Gene/Proteome Database (LMPD)
LMPD ID
LMP002586
Gene ID
Species
Mus musculus (Mouse)
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Gene Symbol
Synonyms
1300002P16; mHS
Alternate Names
hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase
Chromosome
3
Map Location
3 F2.2|3 42.74 cM
EC Number
2.3.3.10
Proteins
| hydroxymethylglutaryl-CoA synthase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_032282 |
| Protein GI | 31560689 |
| UniProt ID | P54869 |
| mRNA ID | NM_008256 |
| Length | 508 |
| RefSeq Status | VALIDATED |
| MQRLLAPARRVLQVKRAMQETSLTPAHLLSAAQQRFSTIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARCPV | |
| transit_peptide: 1..37 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Probable); propagated from UniProtKB/Swiss-Prot (P54869.2) calculated_mol_wt: 4205 peptide sequence: MQRLLAPARRVLQVKRAMQETSLTPAHLLSAAQQRFS mat_peptide: 38..508 product: Hydroxymethylglutaryl-CoA synthase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P54869.2) calculated_mol_wt: 52636 peptide sequence: TIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARCPV | |
Gene Information
Entrez Gene ID
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005743 | IDA:MGI | C | mitochondrial inner membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0004421 | IEA:UniProtKB-EC | F | hydroxymethylglutaryl-CoA synthase activity |
| GO:0006695 | IEA:UniProtKB-KW | P | cholesterol biosynthetic process |
| GO:0008299 | IEA:InterPro | P | isoprenoid biosynthetic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR010122 | Hydroxymethylglutaryl-CoA synthase, eukaryotic |
| IPR013746 | Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain |
| IPR013528 | Hydroxymethylglutaryl-coenzyme A synthase, N-terminal |
| IPR000590 | Hydroxymethylglutaryl-coenzyme A synthase, active site |
| IPR016039 | Thiolase-like |
| IPR016038 | Thiolase-like, subgroup |
UniProt Annotations
Entry Information
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Protein Entry
HMCS2_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}. |
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. |
| Pathway | Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. |
| Ptm | Acetylation of Lys-427 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753}. |
| Similarity | Belongs to the HMG-CoA synthase family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion. |
| Subunit | Homodimer. {ECO:0000250}. |
| Tissue Specificity | Liver and kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002586 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31560689 | RefSeq | NP_032282 | 508 | hydroxymethylglutaryl-CoA synthase, mitochondrial precursor |
Identical Sequences to LMP002586 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31560689 | DBBJ | BAB23626.1 | 508 | unnamed protein product [Mus musculus] |
| GI:31560689 | GenBank | AAH14714.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [Mus musculus] |
| GI:31560689 | GenBank | AAH24744.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [Mus musculus] |
| GI:31560689 | GenBank | EDL38955.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Mus musculus] |
| GI:31560689 | GenBank | EDL38958.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Mus musculus] |
| GI:31560689 | SwissProt | P54869.2 | 508 | RecName: Full=Hydroxymethylglutaryl-CoA synthase, mitochondrial; Short=HMG-CoA synthase; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase; Flags: Precursor [Mus musculus] |
Related Sequences to LMP002586 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31560689 | DBBJ | BAB23657.1 | 508 | unnamed protein product [Mus musculus] |
| GI:31560689 | DBBJ | BAC05233.1 | 508 | unnamed protein product [Mus musculus] |
| GI:31560689 | GenBank | AAH83543.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) [Rattus norvegicus] |
| GI:31560689 | GenBank | EDL38956.1 | 524 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_b, partial [Mus musculus] |
| GI:31560689 | GenBank | EDL38957.1 | 524 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_b, partial [Mus musculus] |
| GI:31560689 | GenBank | EDL85567.1 | 508 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_a [Rattus norvegicus] |