Gene/Proteome Database (LMPD)

LMPD ID
LMP002688
Gene ID
12908
Species
Mus musculus (Mouse)
Gene Name
carnitine acetyltransferase
Gene Symbol
Crat
Synonyms
AW107812; CARAT
Alternate Names
carnitine O-acetyltransferase; CAT; carnitine acetylase
Chromosome
2
Map Location
2 B|2 21.69 cM
EC Number
2.3.1.7

Proteins

carnitine O-acetyltransferase
Refseq ID NP_031786
Protein GI 85662408
UniProt ID P47934
mRNA ID NM_007760
Length 626
RefSeq Status VALIDATED
MLAFAARTVVKPLGLLKPSSLMKVSGRFKAHQDALPRLPVPPLQQSLDYYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKKMENWLSEWWLKTAYLQFRQPVVIYSSPGVILPKQDFVDLQGQLRFAAKLIEGVLDFKSMIDNETLPVEFLGGQPLCMNQYYQILSSCRVPGPKQDSVVNFLKSKRPPTHITVVHNYQFFELDVYHSDGTPLTSDQIFVQLEKIWNSSLQSNKEPVGILTSNHRNTWAKAYNNLIKDKVNRESVNSIQKSIFTVCLDKQVPRVSDDVYRNHVAGQMLHGGGSKFNSGNRWFDKTLQFIVAEDGSCGMVYEHAAAEGPPIVALVDHVMEYTKKPELVRSPMVPLPMPKKLRFNITPEIKNDIEKAKQNLSIMIQDLDIMMLTFHHFGKDFPKSEKLSPDAFIQVALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASIDSLAFVKGMGDSTVPEQQKVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGICYNPMEAHINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQNHPRAKL

Gene Information

Entrez Gene ID
12908
Gene Name
carnitine acetyltransferase
Gene Symbol
Crat
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0004092 IEA:UniProtKB-EC F carnitine O-acetyltransferase activity
GO:0019254 IEA:Ensembl P carnitine metabolic process, CoA-linked
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0006810 IEA:UniProtKB-KW P transport

KEGG Pathway Links

KEGG Pathway ID Description
mmu04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5893692 Beta-oxidation of pristanoyl-CoA
5893699 Beta-oxidation of very long chain fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine acetyltransferase
Protein Entry
CACP_MOUSE
UniProt ID
P47934
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + carnitine = CoA + O- acetylcarnitine.
Function Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Similarity Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Subunit Monomer. {ECO:0000269|PubMed:12526798, ECO:0000269|PubMed:15155726}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002688 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
85662408 RefSeq NP_031786 626 carnitine O-acetyltransferase

Identical Sequences to LMP002688 proteins

Reference Database Accession Length Protein Name
GI:85662408 DBBJ BAE21016.1 626 unnamed protein product [Mus musculus]
GI:85662408 GenBank AAH06668.1 626 Carnitine acetyltransferase [Mus musculus]
GI:85662408 SwissProt P47934.3 626 RecName: Full=Carnitine O-acetyltransferase; Short=Carnitine acetylase; AltName: Full=Carnitine acetyltransferase; Short=CAT; Short=CrAT [Mus musculus]

Related Sequences to LMP002688 proteins

Reference Database Accession Length Protein Name
GI:85662408 DBBJ BAE41993.1 626 unnamed protein product [Mus musculus]
GI:85662408 EMBL CAA59971.1 627 carnitine acetyltransferase [Mus musculus]
GI:85662408 RefSeq NP_001004085.1 626 carnitine O-acetyltransferase [Rattus norvegicus]
GI:85662408 RefSeq XP_006497708.1 631 PREDICTED: carnitine O-acetyltransferase isoform X1 [Mus musculus]
GI:85662408 RefSeq XP_006497709.1 631 PREDICTED: carnitine O-acetyltransferase isoform X2 [Mus musculus]
GI:85662408 SwissProt Q704S8.1 626 RecName: Full=Carnitine O-acetyltransferase; Short=Carnitine acetylase; AltName: Full=Carnitine acetyltransferase; Short=CAT; Short=CrAT [Rattus norvegicus]