Gene/Proteome Database (LMPD)

LMPD ID
LMP002674
Gene ID
1632
Species
Homo sapiens (Human)
Gene Name
enoyl-CoA delta isomerase 1
Gene Symbol
ECI1
Synonyms
DCI
Alternate Names
enoyl-CoA delta isomerase 1, mitochondrial; dodecenoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; acetylene-allene isomerase; 3,2 trans-enoyl-CoA isomerase; delta3, delta2-enoyl-CoA isomerase; 3,2 trans-enoyl-Coenzyme A isomerase; delta(3),Delta(2)-enoyl-CoA isomerase; 3,2-trans-enoyl-CoA isomerase, mitochondrial; dodecenoyl-CoA delta isomerase (3,2 trans-enoyl-CoA isomerase); dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase)
Chromosome
16
Map Location
16p13.3
EC Number
5.3.3.8
Summary
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
Orthologs
View orthologs and multiple alignments for ECI1

Proteins

enoyl-CoA delta isomerase 1, mitochondrial isoform 1 precursor
Refseq ID NP_001910
Protein GI 62530384
UniProt ID P42126
mRNA ID NM_001919
Length 302
RefSeq Status REVIEWED
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG
transit_peptide: 1..41 calculated_mol_wt: 4098 peptide sequence: MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARR mat_peptide: 42..285 product: enoyl-CoA delta isomerase 1, mitochondrial isoform 2 calculated_mol_wt: 26816 peptide sequence: FGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG transit_peptide: 1..41 calculated_mol_wt: 4098 peptide sequence: MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARR mat_peptide: 42..302 product: enoyl-CoA delta isomerase 1, mitochondrial isoform 1 calculated_mol_wt: 28736 peptide sequence: FGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG
enoyl-CoA delta isomerase 1, mitochondrial isoform 2 precursor
Refseq ID NP_001171500
Protein GI 295842266
UniProt ID P42126
mRNA ID NM_001178029
Length 285
RefSeq Status REVIEWED
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG

Gene Information

Entrez Gene ID
1632
Gene Name
enoyl-CoA delta isomerase 1
Gene Symbol
ECI1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005743 IEA:Ensembl C mitochondrial inner membrane
GO:0005759 NAS:UniProtKB C mitochondrial matrix
GO:0005739 IDA:UniProt C mitochondrion
GO:0004165 NAS:UniProtKB F dodecenoyl-CoA delta-isomerase activity
GO:0016860 TAS:Reactome F intramolecular oxidoreductase activity
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0006635 NAS:UniProtKB P fatty acid beta-oxidation
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00071 Fatty acid degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
FAO-PWY fatty acid beta-oxidation I

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
enoyl-CoA delta isomerase 1
Protein Entry
ECI1_HUMAN
UniProt ID
P42126
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P42126-1; Sequence=Displayed; Name=2; IsoId=P42126-2; Sequence=VSP_001358; Note=No experimental confirmation available.;
Catalytic Activity (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family.
Subcellular Location Mitochondrion matrix.
Subunit Homotrimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP002674 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62530384 RefSeq NP_001910 302 enoyl-CoA delta isomerase 1, mitochondrial isoform 1 precursor
295842266 RefSeq NP_001171500 285 enoyl-CoA delta isomerase 1, mitochondrial isoform 2 precursor

Identical Sequences to LMP002674 proteins

Reference Database Accession Length Protein Name
GI:62530384 DBBJ BAJ20726.1 302 dodecenoyl-Coenzyme A delta isomerase, partial [synthetic construct]
GI:295842266 GenBank AAH02746.1 285 DCI protein [Homo sapiens]
GI:295842266 GenBank AAH20228.1 285 DCI protein [Homo sapiens]
GI:295842266 GenBank EAW85525.1 285 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase), isoform CRA_c [Homo sapiens]
GI:62530384 GenBank AEQ84557.1 302 Sequence 50 from patent US 8039587
GI:62530384 GenBank AEU53420.1 302 Sequence 50 from patent US 8062891
GI:62530384 GenBank AGO72373.1 302 Sequence 50 from patent US 8470972
GI:62530384 GenBank AGU32364.1 302 Sequence 50 from patent US 8507277
GI:62530384 GenBank AGX48268.1 302 Sequence 50 from patent US 8541550

Related Sequences to LMP002674 proteins

Reference Database Accession Length Protein Name
GI:295842266 DBBJ BAF83816.1 302 unnamed protein product [Homo sapiens]
GI:62530384 EMBL CAA81065.1 302 dodecenoyl-CoA delta-isomerase [Homo sapiens]
GI:295842266 EMBL CAA81066.1 302 dodecenoyl-CoA delta-isomerase [Homo sapiens]
GI:62530384 GenBank AAH00762.1 302 Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) [Homo sapiens]
GI:62530384 GenBank AAH19316.1 302 Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) [Homo sapiens]
GI:295842266 GenBank EAW85524.1 302 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase), isoform CRA_b [Homo sapiens]
GI:62530384 GenBank ACM85302.1 304 Sequence 10800 from patent US 6812339
GI:295842266 GenBank AGO72373.1 302 Sequence 50 from patent US 8470972
GI:62530384 GenBank AIC62486.1 302 ECI1 [synthetic construct]
GI:295842266 RefSeq NP_001910.2 302 enoyl-CoA delta isomerase 1, mitochondrial isoform 1 precursor [Homo sapiens]
GI:62530384 RefSeq XP_007980784.1 302 PREDICTED: enoyl-CoA delta isomerase 1, mitochondrial [Chlorocebus sabaeus]
GI:295842266 SwissProt P42126.1 302 RecName: Full=Enoyl-CoA delta isomerase 1, mitochondrial; AltName: Full=3,2-trans-enoyl-CoA isomerase; AltName: Full=Delta(3),Delta(2)-enoyl-CoA isomerase; Short=D3,D2-enoyl-CoA isomerase; AltName: Full=Dodecenoyl-CoA isomerase; Flags: Precursor [Homo sapiens]