Gene/Proteome Database (LMPD)

LMPD ID
LMP002677
Gene ID
84647
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group XIIB
Gene Symbol
PLA2G12B
Synonyms
GXIIB; GXIIIsPLA2; PLA2G13
Alternate Names
group XIIB secretory phospholipase A2-like protein; sPLA2-GXIIB; phospholipase A2, group XIII; group XIII secreted phospholipase A2; group XIII secretory phospholipase A2-like protein
Chromosome
10
Map Location
10q22.1
Summary
Phospholipase A2 (PLA2) enzymes catalyze hydrolysis of glycolipids to release free fatty acids and lysophospholipids. PLA2G12B belongs to the PLA2 family, but it is catalytically inactive due to an amino acid change in its active site and has altered phospholipid-binding properties (Rouault et al., 2003 [PubMed 14516201]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for PLA2G12B

Proteins

group XIIB secretory phospholipase A2-like protein precursor
Refseq ID NP_115951
Protein GI 45505135
UniProt ID Q9BX93
mRNA ID NM_032562
Length 195
RefSeq Status VALIDATED
MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1933 peptide sequence: MKLASGFLVLWLSLGGGLA mat_peptide: 20..195 product: Group XIIB secretory phospholipase A2-like protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BX93.2) calculated_mol_wt: 19744 peptide sequence: QSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL

Gene Information

Entrez Gene ID
84647
Gene Name
phospholipase A2, group XIIB
Gene Symbol
PLA2G12B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 IEA:InterPro F phospholipase A2 activity
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0016042 IEA:InterPro P lipid catabolic process
GO:0070328 IEA:Ensembl P triglyceride homeostasis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion
hsa04014 Ras signaling pathway
hsa04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR016090 Phospholipase A2 domain
IPR010711 Phospholipase A2, group XII secretory

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group XIIB
Protein Entry
PG12B_HUMAN
UniProt ID
Q9BX93
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BX93-1; Sequence=Displayed; Name=2; IsoId=Q9BX93-2; Sequence=VSP_054398;
Cofactor Name=Ca(2+); Xref=ChEBI
Function Not known; does not seem to have catalytic activity.
Similarity Belongs to the phospholipase A2 family.
Subcellular Location Secreted.
Tissue Specificity Strong expression in liver, small intestine and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002677 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45505135 RefSeq NP_115951 195 group XIIB secretory phospholipase A2-like protein precursor

Identical Sequences to LMP002677 proteins

Reference Database Accession Length Protein Name
GI:45505135 GenBank AEU43340.1 195 Sequence 89 from patent US 8052970
GI:45505135 GenBank AEU43468.1 195 Sequence 217 from patent US 8052970
GI:45505135 GenBank AEU43510.1 195 Sequence 259 from patent US 8052970
GI:45505135 GenBank AGF22446.1 195 Sequence 12 from patent US 8372594
GI:45505135 GenBank AHE02293.1 195 Sequence 60647 from patent US 8586006
GI:45505135 GenBank AIC52593.1 195 PLA2G12B, partial [synthetic construct]

Related Sequences to LMP002677 proteins

Reference Database Accession Length Protein Name
GI:45505135 GenBank AEJ71327.1 194 Sequence 1111 from patent US 7968689
GI:45505135 RefSeq XP_003271283.1 195 PREDICTED: group XIIB secretory phospholipase A2-like protein [Nomascus leucogenys]
GI:45505135 RefSeq XP_003816028.1 195 PREDICTED: group XIIB secretory phospholipase A2-like protein isoform X1 [Pan paniscus]
GI:45505135 RefSeq XP_004049630.1 195 PREDICTED: group XIIB secretory phospholipase A2-like protein [Gorilla gorilla gorilla]
GI:45505135 RefSeq XP_007961282.1 195 PREDICTED: group XIIB secretory phospholipase A2-like protein isoform X1 [Chlorocebus sabaeus]
GI:45505135 RefSeq XP_009456957.1 194 PREDICTED: group XIIB secretory phospholipase A2-like protein isoform X2 [Pan troglodytes]