Gene/Proteome Database (LMPD)
LMPD ID
LMP002578
Gene ID
Species
Homo sapiens (Human)
Gene Name
farnesyltransferase, CAAX box, alpha
Gene Symbol
Synonyms
FPTA; PGGT1A; PTAR2
Alternate Names
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; FTase-alpha; GGTase-I-alpha; farnesyl-protein transferase alpha-subunit; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; protein prenyltransferase alpha subunit repeat containing 2
Chromosome
8
Map Location
8p11
EC Number
2.5.1.58
Summary
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Orthologs
Proteins
| protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | |
|---|---|
| Refseq ID | NP_002018 |
| Protein GI | 4503771 |
| UniProt ID | P49354 |
| mRNA ID | NM_002027 |
| Length | 379 |
| RefSeq Status | REVIEWED |
| MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ | |
Gene Information
Entrez Gene ID
Gene Name
farnesyltransferase, CAAX box, alpha
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005953 | IDA:UniProtKB | C | CAAX-protein geranylgeranyltransferase complex |
| GO:0005737 | TAS:ProtInc | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005875 | IDA:BHF-UCL | C | microtubule associated complex |
| GO:0005965 | IDA:UniProtKB | C | protein farnesyltransferase complex |
| GO:0004662 | IEA:UniProtKB-EC | F | CAAX-protein geranylgeranyltransferase activity |
| GO:0043014 | IDA:BHF-UCL | F | alpha-tubulin binding |
| GO:0008017 | IDA:BHF-UCL | F | microtubule binding |
| GO:0004660 | IDA:UniProtKB | F | protein farnesyltransferase activity |
| GO:0004661 | IDA:UniProtKB | F | protein geranylgeranyltransferase activity |
| GO:0006915 | TAS:Reactome | P | apoptotic process |
| GO:0006921 | TAS:Reactome | P | cellular component disassembly involved in execution phase of apoptosis |
| GO:0007603 | TAS:Reactome | P | phototransduction, visible light |
| GO:0090045 | IDA:BHF-UCL | P | positive regulation of deacetylase activity |
| GO:0090044 | IDA:BHF-UCL | P | positive regulation of tubulin deacetylation |
| GO:0018343 | IDA:UniProtKB | P | protein farnesylation |
| GO:0018344 | IDA:UniProtKB | P | protein geranylgeranylation |
| GO:0022400 | TAS:Reactome | P | regulation of rhodopsin mediated signaling pathway |
| GO:0016056 | TAS:Reactome | P | rhodopsin mediated signaling pathway |
| GO:0007179 | TAS:ProtInc | P | transforming growth factor beta receptor signaling pathway |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00900 | Terpenoid backbone biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_163919 | Inactivation, recovery and regulation of the phototransduction cascade |
| REACT_163722 | The phototransduction cascade |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002088 | Protein prenyltransferase, alpha subunit |
UniProt Annotations
Entry Information
Gene Name
farnesyltransferase, CAAX box, alpha
Protein Entry
FNTA_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49354-1; Sequence=Displayed; Name=2; IsoId=P49354-2; Sequence=VSP_036468; |
| Catalytic Activity | Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. |
| Catalytic Activity | Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. |
| Enzyme Regulation | Activated by the AGRIN-induced phosphorylation which is mediated by MUSK. |
| Function | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO |
| Interaction | P49356:FNTB; NbExp=7; IntAct=EBI-602336, EBI-602349; |
| Ptm | Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity). |
| Similarity | Belongs to the protein prenyltransferase subunit alpha family. |
| Similarity | Contains 5 PFTA repeats. {ECO |
| Subunit | Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase). {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP002578 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4503771 | RefSeq | NP_002018 | 379 | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
Identical Sequences to LMP002578 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4503771 | DBBJ | BAF84810.1 | 379 | unnamed protein product [Homo sapiens] |
| GI:4503771 | DBBJ | BAJ20660.1 | 379 | farnesyltransferase, CAAX box, alpha, partial [synthetic construct] |
| GI:4503771 | GenBank | AAX41892.1 | 379 | farnesyltransferase CAAX box alpha [synthetic construct] |
| GI:4503771 | GenBank | AIC48781.1 | 379 | FNTA, partial [synthetic construct] |
| GI:4503771 | PDB | 2F0Y | 379 | Chain A, Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate And Hydantoin Derivative |
| GI:4503771 | PDB | 3.00E+37 | 379 | Chain A, Protein Farnesyltransferase Complexed With Bisubstrate Ethylenediamine Scaffold Inhibitor 5 |
Related Sequences to LMP002578 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4503771 | GenBank | AAE22955.1 | 819 | Sequence 20 from patent US 5821118 |
| GI:4503771 | PDB | 1MZC | 382 | Chain A, Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate And Inhibitor Compound 33a |
| GI:4503771 | PDB | 1S63 | 382 | Chain A, Human Protein Farnesyltransferase Complexed With L-778,123 And Fpp |
| GI:4503771 | PDB | 1TN6 | 382 | Chain A, Protein Farnesyltransferase Complexed With A Rap2a Peptide Substrate And A Fpp Analog At 1.8a Resolution |
| GI:4503771 | PDB | 2H6F | 382 | Chain A, Protein Farnesyltransferase Complexed With A Farnesylated Ddptasacvls Peptide Product At 1.5a Resolution |
| GI:4503771 | PDB | 2IEJ | 382 | Chain A, Human Protein Farnesyltransferase Complexed With Inhibitor Compound Stn-48 And Fpp Analog At 1.8a Resolution |