Gene/Proteome Database (LMPD)

LMPD ID
LMP002619
Gene ID
3707
Species
Homo sapiens (Human)
Gene Name
inositol-trisphosphate 3-kinase B
Gene Symbol
ITPKB
Synonyms
IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37
Chromosome
1
Map Location
1q42.13
Summary
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ITPKB

Proteins

inositol-trisphosphate 3-kinase B
Refseq ID NP_002212
Protein GI 194272161
UniProt ID P27987
mRNA ID NM_002221
Length 946
RefSeq Status REVIEWED
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEMSQDAPLA

Gene Information

Entrez Gene ID
3707
Gene Name
inositol-trisphosphate 3-kinase B
Gene Symbol
ITPKB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa04020 Calcium signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150312 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol-trisphosphate 3-kinase B
Protein Entry
IP3KB_HUMAN
UniProt ID
P27987
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002619 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
194272161 RefSeq NP_002212 946 inositol-trisphosphate 3-kinase B

Identical Sequences to LMP002619 proteins

Reference Database Accession Length Protein Name
GI:194272161 GenBank AED82369.1 946 Sequence 1106 from patent US 7919467
GI:194272161 SwissProt P27987.5 946 RecName: Full=Inositol-trisphosphate 3-kinase B; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase B; Short=IP3 3-kinase B; Short=IP3K B; Short=InsP 3-kinase B [Homo sapiens]

Related Sequences to LMP002619 proteins

Reference Database Accession Length Protein Name
GI:194272161 EMBL CAC40650.1 946 inositol 1,4,5-trisphosphate 3-kinase, isoform B [Homo sapiens]
GI:194272161 EMBL CAB65055.3 946 inositol 1,4,5-trisphosphate 3-kinase B [Homo sapiens]
GI:194272161 GenBank EAW69793.1 946 inositol 1,4,5-trisphosphate 3-kinase B [Homo sapiens]
GI:194272161 GenBank JAA26650.1 946 inositol-trisphosphate 3-kinase B [Pan troglodytes]
GI:194272161 GenBank JAA34517.1 946 inositol-trisphosphate 3-kinase B [Pan troglodytes]
GI:194272161 RefSeq XP_003814977.1 946 PREDICTED: inositol-trisphosphate 3-kinase B [Pan paniscus]