Gene/Proteome Database (LMPD)

LMPD ID
LMP002598
Gene ID
67680
Species
Mus musculus (Mouse)
Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbol
Sdhb
Synonyms
0710008N11Rik
Alternate Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; ip; iron-sulfur subunit of complex II; succinate dehydrogenase complex subunit B
Chromosome
4
Map Location
4|4 E1
EC Number
1.3.5.1

Proteins

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Refseq ID NP_075863
Protein GI 34328286
UniProt ID Q9CQA3
mRNA ID NM_023374
Length 282
RefSeq Status PROVISIONAL
MAATVGVSLKRGFPAAVLGRVGLQFQACRGAQTAAAAAPRIKKFAIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA
transit_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9CQA3.1) calculated_mol_wt: 3062 peptide sequence: MAATVGVSLKRGFPAAVLGRVGLQFQACRG mat_peptide: 31..282 product: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9CQA3.1) calculated_mol_wt: 28770 peptide sequence: AQTAAAAAPRIKKFAIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA

Gene Information

Entrez Gene ID
67680
Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbol
Sdhb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0005749 ISS:UniProtKB C mitochondrial respiratory chain complex II
GO:0005739 IDA:MGI C mitochondrion
GO:0045273 IDA:MGI C respiratory chain complex II
GO:0051537 ISS:UniProtKB F 2 iron, 2 sulfur cluster binding
GO:0051538 ISS:UniProtKB F 3 iron, 4 sulfur cluster binding
GO:0051539 ISS:UniProtKB F 4 iron, 4 sulfur cluster binding
GO:0009055 IEA:InterPro F electron carrier activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0008177 IEA:UniProtKB-EC F succinate dehydrogenase (ubiquinone) activity
GO:0048039 ISS:UniProtKB F ubiquinone binding
GO:0022904 IEA:Ensembl P respiratory electron transport chain
GO:0006105 IEA:Ensembl P succinate metabolic process
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
mmu05010 Alzheimer's disease
mmu05016 Huntington's disease
mmu04932 Non-alcoholic fatty liver disease (NAFLD)
mmu05012 Parkinson's disease

Domain Information

InterPro Annotations

Accession Description
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
IPR001041 2Fe-2S ferredoxin-type domain
IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
IPR009051 Alpha-helical ferredoxin
IPR012675 Beta-grasp domain
IPR025192 Succinate dehydogenase/fumarate reductase N-terminal
IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein

UniProt Annotations

Entry Information

Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Protein Entry
SDHB_MOUSE
UniProt ID
Q9CQA3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Succinate + a quinone = fumarate + a quinol.
Cofactor Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000250}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
Cofactor Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000250}; Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
Cofactor Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
Function Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Similarity Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO:0000305}.
Similarity Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
Similarity Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00711}.
Subcellular Location Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Subunit Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002598 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
34328286 RefSeq NP_075863 282 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

Identical Sequences to LMP002598 proteins

Reference Database Accession Length Protein Name
GI:34328286 DBBJ BAE41016.1 282 unnamed protein product [Mus musculus]
GI:34328286 DBBJ BAE31674.1 282 unnamed protein product [Mus musculus]
GI:34328286 GenBank AAH13509.1 282 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Mus musculus]
GI:34328286 GenBank AAH51934.1 282 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Mus musculus]
GI:34328286 GenBank EDL13336.1 282 succinate dehydrogenase complex, subunit B, iron sulfur (Ip), isoform CRA_f [Mus musculus]
GI:34328286 SwissProt Q9CQA3.1 282 RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; AltName: Full=Iron-sulfur subunit of complex II; Short=Ip; Flags: Precursor [Mus musculus]

Related Sequences to LMP002598 proteins

Reference Database Accession Length Protein Name
GI:34328286 DBBJ BAB22534.1 282 unnamed protein product [Mus musculus]
GI:34328286 DBBJ BAE41403.1 282 unnamed protein product [Mus musculus]
GI:34328286 GenBank EDL13335.1 280 succinate dehydrogenase complex, subunit B, iron sulfur (Ip), isoform CRA_e [Mus musculus]
GI:34328286 RefSeq XP_005081132.1 282 PREDICTED: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [Mesocricetus auratus]
GI:34328286 RefSeq XP_005352976.1 282 PREDICTED: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [Microtus ochrogaster]
GI:34328286 RefSeq XP_006539191.1 280 PREDICTED: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [Mus musculus]