Gene/Proteome Database (LMPD)

LMPD ID
LMP002580
Gene ID
2342
Species
Homo sapiens (Human)
Gene Name
farnesyltransferase, CAAX box, beta
Gene Symbol
FNTB
Synonyms
FPTB
Alternate Names
protein farnesyltransferase subunit beta; FTase-beta; CAAX farnesyltransferase subunit beta; ras proteins prenyltransferase subunit beta
Chromosome
14
Map Location
14q23.3
EC Number
2.5.1.58

Proteins

protein farnesyltransferase subunit beta
Refseq ID NP_002019
Protein GI 10835059
UniProt ID P49356
mRNA ID NM_002028
Length 437
RefSeq Status VALIDATED
MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD

Gene Information

Entrez Gene ID
2342
Gene Name
farnesyltransferase, CAAX box, beta
Gene Symbol
FNTB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005875 IDA:BHF-UCL C microtubule associated complex
GO:0005965 IDA:UniProtKB C protein farnesyltransferase complex
GO:0004311 IEA:Ensembl F farnesyltranstransferase activity
GO:0004660 IDA:UniProtKB F protein farnesyltransferase activity
GO:0008270 IDA:UniProtKB F zinc ion binding
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0045787 IEA:Ensembl P positive regulation of cell cycle
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0051770 IEA:Ensembl P positive regulation of nitric-oxide synthase biosynthetic process
GO:0018343 IDA:UniProtKB P protein farnesylation
GO:0022400 TAS:Reactome P regulation of rhodopsin mediated signaling pathway
GO:0034097 IEA:Ensembl P response to cytokine
GO:0010035 IEA:Ensembl P response to inorganic substance
GO:0014070 IEA:Ensembl P response to organic cyclic compound
GO:0016056 TAS:Reactome P rhodopsin mediated signaling pathway
GO:0042060 IEA:Ensembl P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
hsa00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_163919 Inactivation, recovery and regulation of the phototransduction cascade
REACT_163722 The phototransduction cascade
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR026872 Protein farnesyltransferase subunit beta
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
farnesyltransferase, CAAX box, beta
Protein Entry
FNTB_HUMAN
UniProt ID
P49356
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49356-1; Sequence=Displayed; Name=2; IsoId=P49356-2; Sequence=VSP_054657; Note=No experimental confirmation available.;
Catalytic Activity Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. {ECO
Cofactor Name=Zn(2+); Xref=ChEBI
Function Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO
Interaction P49354:FNTA; NbExp=7; IntAct=EBI-602349, EBI-602336;
Similarity Belongs to the protein prenyltransferase subunit beta family.
Similarity Contains 5 PFTB repeats.
Subunit Heterodimer of FNTA and FNTB. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002580 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10835059 RefSeq NP_002019 437 protein farnesyltransferase subunit beta

Identical Sequences to LMP002580 proteins

Reference Database Accession Length Protein Name
GI:10835059 GenBank JAA00636.1 437 farnesyltransferase, CAAX box, beta [Pan troglodytes]
GI:10835059 GenBank JAA13616.1 437 farnesyltransferase, CAAX box, beta [Pan troglodytes]
GI:10835059 GenBank JAA24047.1 437 farnesyltransferase, CAAX box, beta [Pan troglodytes]
GI:10835059 GenBank JAA38578.1 437 farnesyltransferase, CAAX box, beta [Pan troglodytes]
GI:10835059 GenBank AIC48782.1 437 FNTB, partial [synthetic construct]
GI:10835059 RefSeq XP_008976019.1 437 PREDICTED: protein farnesyltransferase subunit beta [Pan paniscus]

Related Sequences to LMP002580 proteins

Reference Database Accession Length Protein Name
GI:10835059 EMBL CAD62597.1 440 unnamed protein product, partial [Homo sapiens]
GI:10835059 GenBank AAE22955.1 819 Sequence 20 from patent US 5821118
GI:10835059 GenBank ACM85421.1 443 Sequence 10919 from patent US 6812339
GI:10835059 RefSeq XP_005561559.1 437 PREDICTED: protein farnesyltransferase subunit beta isoform X1 [Macaca fascicularis]
GI:10835059 RefSeq XP_007985176.1 437 PREDICTED: protein farnesyltransferase subunit beta [Chlorocebus sabaeus]
GI:10835059 RefSeq XP_010382020.1 437 PREDICTED: protein farnesyltransferase subunit beta [Rhinopithecus roxellana]