Gene/Proteome Database (LMPD)

LMPD ID
LMP002668
Gene ID
10891
Species
Homo sapiens (Human)
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene Symbol
PPARGC1A
Synonyms
LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1
Alternate Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; L-PGC-1alpha; PPARGC-1-alpha; ligand effect modulator-6; PPAR gamma coactivator variant form; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext
Chromosome
4
Map Location
4p15.1
Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PPARGC1A

Proteins

peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Refseq ID NP_037393
Protein GI 7019499
UniProt ID Q9UBK2
mRNA ID NM_013261
Length 798
RefSeq Status REVIEWED
MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR

Gene Information

Entrez Gene ID
10891
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene Symbol
PPARGC1A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005665 TAS:UniProtKB C DNA-directed RNA polymerase II, core complex
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:UniProtKB C nucleus
GO:0050681 NAS:UniProtKB F androgen receptor binding
GO:0031490 ISS:UniProtKB F chromatin DNA binding
GO:0003677 ISS:UniProtKB F DNA binding
GO:0016922 IPI:UniProtKB F ligand-dependent nuclear receptor binding
GO:0030374 IDA:BHF-UCL F ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0003723 TAS:UniProtKB F RNA binding
GO:0001104 TAS:UniProtKB F RNA polymerase II transcription cofactor activity
GO:0043565 IDA:UniProtKB F sequence-specific DNA binding
GO:0003713 IDA:UniProtKB F transcription coactivator activity
GO:0008134 TAS:UniProtKB F transcription factor binding
GO:0031625 IPI:UniProtKB F ubiquitin protein ligase binding
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0030521 NAS:UniProtKB P androgen receptor signaling pathway
GO:0050873 TAS:UniProtKB P brown fat cell differentiation
GO:0001678 NAS:UniProtKB P cellular glucose homeostasis
GO:0045333 TAS:UniProtKB P cellular respiration
GO:0071398 IEA:Ensembl P cellular response to fatty acid
GO:0071456 IEA:Ensembl P cellular response to hypoxia
GO:0071250 IEA:Ensembl P cellular response to nitrite
GO:0034599 ISS:UniProtKB P cellular response to oxidative stress
GO:0097067 IEA:Ensembl P cellular response to thyroid hormone stimulus
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0032922 ISS:UniProtKB P circadian regulation of gene expression
GO:0007586 TAS:UniProtKB P digestion
GO:0019395 NAS:UniProtKB P fatty acid oxidation
GO:0051552 IEA:Ensembl P flavone metabolic process
GO:0006012 IEA:Ensembl P galactose metabolic process
GO:0006094 NAS:UniProtKB P gluconeogenesis
GO:0007005 NAS:UniProtKB P mitochondrion organization
GO:0006397 TAS:UniProtKB P mRNA processing
GO:0045820 IEA:Ensembl P negative regulation of glycolytic process
GO:0043524 ISS:UniProtKB P negative regulation of neuron apoptotic process
GO:1901215 IGI:UniProtKB P negative regulation of neuron death
GO:2000272 IEA:Ensembl P negative regulation of receptor activity
GO:2001171 ISS:UniProtKB P positive regulation of ATP biosynthetic process
GO:1901857 IEA:Ensembl P positive regulation of cellular respiration
GO:2000507 ISS:UniProtKB P positive regulation of energy homeostasis
GO:0046321 TAS:UniProtKB P positive regulation of fatty acid oxidation
GO:0045722 TAS:UniProtKB P positive regulation of gluconeogenesis
GO:0035066 TAS:UniProtKB P positive regulation of histone acetylation
GO:1901860 IEA:Ensembl P positive regulation of mitochondrial DNA metabolic process
GO:0010822 ISS:UniProtKB P positive regulation of mitochondrion organization
GO:1901863 IEA:Ensembl P positive regulation of muscle tissue development
GO:0051091 IDA:BHF-UCL P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661 IEA:Ensembl P positive regulation of smooth muscle cell proliferation
GO:0045893 NAS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0045944 IDA:ParkinsonsUK-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0006461 TAS:UniProtKB P protein complex assembly
GO:0050821 TAS:UniProtKB P protein stabilization
GO:0042752 ISS:UniProtKB P regulation of circadian rhythm
GO:2000310 IEA:Ensembl P regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0006355 IDA:UniProtKB P regulation of transcription, DNA-templated
GO:0022904 ISS:UniProtKB P respiratory electron transport chain
GO:0009409 IEA:Ensembl P response to cold
GO:0071871 IEA:Ensembl P response to epinephrine
GO:0043201 IEA:Ensembl P response to leucine
GO:0014850 ISS:BHF-UCL P response to muscle activity
GO:0071873 IEA:Ensembl P response to norepinephrine
GO:0042594 NAS:UniProtKB P response to starvation
GO:0036273 IEA:Ensembl P response to statin
GO:0008380 TAS:UniProtKB P RNA splicing
GO:0001659 TAS:UniProtKB P temperature homeostasis
GO:0006367 TAS:UniProtKB P transcription initiation from RNA polymerase II promoter

