Gene/Proteome Database (LMPD)
LMPD ID
LMP002647
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA binding domain containing 3
Gene Symbol
Synonyms
GCP60; GOCAP1; GOLPH1; PAP7
Alternate Names
Golgi resident protein GCP60; golgi phosphoprotein 1; PKA (RIalpha)-associated protein; PBR- and PKA-associated protein 7; golgi complex associated protein 1, 60kDa; acyl-Coenzyme A binding domain containing 3; peripheral benzodiazepine receptor-associated protein PAP7
Chromosome
1
Map Location
1q42.12
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| Golgi resident protein GCP60 | |
|---|---|
| Refseq ID | NP_073572 |
| Protein GI | 15826852 |
| UniProt ID | Q9H3P7 |
| mRNA ID | NM_022735 |
| Length | 528 |
| RefSeq Status | REVIEWED |
| MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEPGEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLKLVALHKQVLMGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR | |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA binding domain containing 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:HPA | C | Golgi apparatus |
| GO:0016021 | IEA:InterPro | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0000062 | IEA:InterPro | F | fatty-acyl-CoA binding |
| GO:0006694 | IEA:UniProtKB-KW | P | steroid biosynthetic process |
| GO:0006810 | IEA:InterPro | P | transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
acyl-CoA binding domain containing 3
Protein Entry
GCP60_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Domain | The GOLD domain is essential for giantin binding. |
| Function | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). |
| Interaction | O91464:- (xeno); NbExp=21; IntAct=EBI-1791792, EBI-7587528; Q9UBF8:PI4KB; NbExp=4; IntAct=EBI-1791792, EBI-1053214; Q8BHN0:Ppm1l (xeno); NbExp=3; IntAct=EBI-1791792, EBI-7970002; |
| Similarity | Contains 1 ACB (acyl-CoA-binding) domain. |
| Similarity | Contains 1 GOLD domain. {ECO |
| Subcellular Location | Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side {ECO |
| Subunit | Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1. Interacts with PBR and PKA regulatory subunit RI- alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity). |
| Tissue Specificity | Ubiquitous, with highest expression in testis and ovary. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002647 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15826852 | RefSeq | NP_073572 | 528 | Golgi resident protein GCP60 |
Identical Sequences to LMP002647 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15826852 | DBBJ | BAB20592.2 | 528 | golgi resident protein GCP60 [Homo sapiens] |
| GI:15826852 | DBBJ | BAG37076.1 | 528 | unnamed protein product [Homo sapiens] |
| GI:15826852 | GenBank | AAH45533.1 | 528 | Acyl-Coenzyme A binding domain containing 3 [Homo sapiens] |
| GI:15826852 | GenBank | EAW69775.1 | 528 | acyl-Coenzyme A binding domain containing 3, isoform CRA_a [Homo sapiens] |
| GI:15826852 | GenBank | EAW69776.1 | 528 | acyl-Coenzyme A binding domain containing 3, isoform CRA_a [Homo sapiens] |
| GI:15826852 | SwissProt | Q9H3P7.4 | 528 | RecName: Full=Golgi resident protein GCP60; AltName: Full=Acyl-CoA-binding domain-containing protein 3; AltName: Full=Golgi complex-associated protein 1; Short=GOCAP1; AltName: Full=Golgi phosphoprotein 1; Short=GOLPH1; AltName: Full=PBR- and PKA-associated protein 7; AltName: Full=Peripheral benzodiazepine receptor-associated protein PAP7 [Homo sapiens] |
Related Sequences to LMP002647 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15826852 | DBBJ | BAB15159.1 | 528 | unnamed protein product [Homo sapiens] |
| GI:15826852 | GenBank | AAH60792.1 | 528 | ACBD3 protein [Homo sapiens] |
| GI:15826852 | GenBank | JAA11025.1 | 528 | acyl-CoA binding domain containing 3 [Pan troglodytes] |
| GI:15826852 | GenBank | JAA13101.1 | 528 | acyl-CoA binding domain containing 3 [Pan troglodytes] |
| GI:15826852 | GenBank | JAA30682.1 | 528 | acyl-CoA binding domain containing 3 [Pan troglodytes] |
| GI:15826852 | RefSeq | XP_001140648.1 | 528 | PREDICTED: Golgi resident protein GCP60 [Pan troglodytes] |