Gene/Proteome Database (LMPD)

LMPD ID
LMP002711
Gene ID
74309
Species
Mus musculus (Mouse)
Gene Name
oxysterol binding protein 2
Gene Symbol
Osbp2
Synonyms
1700095P05Rik; C630001G20Rik; Gm244; ORP-4; OSBPL1
Alternate Names
oxysterol-binding protein 2
Chromosome
11
Map Location
11 A1|11
Summary
The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Orthologs
View orthologs and multiple alignments for Osbp2

Proteins

oxysterol-binding protein 2 isoform 1
Refseq ID NP_690031
Protein GI 61744458
UniProt ID Q5QNQ6
mRNA ID NM_152818
Length 908
RefSeq Status REVIEWED
MGKAAALSRGGGCAGRSRGLSSLFTVVPCLSCHTAAPGMNSSAFGSGPASKPQLQPVQAPERELLSKQVCQPISEPASRSEPGSQTTSVPRPSGVGQESELQGLWPGSENGTRSVSIIKASPELAMPSPLQSTVGSLPVTKPESKLVPKTQSFLRQGQAKISVGTPVSGIGVQMVSPPLDSYKGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRATINLASTHFETEDSCGILLCNGARTYHLKASSEVDRQHWITALELAKAKAIRVMKTQSDDSGDDDEEPAAPADNSELHHTLKTLSLKLNDLSTCNDLIAKHGAALQRSLNELDSLKIPSECGEKLKVVNERATLFRITSNAMINACRDFLELAETHSRKWQRALNYEQEQRVHLEETIEQLAKQHNSLERAFCNTPGGPASSSKSFSEGSFLTSKGENSEEDEDTEYFDAMEDSTSFITVVTEAKEDRKPESGPGTTTVDWTSADNVLDGASFMPKNSCKVKRRVRIPDKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRMEDMGLRSLCEQVSHHPPSAAHHVFSKHGWSLWQEITIASKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTKDRCQLKFVPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDDQMECSKIVHSSPSSDGRQKTVYQTLPAKLLWRKYPLPENAENMYYFSELALTLNEQEDGVAPTDSRLRPDQRLMERGRWDEANTEKQRLEEKQRLSRRRRLESCTAGCGGEEEKESDGYVPLWFEKRLDPLTGEMACMYKGGYWEAKEKKDWHMCPNIF

Gene Information

Entrez Gene ID
74309
Gene Name
oxysterol binding protein 2
Gene Symbol
Osbp2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein 2
Protein Entry
OSBP2_MOUSE
UniProt ID
Q5QNQ6
Species
Mouse

Comments

Comment Type Description
Function Binds 7-ketocholesterol. {ECO:0000250}.
Similarity Belongs to the OSBP family. {ECO:0000305}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002711 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
61744458 RefSeq NP_690031 908 oxysterol-binding protein 2 isoform 1

Identical Sequences to LMP002711 proteins

Reference Database Accession Length Protein Name
GI:61744458 SwissProt Q5QNQ6.1 908 RecName: Full=Oxysterol-binding protein 2 [Mus musculus]

Related Sequences to LMP002711 proteins

Reference Database Accession Length Protein Name
GI:61744458 GenBank EDL40442.1 908 oxysterol binding protein 2 [Mus musculus]
GI:61744458 GenBank EDM00193.1 896 oxysterol binding protein 2 (predicted) [Rattus norvegicus]
GI:61744458 RefSeq NP_001100702.1 896 oxysterol-binding protein 2 [Rattus norvegicus]
GI:61744458 RefSeq XP_006514912.1 912 PREDICTED: oxysterol-binding protein 2 isoform X1 [Mus musculus]
GI:61744458 RefSeq XP_006514913.1 911 PREDICTED: oxysterol-binding protein 2 isoform X2 [Mus musculus]
GI:61744458 RefSeq XP_006514914.1 909 PREDICTED: oxysterol-binding protein 2 isoform X3 [Mus musculus]