyms=1b3; IsoId=P23219-5; Sequence=VSP_054862; Name=6; Synonyms=1b2; IsoId=P23219-6; Sequence=VSP_054863; |
| Catalytic Activity | Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. |
| Cofactor | Name=heme b; Xref=ChEBI |
| Function | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. |
| Miscellaneous | Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PGHS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PGHS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation. |
| Miscellaneous | PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long- term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration. |
| Miscellaneous | The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme- containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site. |
| Pathway | Lipid metabolism; prostaglandin biosynthesis. |
| Sequence Caution | Sequence=CAI14716.1; Type=Erroneous gene model prediction; Evidence= ; |
| Similarity | Belongs to the prostaglandin G/H synthase family. |
| Similarity | Contains 1 EGF-like domain. {ECO |
| Subcellular Location | Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. |
| Subunit | Homodimer. |
| Web Resource | Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ptgs1/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002568 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18104967 | RefSeq | NP_000953 | 599 | prostaglandin G/H synthase 1 isoform 1 precursor |
| 18104969 | RefSeq | NP_542158 | 562 | prostaglandin G/H synthase 1 isoform 2 precursor |
| 403310641 | RefSeq | NP_001258094 | 490 | prostaglandin G/H synthase 1 isoform 4 |
| 403310643 | RefSeq | NP_001258095 | 453 | prostaglandin G/H synthase 1 isoform 5 |
| 406035323 | RefSeq | NP_001258297 | 537 | prostaglandin G/H synthase 1 isoform 6 |
Identical Sequences to LMP002568 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:406035323 | DBBJ | BAG58214.1 | 537 | unnamed protein product [Homo sapiens] |
| GI:18104967 | EMBL | CAY39332.1 | 599 | unnamed protein product [Homo sapiens] |
| GI:18104969 | EMBL | CAY39333.1 | 562 | unnamed protein product [Homo sapiens] |
| GI:403310641 | EMBL | CBX54354.1 | 490 | unnamed protein product [Homo sapiens] |
| GI:406035323 | GenBank | ABS90954.1 | 537 | Sequence 6 from patent US 7198928 |
| GI:18104967 | GenBank | ABS90956.1 | 599 | Sequence 10 from patent US 7198928 |
| GI:18104967 | GenBank | ADS46306.1 | 599 | Sequence 22 from patent US 7799518 |
| GI:18104969 | GenBank | ADS46307.1 | 562 | Sequence 24 from patent US 7799518 |
| GI:18104967 | GenBank | ADS96632.1 | 599 | Sequence 8 from patent US 7829535 |
| GI:18104967 | GenBank | AHD69914.1 | 599 | Sequence 1503 from patent US 8586006 |
| GI:18104969 | GenBank | AHD69915.1 | 562 | Sequence 1504 from patent US 8586006 |
| GI:403310643 | RefSeq | NP_001258296.1 | 453 | prostaglandin G/H synthase 1 isoform 5 [Homo sapiens] |
| GI:406035323 | RefSeq | XP_006717255.1 | 537 | PREDICTED: prostaglandin G/H synthase 1 isoform X3 [Homo sapiens] |
| GI:18104967 | SwissProt | P23219.2 | 599 | RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP002568 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:403310641 | DBBJ | BAF82711.1 | 599 | unnamed protein product [Homo sapiens] |
| GI:406035323 | EMBL | CAY39333.1 | 562 | unnamed protein product [Homo sapiens] |
| GI:403310643 | EMBL | CAY39333.1 | 562 | unnamed protein product [Homo sapiens] |
| GI:18104967 | GenBank | AAA03630.1 | 599 | prostaglandin endoperoxide synthase [Homo sapiens] |
| GI:403310641 | GenBank | AAA03630.1 | 599 | prostaglandin endoperoxide synthase [Homo sapiens] |
| GI:403310641 | GenBank | AAB21215.1 | 599 | prostaglandin endoperoxide synthase [Homo sapiens] |
| GI:18104967 | GenBank | AAB21215.1 | 599 | prostaglandin endoperoxide synthase [Homo sapiens] |
| GI:18104969 | GenBank | AAB22216.1 | 562 | prostaglandin G/H synthase [Homo sapiens] |
| GI:406035323 | GenBank | AAB22216.1 | 562 | prostaglandin G/H synthase [Homo sapiens] |
| GI:403310643 | GenBank | AAB22216.1 | 562 | prostaglandin G/H synthase [Homo sapiens] |
| GI:18104967 | GenBank | AAB22217.1 | 599 | prostaglandin G/H synthase [Homo sapiens] |
| GI:403310641 | GenBank | AAB22217.1 | 599 | prostaglandin G/H synthase [Homo sapiens] |
| GI:403310641 | GenBank | ABL56181.1 | 599 | Sequence 1 from patent US 7141401 |
| GI:403310643 | GenBank | EAW87529.1 | 562 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), isoform CRA_a [Homo sapiens] |
| GI:18104969 | GenBank | EAW87529.1 | 562 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), isoform CRA_a [Homo sapiens] |
| GI:406035323 | GenBank | EAW87529.1 | 562 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), isoform CRA_a [Homo sapiens] |
| GI:18104967 | GenBank | ABM83367.1 | 599 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [synthetic construct] |
| GI:403310641 | GenBank | ABY15139.1 | 599 | Sequence 514 from patent US 7306913 |
| GI:406035323 | GenBank | ABY15140.1 | 562 | Sequence 515 from patent US 7306913 |
| GI:18104969 | GenBank | ABY15140.1 | 562 | Sequence 515 from patent US 7306913 |
| GI:403310643 | GenBank | ABY15140.1 | 562 | Sequence 515 from patent US 7306913 |
| GI:18104967 | GenBank | ACM80510.1 | 599 | Sequence 6008 from patent US 6812339 |
| GI:403310643 | GenBank | AHD69915.1 | 562 | Sequence 1504 from patent US 8586006 |
| GI:18104967 | GenBank | AIK97765.1 | 609 | prostaglandin H synthase-1 [synthetic construct] |
| GI:403310643 | RefSeq | NP_542158.1 | 562 | prostaglandin G/H synthase 1 isoform 2 precursor [Homo sapiens] |
| GI:18104969 | RefSeq | XP_001088041.1 | 562 | PREDICTED: prostaglandin G/H synthase 1 isoform 4 [Macaca mulatta] |
| GI:406035323 | RefSeq | XP_001087917.2 | 537 | PREDICTED: prostaglandin G/H synthase 1 isoform 3 [Macaca mulatta] |
| GI:18104969 | RefSeq | XP_005580933.1 | 562 | PREDICTED: prostaglandin G/H synthase 1 isoform X4 [Macaca fascicularis] |
| GI:406035323 | RefSeq | XP_005580935.1 | 537 | PREDICTED: prostaglandin G/H synthase 1 isoform X6 [Macaca fascicularis] |
| GI:18104969 | RefSeq | XP_007966351.1 | 621 | PREDICTED: prostaglandin G/H synthase 1 isoform X2 [Chlorocebus sabaeus] |