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Protein Entry
PRGC1_HUMAN
UniProt ID
Q9UBK2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative promoter usage, Alternative splicing; Named isoforms=9; Name=1; IsoId=Q9UBK2-1; Sequence=Displayed; Name=NT-7a; IsoId=Q9UBK2-2; Sequence=VSP_047684, VSP_047685; Name=B5; IsoId=Q9UBK2-3; Sequence=VSP_053724; Note=Produced by alternative promoter usage.; Name=B4; IsoId=Q9UBK2-4; Sequence=VSP_053725; Note=Produced by alternative promoter usage.; Name=B4-8a; IsoId=Q9UBK2-5; Sequence=VSP_053725, VSP_053728, VSP_053729; Note=Produced by alternative promoter usage.; Name=B5-NT; IsoId=Q9UBK2-6; Sequence=VSP_053724, VSP_047684, VSP_047685; Note=Produced by alternative promoter usage.; Name=B4-3ext; IsoId=Q9UBK2-7; Sequence=VSP_053725, VSP_053726, VSP_053727; Note=Produced by alternative promoter usage.; Name=8a; IsoId=Q9UBK2-8; Sequence=VSP_053728, VSP_053729; Name=9; Synonyms=L-PGG-1alpha; IsoId=Q9UBK2-9; Sequence=VSP_053770; Note=Produced by alternative promoter usage. May be involved in gluconeogenesis, liver-specific.;
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. {ECO
Induction Transcription is repressed by ZNF746 which binds to 'insulin response sequences' its promoter.
Interaction P62508:ESRRG; NbExp=3; IntAct=EBI-765486, EBI-2834260; P42704:LRPPRC; NbExp=2; IntAct=EBI-765486, EBI-1050853;
Ptm Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Ptm Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
Ptm Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.
Similarity Contains 1 RRM (RNA recognition motif) domain.
Subcellular Location Isoform 1: Nucleus. Nucleus, PML body.
Subcellular Location Isoform 9: Nucleus .
Subcellular Location Isoform B4-8a: Cytoplasm. Nucleus.
Subcellular Location Isoform B4: Nucleus.
Subcellular Location Isoform B5: Nucleus. Nucleus, PML body.
Subunit Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity). Interacts with PRDM16, LPIN1 and PML (By similarity). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger). {ECO
Tissue Specificity Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. {ECO
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ppargc1a/";

Identical and Related Proteins

Unique RefSeq proteins for LMP002668 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7019499 RefSeq NP_037393 798 peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Identical Sequences to LMP002668 proteins

Reference Database Accession Length Protein Name
GI:7019499 GenBank AAI56324.1 798 Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, partial [synthetic construct]
GI:7019499 GenBank ADF24550.1 798 Sequence 2451 from patent US 7691569
GI:7019499 GenBank ADF24840.1 798 Sequence 5 from patent US 7691578
GI:7019499 GenBank AED17333.1 798 Sequence 2451 from patent US 7879556
GI:7019499 GenBank AED47660.1 798 Sequence 2451 from patent US 7892745
GI:7019499 GenBank AEH98540.1 798 Sequence 2 from patent US 7947652

Related Sequences to LMP002668 proteins

Reference Database Accession Length Protein Name
GI:7019499 EMBL CAK22378.1 798 unnamed protein product [Homo sapiens]
GI:7019499 GenBank AAD51615.1 798 PPAR gamma coactivator-1 [Homo sapiens]
GI:7019499 GenBank AAN25918.1 798 Sequence 5 from patent US 6426411
GI:7019499 GenBank AAY06844.1 798 Sequence 5 from patent US 6872391
GI:7019499 GenBank ABA09184.1 798 Sequence 5 from patent US 6908987
GI:7019499 GenBank ACE26974.1 798 Sequence 5 from patent US 7371529