Gene/Proteome Database (LMPD)

LMPD ID
LMP002617
Gene ID
5295
Species
Homo sapiens (Human)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene Symbol
PIK3R1
Synonyms
AGM7; GRB1; IMD36; p85; p85-ALPHA
Alternate Names
phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase regulatory subunit; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Chromosome
5
Map Location
5q13.1
Summary
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Orthologs
View orthologs and multiple alignments for PIK3R1

Proteins

phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
Refseq ID NP_852664
Protein GI 32455248
UniProt ID P27986
mRNA ID NM_181523
Length 724
RefSeq Status REVIEWED
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2
Refseq ID NP_852556
Protein GI 32455252
UniProt ID P27986
mRNA ID NM_181504
Length 454
RefSeq Status REVIEWED
MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3
Refseq ID NP_852665
Protein GI 32455250
UniProt ID P27986
mRNA ID NM_181524
Length 424
RefSeq Status REVIEWED
MHNLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4
Refseq ID NP_001229395
Protein GI 335057534
UniProt ID P27986
mRNA ID NM_001242466
Length 361
RefSeq Status REVIEWED
MHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR

Gene Information

Entrez Gene ID
5295
Gene Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene Symbol
PIK3R1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005911 IEA:Ensembl C cell-cell junction
GO:0005829 TAS:Reactome C cytosol
GO:0016020 IDA:UniProtKB C membrane
GO:0005942 ISS:BHF-UCL C phosphatidylinositol 3-kinase complex
GO:0005943 ISS:UniProtKB C phosphatidylinositol 3-kinase complex, class IA
GO:0005886 TAS:Reactome C plasma membrane
GO:0043125 IDA:UniProtKB F ErbB-3 class receptor binding
GO:0043559 IDA:UniProtKB F insulin binding
GO:0005158 IPI:UniProtKB F insulin receptor binding
GO:0043560 ISS:BHF-UCL F insulin receptor substrate binding
GO:0005159 IPI:UniProtKB F insulin-like growth factor receptor binding
GO:0005168 IPI:UniProtKB F neurotrophin TRKA receptor binding
GO:0043548 ISS:BHF-UCL F phosphatidylinositol 3-kinase binding
GO:0035014 ISS:UniProtKB F phosphatidylinositol 3-kinase regulator activity
GO:0019903 IPI:UniProtKB F protein phosphatase binding
GO:0005068 ISS:BHF-UCL F transmembrane receptor protein tyrosine kinase adaptor activity
GO:0030183 IEA:Ensembl P B cell differentiation
GO:0038095 TAS:Reactome P Fc-epsilon receptor signaling pathway
GO:0038096 TAS:Reactome P Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0051531 IEA:Ensembl P NFAT protein import into nucleus
GO:0031295 TAS:Reactome P T cell costimulation
GO:0050852 TAS:Reactome P T cell receptor signaling pathway
GO:0007596 TAS:Reactome P blood coagulation
GO:0034644 IEA:Ensembl P cellular response to UV
GO:0007173 TAS:Reactome P epidermal growth factor receptor signaling pathway
GO:0008625 IEA:Ensembl P extrinsic apoptotic signaling pathway via death domain receptors
GO:0008543 TAS:Reactome P fibroblast growth factor receptor signaling pathway
GO:0060396 IDA:BHF-UCL P growth hormone receptor signaling pathway
GO:0045087 TAS:Reactome P innate immune response
GO:0008286 TAS:Reactome P insulin receptor signaling pathway
GO:0048009 IPI:UniProtKB P insulin-like growth factor receptor signaling pathway
GO:0008630 IEA:Ensembl P intrinsic apoptotic signaling pathway in response to DNA damage
GO:0050900 TAS:Reactome P leukocyte migration
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0001953 IEA:Ensembl P negative regulation of cell-matrix adhesion
GO:0045671 IEA:Ensembl P negative regulation of osteoclast differentiation
GO:0048011 TAS:Reactome P neurotrophin TRK receptor signaling pathway
GO:0014065 IDA:BHF-UCL P phosphatidylinositol 3-kinase signaling
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0046854 ISS:UniProtKB P phosphatidylinositol phosphorylation
GO:0048015 TAS:Reactome P phosphatidylinositol-mediated signaling
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0030168 TAS:Reactome P platelet activation
GO:0030335 IEA:Ensembl P positive regulation of cell migration
GO:0090004 ISS:BHF-UCL P positive regulation of establishment of protein localization to plasma membrane
GO:0046326 ISS:BHF-UCL P positive regulation of glucose import
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0032760 IEA:Ensembl P positive regulation of tumor necrosis factor production
GO:0006468 IEA:Ensembl P protein phosphorylation
GO:0043551 ISS:BHF-UCL P regulation of phosphatidylinositol 3-kinase activity
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0016032 IEA:UniProtKB-KW P viral process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04024 cAMP signaling pathway
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3_domain
IPR011511 Variant SH3 domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Protein Entry
