Gene/Proteome Database (LMPD)

LMPD ID
LMP002702
Gene ID
11313
Species
Homo sapiens (Human)
Gene Name
lysophospholipase II
Gene Symbol
LYPLA2
Synonyms
APT-2; DJ886K2.4
Alternate Names
acyl-protein thioesterase 2; LPL-II; lysoPLA II
Chromosome
1
Map Location
1p36.11
EC Number
3.1.2.-
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for LYPLA2

Proteins

acyl-protein thioesterase 2
Refseq ID NP_009191
Protein GI 9966764
UniProt ID O95372
mRNA ID NM_007260
Length 231
RefSeq Status REVIEWED
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

Gene Information

Entrez Gene ID
11313
Gene Name
lysophospholipase II
Gene Symbol
LYPLA2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003140 Phospholipase/carboxylesterase/thioesterase

UniProt Annotations

Entry Information

Gene Name
lysophospholipase II
Protein Entry
LYPA2_HUMAN
UniProt ID
O95372
Species
Human

Comments

Comment Type Description
Catalytic Activity Palmitoyl-protein + H(2)O = palmitate + protein.
Function May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.
Sequence Caution Sequence=AAP97210.1; Type=Frameshift; Positions=5, 164, 179; Evidence= ;
Similarity Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP002702 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9966764 RefSeq NP_009191 231 acyl-protein thioesterase 2

Identical Sequences to LMP002702 proteins

Reference Database Accession Length Protein Name
GI:9966764 RefSeq XP_007978260.1 231 PREDICTED: acyl-protein thioesterase 2 [Chlorocebus sabaeus]
GI:9966764 RefSeq XP_008263910.1 231 PREDICTED: acyl-protein thioesterase 2 [Oryctolagus cuniculus]
GI:9966764 RefSeq XP_008692835.1 231 PREDICTED: acyl-protein thioesterase 2 [Ursus maritimus]
GI:9966764 RefSeq XP_008961367.1 231 PREDICTED: acyl-protein thioesterase 2 isoform X2 [Pan paniscus]
GI:9966764 RefSeq XP_009448865.1 231 PREDICTED: acyl-protein thioesterase 2 isoform X1 [Pan troglodytes]
GI:9966764 RefSeq XP_010354065.1 231 PREDICTED: acyl-protein thioesterase 2 [Rhinopithecus roxellana]

Related Sequences to LMP002702 proteins

Reference Database Accession Length Protein Name
GI:9966764 RefSeq XP_004465472.1 342 PREDICTED: acyl-protein thioesterase 2 isoform 1 [Dasypus novemcinctus]
GI:9966764 RefSeq XP_004465473.1 342 PREDICTED: acyl-protein thioesterase 2 isoform 2 [Dasypus novemcinctus]
GI:9966764 RefSeq XP_004465474.1 314 PREDICTED: acyl-protein thioesterase 2 isoform 3 [Dasypus novemcinctus]
GI:9966764 RefSeq XP_004465475.1 281 PREDICTED: acyl-protein thioesterase 2 isoform 4 [Dasypus novemcinctus]
GI:9966764 RefSeq XP_004783519.1 307 PREDICTED: acyl-protein thioesterase 2 isoform X5 [Mustela putorius furo]
GI:9966764 RefSeq XP_001501400.3 281 PREDICTED: acyl-protein thioesterase 2 isoform X1 [Equus caballus]