Gene/Proteome Database (LMPD)

LMPD ID
LMP002700
Gene ID
5729
Species
Homo sapiens (Human)
Gene Name
prostaglandin D2 receptor (DP)
Gene Symbol
PTGDR
Synonyms
AS1; ASRT1; DP; DP1; PTGDR1
Chromosome
14
Map Location
14q22.1
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Orthologs
View orthologs and multiple alignments for PTGDR

Proteins

prostaglandin D2 receptor isoform 1
Refseq ID NP_000944
Protein GI 28466969
UniProt ID Q13258
mRNA ID NM_000953
Length 359
RefSeq Status REVIEWED
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
prostaglandin D2 receptor isoform 2
Refseq ID NP_001268398
Protein GI 28466969
UniProt ID Q13258
mRNA ID NM_001281469
Length 359
RefSeq Status REVIEWED
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL

Gene Information

Entrez Gene ID
5729
Gene Name
prostaglandin D2 receptor (DP)
Gene Symbol
PTGDR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0005886 IDA:BHF-UCL C plasma membrane
GO:0004956 NAS:UniProtKB F prostaglandin D receptor activity
GO:0001785 IEA:Ensembl F prostaglandin J receptor activity
GO:0007186 NAS:UniProtKB P G-protein coupled receptor signaling pathway
GO:0046085 IEA:Ensembl P adenosine metabolic process
GO:0071799 IEA:Ensembl P cellular response to prostaglandin D stimulus
GO:0006954 IEA:Ensembl P inflammatory response
GO:0030238 IEA:Ensembl P male sex determination
GO:0030431 IEA:Ensembl P sleep

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19327 G alpha (s) signalling events
REACT_18425 Prostanoid ligand receptors

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000376 Prostaglandin D receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin D2 receptor (DP)
Protein Entry
Q13258_HUMAN
UniProt ID
Q13258
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13258-1; Sequence=Displayed; Name=2; IsoId=Q13258-2; Sequence=VSP_055141, VSP_055142; Note=No experimental confirmation available. Derived from EST data.;
Disease Asthma-related traits 1 (ASRT1) [MIM
Function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane ; Multi-pass membrane protein .
Tissue Specificity Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. {ECO
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/apobec3f/";

Identical and Related Proteins

Unique RefSeq proteins for LMP002700 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28466969 RefSeq NP_000944 359 prostaglandin D2 receptor isoform 1
28466969 RefSeq NP_001268398 359 prostaglandin D2 receptor isoform 2

Identical Sequences to LMP002700 proteins

Reference Database Accession Length Protein Name
GI:28466969 DBBJ BAG74184.1 359 prostaglandin D2 receptor, partial [synthetic construct]
GI:28466969 DBBJ BAG74184.1 359 prostaglandin D2 receptor, partial [synthetic construct]
GI:28466969 GenBank ACN08919.1 359 Sequence 15 from patent US 7488799
GI:28466969 GenBank ACN08919.1 359 Sequence 15 from patent US 7488799
GI:28466969 GenBank ADL99485.1 359 Sequence 15 from patent US 7723074
GI:28466969 GenBank ADL99485.1 359 Sequence 15 from patent US 7723074
GI:28466969 GenBank AFL01479.1 359 Sequence 4 from patent US 8165517
GI:28466969 GenBank AFL01479.1 359 Sequence 4 from patent US 8165517
GI:28466969 GenBank AIC49524.1 359 PTGDR, partial [synthetic construct]
GI:28466969 GenBank AIC49524.1 359 PTGDR, partial [synthetic construct]
GI:28466969 RefSeq XP_005267948.1 359 PREDICTED: prostaglandin D2 receptor isoform X1 [Homo sapiens]
GI:28466969 RefSeq XP_005267948.1 359 PREDICTED: prostaglandin D2 receptor isoform X1 [Homo sapiens]

Related Sequences to LMP002700 proteins

Reference Database Accession Length Protein Name
GI:28466969 PRF - 359 prostanoid DP receptor [Homo sapiens]
GI:28466969 PRF - 359 prostanoid DP receptor [Homo sapiens]
GI:28466969 RefSeq XP_002824788.1 359 PREDICTED: prostaglandin D2 receptor isoform X1 [Pongo abelii]
GI:28466969 RefSeq XP_002824788.1 359 PREDICTED: prostaglandin D2 receptor isoform X1 [Pongo abelii]
GI:28466969 RefSeq XP_003267742.1 359 PREDICTED: prostaglandin D2 receptor [Nomascus leucogenys]
GI:28466969 RefSeq XP_003267742.1 359 PREDICTED: prostaglandin D2 receptor [Nomascus leucogenys]
GI:28466969 RefSeq XP_509948.3 351 PREDICTED: LOW QUALITY PROTEIN: prostaglandin D2 receptor [Pan troglodytes]
GI:28466969 RefSeq XP_509948.3 351 PREDICTED: LOW QUALITY PROTEIN: prostaglandin D2 receptor [Pan troglodytes]
GI:28466969 RefSeq XP_003831761.1 359 PREDICTED: prostaglandin D2 receptor isoform X1 [Pan paniscus]
GI:28466969 RefSeq XP_003831761.1 359 PREDICTED: prostaglandin D2 receptor isoform X1 [Pan paniscus]
GI:28466969 RefSeq XP_004055222.1 359 PREDICTED: prostaglandin D2 receptor [Gorilla gorilla gorilla]
GI:28466969 RefSeq XP_004055222.1 359 PREDICTED: prostaglandin D2 receptor [Gorilla gorilla gorilla]