P85A_HUMAN
UniProt ID
P27986
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P27986-1; Sequence=Displayed; Name=2; Synonyms=AS53; IsoId=P27986-2; Sequence=VSP_021842, VSP_021843; Name=3; Synonyms=p46; IsoId=P27986-3; Sequence=VSP_021841, VSP_021844; Name=4; Synonyms=p85I; IsoId=P27986-4; Sequence=VSP_021845; Name=5; IsoId=P27986-5; Sequence=VSP_045903; Note=No experimental confirmation available.;
Disease Agammaglobulinemia 7, autosomal recessive (AGM7) [MIM
Disease SHORT syndrome (SHORTS) [MIM
Domain The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. {ECO
Interaction Q8IZP0:ABI1; NbExp=8; IntAct=EBI-79464, EBI-375446; P42684:ABL2; NbExp=2; IntAct=EBI-79464, EBI-1102694; P10275:AR; NbExp=5; IntAct=EBI-79464, EBI-608057; P22681:CBL; NbExp=5; IntAct=EBI-79464, EBI-518228; P10747:CD28; NbExp=8; IntAct=EBI-79464, EBI-4314301; Q8IY22:CMIP; NbExp=2; IntAct=EBI-79464, EBI-7689652; P46108:CRK; NbExp=2; IntAct=EBI-79464, EBI-886; P46109:CRKL; NbExp=2; IntAct=EBI-79464, EBI-910; P16410:CTLA4; NbExp=3; IntAct=EBI-79464, EBI-1030991; Q9Y2H0:DLGAP4; NbExp=2; IntAct=EBI-79464, EBI-722139; P00533:EGFR; NbExp=5; IntAct=EBI-79464, EBI-297353; P04626:ERBB2; NbExp=11; IntAct=EBI-79464, EBI-641062; P21860:ERBB3; NbExp=40; IntAct=EBI-79464, EBI-720706; P03372:ESR1; NbExp=6; IntAct=EBI-79464, EBI-78473; P48023:FASLG; NbExp=2; IntAct=EBI-79464, EBI-495538; P11362:FGFR1; NbExp=5; IntAct=EBI-79464, EBI-1028277; P17948:FLT1; NbExp=2; IntAct=EBI-79464, EBI-1026718; P36888:FLT3; NbExp=2; IntAct=EBI-79464, EBI-3946257; Q13480:GAB1; NbExp=33; IntAct=EBI-79464, EBI-517684; P62993:GRB2; NbExp=3; IntAct=EBI-79464, EBI-401755; P42858:HTT; NbExp=7; IntAct=EBI-79464, EBI-466029; P08069:IGF1R; NbExp=4; IntAct=EBI-79464, EBI-475981; P06213:INSR; NbExp=3; IntAct=EBI-79464, EBI-475899; P35568:IRS1; NbExp=12; IntAct=EBI-79464, EBI-517592; P35570:Irs1 (xeno); NbExp=2; IntAct=EBI-79464, EBI-520230; Q9Y4H2:IRS2; NbExp=2; IntAct=EBI-79464, EBI-1049582; P10721:KIT; NbExp=19; IntAct=EBI-79464, EBI-1379503; Q86VI4-3:LAPTM4B; NbExp=2; IntAct=EBI-79464, EBI-3267286; O43561:LAT; NbExp=4; IntAct=EBI-79464, EBI-1222766; Q92918:MAP4K1; NbExp=2; IntAct=EBI-79464, EBI-881; P45983:MAPK8; NbExp=2; IntAct=EBI-79464, EBI-286483; P08581:MET; NbExp=6; IntAct=EBI-79464, EBI-1039152; Q8WX92:NELFB; NbExp=2; IntAct=EBI-79464, EBI-347721; Q6PFX7:Nyap1 (xeno); NbExp=4; IntAct=EBI-79464, EBI-7447489; Q8BM65-4:Nyap2 (xeno); NbExp=3; IntAct=EBI-79464, EBI-7447598; P09619:PDGFRB; NbExp=19; IntAct=EBI-79464, EBI-641237; P42336:PIK3CA; NbExp=13; IntAct=EBI-79464, EBI-2116585; P16885:PLCG2; NbExp=2; IntAct=EBI-79464, EBI-617403; P49023:PXN; NbExp=2; IntAct=EBI-79464, EBI-702209; Q13905:RAPGEF1; NbExp=2; IntAct=EBI-79464, EBI-976876; P26373:RPL13; NbExp=2; IntAct=EBI-79464, EBI-356849; P19793:RXRA; NbExp=8; IntAct=EBI-79464, EBI-78598; Q9UPX8:SHANK2; NbExp=2; IntAct=EBI-79464, EBI-1570571; P29353:SHC1; NbExp=3; IntAct=EBI-79464, EBI-78835; Q96EB6:SIRT1; NbExp=3; IntAct=EBI-79464, EBI-1802965; Q07889:SOS1; NbExp=3; IntAct=EBI-79464, EBI-297487; P12931:SRC; NbExp=6; IntAct=EBI-79464, EBI-621482; P30874:SSTR2; NbExp=5; IntAct=EBI-79464, EBI-6266898; P58753:TIRAP; NbExp=3; IntAct=EBI-79464, EBI-528644; O15455:TLR3; NbExp=2; IntAct=EBI-79464, EBI-6116630; Q15661:TPSAB1; NbExp=2; IntAct=EBI-79464, EBI-1761369; Q9ULW0:TPX2; NbExp=2; IntAct=EBI-79464, EBI-1037322; Q9UKW4:VAV3; NbExp=2; IntAct=EBI-79464, EBI-297568; Q99152:VP3 (xeno); NbExp=3; IntAct=EBI-79464, EBI-1776808; Q8IUH5:ZDHHC17; NbExp=2; IntAct=EBI-9090282, EBI-524753;
Ptm Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR. {ECO
Ptm Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation. {ECO
Similarity Belongs to the PI3K p85 subunit family.
Similarity Contains 1 Rho-GAP domain. {ECO
Similarity Contains 1 SH3 domain. {ECO
Similarity Contains 2 SH2 domains. {ECO
Subunit Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with FER. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and HCST. Interacts with FASLG, KIT and BCR. Interacts with AXL, FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with FGR and HCK. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts with NTRK1 (phosphorylated upon ligand-binding). {ECO
Tissue Specificity Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PIK3R1ID41717ch5q13.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP002617 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32455248 RefSeq NP_852664 724 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
32455252 RefSeq NP_852556 454 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2
32455250 RefSeq NP_852665 424 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3
335057534 RefSeq NP_001229395 361 phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4

Identical Sequences to LMP002617 proteins

Reference Database Accession Length Protein Name
GI:32455250 GenBank AAO15359.1 424 phosphoinositide 3-kinase p85 subunit splicing variant p46 [Homo sapiens]
GI:32455248 GenBank EAW51313.1 724 phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha), isoform CRA_b [Homo sapiens]
GI:32455248 GenBank ADS18221.1 724 Sequence 78 from patent US 7763418
GI:32455252 GenBank AEW40348.1 454 Sequence 218 from patent US 8071291
GI:32455248 GenBank AEW40349.1 724 Sequence 219 from patent US 8071291
GI:32455250 GenBank AEW40350.1 424 Sequence 220 from patent US 8071291
GI:32455248 GenBank AFN91702.1 724 Sequence 2 from patent US 8198252
GI:32455252 GenBank AFN91703.1 454 Sequence 4 from patent US 8198252
GI:32455250 GenBank AFN91704.1 424 Sequence 5 from patent US 8198252
GI:32455252 GenBank AHD71039.1 454 Sequence 4507 from patent US 8586006
GI:32455248 GenBank AHD71040.1 724 Sequence 4508 from patent US 8586006
GI:32455250 GenBank AHD71041.1 424 Sequence 4509 from patent US 8586006
GI:32455248 RefSeq XP_005248599.1 724 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [Homo sapiens]

Related Sequences to LMP002617 proteins

Reference Database Accession Length Protein Name
GI:335057534 EMBL CAB69305.1 970 unnamed protein product [unidentified]
GI:335057534 EMBL CAD35716.1 970 unnamed protein product [unidentified]
GI:335057534 EMBL CAD90932.1 724 unnamed protein product [Homo sapiens]
GI:335057534 GenBank AAP00277.1 970 Sequence 67 from patent US 6518021
GI:335057534 GenBank AEU47769.1 970 Sequence 67 from patent US 8058008
GI:335057534 GenBank AEW40350.1 424 Sequence 220 from patent US 8071291
GI:32455248 GenBank JAA08862.1 724 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Pan troglodytes]
GI:32455248 GenBank JAA17766.1 724 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Pan troglodytes]
GI:32455248 GenBank JAA28066.1 724 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Pan troglodytes]
GI:32455248 RefSeq XP_003806841.1 724 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [Pan paniscus]
GI:32455252 RefSeq XP_004058804.1 454 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 [Gorilla gorilla gorilla]
GI:32455250 RefSeq XP_004058806.1 424 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3 [Gorilla gorilla gorilla]
GI:32455252 RefSeq XP_004862898.1 454 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X4 [Heterocephalus glaber]
GI:32455250 RefSeq XP_004862899.1 424 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X5 [Heterocephalus glaber]
GI:32455252 RefSeq XP_007972578.1 454 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [Chlorocebus sabaeus]
GI:32455250 RefSeq XP_007972586.1 424 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [Chlorocebus sabaeus]
GI:32455252 RefSeq XP_008058349.1 454 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [Tarsius syrichta]
GI:32455252 RefSeq XP_008591101.1 454 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [Galeopterus variegatus]
GI:32455250 RefSeq XP_008591103.1 424 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [Galeopterus variegatus]
GI:32455248 RefSeq XP_008955738.1 724 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [Pan paniscus]
GI:32455250 RefSeq XP_008955753.1 424 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [Pan paniscus]
GI:32455248 RefSeq XP_009447342.1 724 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [Pan troglodytes]
GI:32455250 RefSeq XP_010378508.1 424 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [Rhinopithecus roxellana]
GI:32455252 RefSeq XP_010378509.1 454 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [Rhinopithecus roxellana]